Neuroleptic drug effects on cognitive function in schizophrenia

Cleghorn, J.M.; Kaplan, R.D.; Szetchman, B.; Szetchman, H.; Brown, G.M.

doi:10.1016/0920-9964(90)90155-z

Cited by 16 publications

(17 citation statements)

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“…For iloperidone no clinical data on cognitive functions are presently available. Several clinical studies suggest that atypical drugs elicit distinct cognitive effects (Cleghorn et al 1990;Cutmore and Beninger 1990). Thus, cognitive improvements afforded by iloperidone might further broaden the spectrum of activity available to clinicians in the treatment of schizophrenia.…”

Section: Discussionmentioning

confidence: 98%

Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm

2003

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Section: Discussionmentioning

confidence: 98%

Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm

2003

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“…Conventional antipsychotic treatments (eg haloperidol) are reported to lack effect on cognitive deficits (Mortimer, 1997), and to impair some cognitive functions (Cleghorn et al, 1990;Cutmore and Beninger, 1990). Novel antipsychotic compounds (second-generation or 'atypical' antipsychotics) such as clozapine (Fitton and Heel, 1990), olanzapine (Fulton and Goa, 1997), and sertindole (Kane and Tamminga, 1997;Azorin et al, 2006) have some beneficial effect on negative symptoms and reduced potential to produce extrapyramidal side effects, but these agents have demonstrated inconsistent effects on cognitive function in patients with schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Reversal of Subchronic PCP-Induced Deficits in Attentional Set Shifting in Rats by Sertindole and a 5-HT6 Receptor Antagonist: Comparison Among Antipsychotics

Rodefer

Nguyen

Karlsson

et al. 2007

Neuropsychopharmacol

114

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Currently accepted treatments for schizophrenia can effectively control positive symptoms but have limited impact on cognitive deficits in schizophrenia. The purpose of these experiments was to address this unmet need by characterizing the effects of classical and secondgeneration antipsychotics on cognitive impairments associated with schizophrenia. An additional aim was to characterize the part(s) of the pharmacological profile of drugs that were important to reverse deficits. Cognitive deficits were assessed using a frontally mediated attentional set-shifting task in rats that is analogous to tasks used in humans and nonhuman primates that assess executive function. Mirroring findings in patients with schizophrenia, the classical antipsychotic haloperidol was ineffective in treating set-shifting deficits induced by subchronic treatment with phencyclidine (PCP). Similarly, second-generation antipsychotics, risperidone, clozapine, and olanzapine were ineffective. In contrast, selected doses of sertindole and the 5-HT 6 receptor antagonist SB 271046 attenuated PCPinduced set-shifting deficits. Finally, the 5-HT 2A receptor antagonist M100907 was without effect. Further examination revealed that repeated treatment (21 days) with sertindole, but not olanzapine, also was effective in reversing the executive function deficit. These data suggest that the combination of 5-HT 6 antagonistic activity and the absence of antimuscarinic activity may represent key characteristics of the pharmacological profile for improved antipsychotic drugs for schizophrenia.

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“…Patients were on neuroleptic and anticholinergic medication (benzotropine). Neuroleptic medication is usually found not to affect such memory tasks appreciably [11,14,[20][21][22][23][24][25][26][27][28][29], while anticholinergic medication is sometimes reported to affect them [30,31]. The group of patients with no positive symptoms ever reported tended to have lower levels of these medications, as could be expected.…”

Section: Methodsmentioning

confidence: 59%

“…Some reports, however, showed only a trend [14]. It seems that the nonsignificant findings of rapid forgetting that sometimes emerge may be an artifact of task differences in discriminating power.…”

Section: Introductionmentioning

confidence: 84%

See 1 more Smart Citation

Immediate and Delayed Memory Performance in Schizophrenia Spectrum Patients: Use of Matched Tasks

Calev

2001

Psychopathology

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Rapid forgetting has been observed in long-term schizophrenic patients in the past. In this study, the rate of forgetting was assessed in short-term schizophrenic, schizophreniform and schizoaffective patients who had positive symptoms in the past, and in schizophreniform patients who never had positive symptoms. Four groups of patients representing these distinctions and a group of normal controls were assessed using immediate and delayed recall tasks, while controlling for effects of discriminating power of tasks, using matched-task methodology. The results showed that all schizophrenia spectrum patients with positive symptoms showed rapid forgetting as compared to schizophreniform patients with negative symptoms and normal controls. It is concluded that better immediate than delayed recall characterizes schizophrenia spectrum patients who have had positive symptoms. However, schizophrenia spectrum patients with negative symptoms may be qualitatively different from patients with positive symptoms in showing a slower rate of forgetting. The results support the hypothesis that there is at least one and possibly two brain dysfunctions affecting memory in schizophrenia.

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Neuroleptic drug effects on cognitive function in schizophrenia

Cited by 16 publications

References 0 publications

Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm

Differential effects of iloperidone, clozapine, and haloperidol on working memory of rats in the delayed non-matching-to-position paradigm

Reversal of Subchronic PCP-Induced Deficits in Attentional Set Shifting in Rats by Sertindole and a 5-HT6 Receptor Antagonist: Comparison Among Antipsychotics

Immediate and Delayed Memory Performance in Schizophrenia Spectrum Patients: Use of Matched Tasks

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