“…A number of factors are believed to increase the risk of NMS, including abrupt starting or dose escalation, depot formulations, male gender, young age, concomitant use of lithium and selective serotonine reuptake inhibitors (SSRIs), high ambient temperatures, hyponatremia, dehydration, physical exhaustion, mental retardation, extrapyramidal syndromes, psychomotor agitation and a previous episode of NMS 24 . NMS occurs in all age groups, from 9 months to 78 years, with mean ages around the fourth and fifth decades across studies [20][21][22][23][24] . Mortality remains relatively high, varying from 20 to 30% of cases [20][21][22] .…”