2020
DOI: 10.1016/j.bjane.2020.06.015
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Neurokinin-1 receptor antagonists for postoperative nausea and vomiting: a systematic review and meta-analysis

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Cited by 7 publications
(6 citation statements)
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“…As research on NK1R has intensified, several NK1Rspecific inhibitors have been developed. To make it easier to translate our findings for clinical application, in this study, we chose Aprepitant which is the first NK1R-specific antagonist approved by FDA for the treatment of chemotherapyinduced nausea and vomiting [59]. Aprepitant can cross the blood-brain barrier and competitively bind to NK1R receptors in the brain antagonizing the effects of the natural ligand SP [60].…”
Section: Discussionmentioning
confidence: 99%
“…As research on NK1R has intensified, several NK1Rspecific inhibitors have been developed. To make it easier to translate our findings for clinical application, in this study, we chose Aprepitant which is the first NK1R-specific antagonist approved by FDA for the treatment of chemotherapyinduced nausea and vomiting [59]. Aprepitant can cross the blood-brain barrier and competitively bind to NK1R receptors in the brain antagonizing the effects of the natural ligand SP [60].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, metoclopramide being a D2 receptor acting as a central dopaminergic antagonist increases gastric emptying. Looking into the mechanisms of action of the different drugs used for the same purpose, it is seen that for the treatment of postoperative nausea and vomiting, dexamethasone was found to be superior in the control of nausea and vomiting [ 5 ]. However, the results of the statistical calculation obtained from the study weightage the theories about the efficiency of dexamethasone against vomiting and nausea [ 14 - 16 ].…”
Section: Discussionmentioning
confidence: 99%
“…Postoperative nausea and vomiting thus are the most commonly occurring after-effects of any surgical procedure and targets about 50% of the patients who have undergone craniotomy [ 3 , 4 ]. These adverse effects threaten life by dangerously elevating the arterial pressure and intracranial pressure of the patients [ 5 ]. All these contrary signs make the way for hemorrhage and ultimately for deaths.…”
Section: Introductionmentioning
confidence: 99%
“…As NVPO são respostas não somente do pós-operatório, mas de eventos anteriores a cirurgia, ou que ocorrem durante o procedimento e tem causas multifatoriais (AMIRI et al, 2020), podendo ser desencadeadas pela ativação de diversos receptores periféricos e/ou centrais e podem estar relacionados aos agentes emetogênicos, como os anestésicos inalatórios e os opióides, a técnica anestésica, uso de óxido nitroso e duração da anestesia (SCHMIDT, 2020). Há ainda fatores de risco relacionados ao paciente como ser do sexo feminino, ser não fumante e ter histórico de cinetose e/ou NVPO (MURAKAMI et al, 2020).…”
Section: Características Gerais De Náuseas E Vômitos No Pós-operatóriounclassified