Neuroleptic Malignant Syndrome Due to Risperidone Overdose in a Child: A Case Report

Saltık, Sema; Başgül, Şaziye Senem

doi:10.5455/bcp.20111212084626

Cited by 3 publications

(2 citation statements)

References 26 publications

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“…The results showed that increased CPK level in all cases of severe and fatal toxicity grades and in (12 %) of cases of moderate grade. This is in agreement with Saltik and Basgul, (2012) who reported that numerous cases of Neuro Malignant Syndrome (NMS) have been reported with atypical antipsychotic medications including clozapine, olanzapine, quetiapine, and risperidone in recent years. On contrary to Strawn et al, (2007) ; Seitz and Gill, (2009) reported that NMS most often associated with typical high-potency neuroleptics e.g.…”

Section: Discussionsupporting

confidence: 93%

A Prospective Study of Poisoning Severity Score among Acute Antipsychotic Poisoned Cases Admitted to Menoufia Poison Control Center (MPCC) Throughout One Year

Hammad

Girgis

Amin

et al. 2015

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Antipsychotics rank in the top five substance classes involved in human exposures. Overdose of antipsychotic medications is common. Aim of the work: to study antipsychotic drug poisoning cases that were admitted to MPCC during one year as regarding: socio demographic pattern, their clinical manifestation, investigation and outcome according to poisoning severity score (PSS). Patients and Method: Patients complaining of antipsychotic drug overdose admitted to MPCC from 1 st October 2012 to 30 th September 2013 were included. The socio-demographic and clinical data were collected from each patient in a designed clinical toxicological sheet. The studied cases were classified according to poisoning severity score. Results: The total patient's number was 60 patients. Females outnumbered males. Cases 33.3% below 10 years old were males, while females above 40 years old constituted 50.2%. Accidental poisoning was in males below age of 10 years from rural side, on the other hand 75% of females exposed to suicidal mode mainly from urban area. Regarding (PSS); most of cases were of moderate degree and the least were of severe and fatal degrees. Palpitation and abnormal movements were the commonest symptoms. Sinus tachycardia was the most prominent ECG changes seen in 20% of cases. ICU admission was indicated for 16.7% of cases. Improvement has occurred in 40% of cases, while only one case died. Conclusion and Recommendation: Significant relation was found between PSS and poison history as regard Co-ingestion and patients on antipsychotic therapy. Cases with moderate severity toxicity had palpation and abnormal movements. Acute antipsychotic overdose seldom results in death. Therefore it is recommended to improve awareness of physician about appropriate pharmacologic treatment of psychiatric problems.

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Section: Discussionsupporting

confidence: 93%

A Prospective Study of Poisoning Severity Score among Acute Antipsychotic Poisoned Cases Admitted to Menoufia Poison Control Center (MPCC) Throughout One Year

Hammad

Girgis

Amin

et al. 2015

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…Concurrently with proteolysis, other processes occur such as fibrinolysis and coagulation. [ 13 ] The latter is associated with nonspecific resistance of the body.…”

Section: Introductionmentioning

confidence: 99%

Retracted: The systemic inflammatory response syndrome in acute antipsychotic poisoning

Zhang

Qiu

Orlova

2020

J Biochem & Molecular Tox

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The purpose of this study was to investigate the mutual effect of systemic inflammatory response syndrome (SIRS) accompanied with fibrinolysis, endotoxemia, and coagulation in severe cases of antipsychotic poisoning. A total of 199 patients were examined, of which 71 were men and 128 were women. The age of the patients was from 22 to 63 years, (45.3 ± 6.1 years on average). According to the results of the course of therapy, the patients were divided into two groups. In the blood plasma, the content of C-reactive protein, fibrinogen and its proteolysis products (oligopeptides, D-dimers), interleukin-6 were determined. In the first 1 to 3 days, in group 1, the level of interleukin-6 decreased and approached the normal level (P ≤ .05). The opposite trend continued throughout the observation of patients from group 2-their levels of interleukin-6 increased day by day (P ≤ .05). The concentration of D-dimer already in 1 day after admission to intensive care in patients from group 2 exceeded the norm by 14 times (P ≤ .05). The level of D-dimer correlated with the level of oligopeptides in blood plasma upon admission, as well as for

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Antipsychotic Drugs

Chue¹,

Neagu²

2014

Side Effects of Drugs Annual

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Neuroleptic Malignant Syndrome Due to Risperidone Overdose in a Child: A Case Report

Cited by 3 publications

References 26 publications

A Prospective Study of Poisoning Severity Score among Acute Antipsychotic Poisoned Cases Admitted to Menoufia Poison Control Center (MPCC) Throughout One Year

A Prospective Study of Poisoning Severity Score among Acute Antipsychotic Poisoned Cases Admitted to Menoufia Poison Control Center (MPCC) Throughout One Year

Retracted: The systemic inflammatory response syndrome in acute antipsychotic poisoning

Antipsychotic Drugs

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