Neurokinin 3 Receptor Effects on Cognitive Behaviour in a Rat Model of Alzheimer's Disease

Koca, Raviye Özen; Görmüş, Zülfikare İşık Solak; Solak, Hatice; Koç, Aynur; Kılınç, İbrahim; İyisoy, Sinan; Kutlu, Selim

doi:10.21203/rs.3.rs-517911/v1

Cited by 1 publication

(1 citation statement)

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“…Moreover, the application of senktide was effective in improving cognitive functions in rats with AD pathology. The protective effects of senktide on AD rats may rely on the enhanced cholinergic system ( Koca et al, 2021 ). In contrast, knockout of NK3R in mice led to a series of cognitive deficits, as seen in the passive avoidance test, conditioned avoidance response and Morris water maze ( Siuciak et al, 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

Huang,

Ai,

Wei

et al. 2023

Protein &Amp; Cell

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Sporadic or late-onset Alzheimer’s disease (LOAD) accounts for more than 95% of AD cases without any family history. Although genome-wide association studies (GWAS) have identified associated risk genes and loci for LOAD, numerous studies suggest that many adverse environmental factors, such as social isolation, are associated with an increased risk of dementia. However, the underlying mechanisms of social isolation in AD progression remain elusive. In the current study, we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD mice. We also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 DG-enriched miRNAs, which simultaneously target reticulon 3 (RTN3), an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fiber boutons (MFBs) by recruiting multiple mitochondrial and vesicle-related proteins. Interestingly, the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation, which in turn further elevates RTN3 and forms a vicious cycle. Finally, using an artificial intelligence (AI)-assisted molecular docking approach, we determined that senktide, a selective agonist of neurokinin3 receptors (NK3R), could reduce the binding of RTN3 with its partners. Moreover, application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD mice. Taken together, our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

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Section: Discussionmentioning

confidence: 99%