Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women

Noninvasive in vivo monitoring of tissue-specific global gene expression in humans

“…Other transcripts in our placental assay are known to be transcribed at high levels in the placenta, and levels of these mRNAs are important for normal placental function and development in pregnancy. TAC3 is mainly expressed in the placenta and is significantly elevated in preeclamptic human placentas at term (39,40). Similarly, PLAC1 is essential for normal placental development.…”

Soluble Fms-like Tyrosine Kinase 1 and Endothelial Dysfunction in the Pathogenesis of Preeclampsia

“…Page and colleagues (71) found that levels of neurokinin-B (NK-B), a neurotransmitter apparently produced by the placenta, were elevated in women with preeclampsia, and that rats infused with high doses of NK-B developed transient hypertension. However, their findings have not borne out in subsequent studies (72,73). There is also recent data that increased syncytiotrophoblast shedding in preeclampsia as a consequence of placental apoptosis may contribute to endothelial dysfunction in cell culture studies.…”

Third trimester plasma neurokinin B levels in women with and without preeclampsia

“…In contrast, Schlembach et al [20], reported low NKB values in 14 pregnant women with PE compared to eight healthy pregnant women with relatively increased values. D'Anna et al [21] found a correlation between elevated levels of NKB and …”

“…In contrast to others [7,20,21], our study presents NKB data from a larger study group (N ¼ 166) using C18 solid phase extraction of the sample, lyophilization of the eluates, and NKB determination by a commercially available EIA. As previously confirmed [11] for NKB, the EIA is as reliable as radioimmunoassay (RIA) -the current gold standard.…”