Neurokinin-1 receptor activation in globus pallidus

Chen, Lei; Cui, Qiaoling; Yung, Wing‐Ho

doi:10.3389/neuro.23.002.2009

Cited by 2 publications

(1 citation statement)

References 70 publications

(92 reference statements)

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“…Glutamatergic STN input parameters were estimated from published miniature EPSC recordings (Chen et al, 2006; Hashimoto and Kita, 2008; Chen et al, 2009): rise time = 1 ms, decay time = 4 ms, E AMPA = 0 mV and g syn = 0.33 nS. For striatal inhibitory inputs, rise time = 0.8 ms, decay time = 5 ms, E GABA = -80 mV, and g syn = 0.75 nS (Sims et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

Dendritic Sodium Channels Promote Active Decorrelation and Reduce Phase Locking to Parkinsonian Input Oscillations in Model Globus Pallidus Neurons

Edgerton¹,

Jaeger²

2011

Journal of Neuroscience

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Correlated firing among populations of neurons is present throughout the brain and is often rhythmic in nature, observable as an oscillatory fluctuation in the local field potential. Although rhythmic population activity is believed to be critical for normal function in many brain areas, synchronized neural oscillations are associated with disease states in other cases. In the globus pallidus (GP in rodents, homolog of the primate GPe), pairs of neurons generally have uncorrelated firing in normal animals despite an anatomical organization suggesting that they should receive substantial common input. By contrast, correlated and rhythmic GP firing is observed in animal models of Parkinson's disease (PD). Based in part on these findings it has been proposed that an important part of basal ganglia function is active decorrelation, whereby redundant information is compressed. Mechanisms that implement active decorrelation, and changes that cause it to fail in PD, are subjects of great interest. Rat GP neurons express fast, transient voltage-dependent sodium channels (NaF channels) in their dendrites, with the expression level being highest near asymmetric synapses. We recently showed that the dendritic NaF density strongly influences the responsiveness of model GP neurons to synchronous excitatory inputs. In the present study we use rat GP neuron models to show that dendritic NaF channel expression is a potential cellular mechanism of active decorrelation. We further show that model neurons with lower dendritic NaF channel expression have a greater tendency to phase lock with oscillatory synaptic input patterns like those observed in PD.

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Section: Methodsmentioning

confidence: 99%

Dendritic Sodium Channels Promote Active Decorrelation and Reduce Phase Locking to Parkinsonian Input Oscillations in Model Globus Pallidus Neurons

Edgerton¹,

Jaeger²

2011

Journal of Neuroscience

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Substance P effects exclusively on prototypic neurons in mouse globus pallidus

et al. 2017

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Previous studies have suggested that the neurokinin-1 receptor (NK-1R) expressing neurons in the globus pallidus (GP) receive substance P (SP), presumably released by axon collaterals of striatal direct neurons. However, the effect of SP on the GP remains unclear. In this study, we identified that the SP-responsive cells comprise a highly specific cell type in the GP with regard to immunofluorescence, electrophysiology, and projection properties. Morphologically, NK-1R-immunoreactive neurons occasionally co-expressed parvalbumin (PV) and/or Lim-homeobox 6 (Lhx6), but not Forkhead box protein P2 (FoxP2), which is mainly expressed by arkypallidal neurons. Retrograde tracing experiments also showed that some of GP neurons projecting to the subthalamic nucleus (namely prototypic neurons) expressed NK-1R as well as Lhx6 and/or PV, but not FoxP2. In vitro electrophysiological study revealed that, among 48 GP neurons, the SP agonist induced inward current in 21 neurons. The response was prevented by bath application of the NK-1R antagonist. Based on the firing properties, 92 recorded GP neurons were classified into three distinct types, i.e., CL1, 2, and 3. Interestingly, all the SP-responsive neurons were found to be in CL2 and CL3 types, but not in CL1. Moreover, active and passive membrane properties of the neurons in those clusters and immunofluorescent identification suggested that CL1 and CL2/3 could be considered as arkypallidal and prototypic neurons, respectively. Therefore, SP-responsive neurons were one of the populations of prototypic neurons based on both anatomical and electrophysiological results. Altogether, the striatal direct pathway neurons could affect the indirect pathway in the way of prototypic neurons, via the action of SP to NK-1R.

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Neurokinin-1 receptor activation in globus pallidus

Cited by 2 publications

References 70 publications

Dendritic Sodium Channels Promote Active Decorrelation and Reduce Phase Locking to Parkinsonian Input Oscillations in Model Globus Pallidus Neurons

Dendritic Sodium Channels Promote Active Decorrelation and Reduce Phase Locking to Parkinsonian Input Oscillations in Model Globus Pallidus Neurons

Substance P effects exclusively on prototypic neurons in mouse globus pallidus

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