Neuroinflammation: The Pathogenic Mechanism of Neurological Disorders

Gorji, Ali

doi:10.3390/ijms23105744

Cited by 23 publications

(13 citation statements)

References 40 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We next quantified microglia/macrophages in the context of brain vasculature by imaging embryos derived from breeding CNS/Il-1β to the Tg(mpeg1:mCherry) gl 23 (herein mpeg1:mCherry ) and Tg(kdrl:EGFP) s8 43 (herein kdrl:EGFP ) transgenic lines. 57, 58 Since the zebrafish mpeg1 promoter drives expression in both microglia and macrophages, these specific cell types could not be distinguished for these experiments.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

Fetsko,

Sebo,

Budzynski

et al. 2023

Preprint

View full text Add to dashboard Cite

SummaryDuring neuroinflammation, the proinflammatory cytokine Interleukin-1β (IL-1β) impacts blood-brain barrier (BBB) function by disrupting brain endothelial tight junctions, promoting vascular permeability, and increasing transmigration of immune cells. Here, we examined the effects of Il-1β on thein vivodevelopment of the BBB. We generated a doxycycline-inducible transgenic zebrafish model that drives secretion of Il-1β in the CNS. To validate the utility of our model, we showed Il-1β dose-dependent mortality, recruitment of neutrophils, and expansion of microglia. Using live imaging, we discovered that Il-1β causes a significant reduction in CNS angiogenesis and barriergenesis. To demonstrate specificity, we rescued the Il-1β induced phenotypes by targeting the zebrafishil1r1gene using CRISPR/Cas9. Mechanistically, we determined that Il-1β disrupts BBB development by decreasing Wnt/β-catenin transcriptional activation in brain endothelial cells. Given that several neurodevelopmental disorders are associated with inflammation, our findings support further investigation into the connections between proinflammatory cytokines, neuroinflammation, and neurovascular development.

show abstract

Section: Resultsmentioning

confidence: 99%

“…57, 88 Tg(mpx:EGFP) uwm1 was a gift from Dr. Anna Huttenlocher (UW-Madison). 89 Tg(mpeg1:mCherry) gl 23 was provided by Dr. Owen Tamplin (UW-Madison). 58 The line Tg(7xTCF-Xla.Sia:NLS-mCherry) ia5 was provided by Dr. Junsu Kang (UW-Madison).…”

Section: Methodsmentioning

confidence: 99%

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

Fetsko,

Sebo,

Budzynski

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…46 Thus, all together our findings indicate that the water administration of MoS 2 nanosheets activate spinal cord reactivity with, in the absence of material clearance, typical neuroinflammation exacerbating loops. 47…”

Section: Discussionmentioning

confidence: 99%

MoS₂ 2D materials induce spinal cord neuroinflammation and neurotoxicity affecting locomotor performance in zebrafish

Di Mauro,

González,

Bambini

et al. 2024

Nanoscale Horiz.

View full text Add to dashboard Cite

show abstract

“…The roles of neuroinflammation are different, normally, inflammation is a defense mechanism that initially protects the brain via clearing up pathogens, cell fragments, mis-folded proteins and other stimulus to maintain or restore the integrity of tissues ( 9 ). Nevertheless, uncontrolled neuroinflammation engenders neuronal degeneration and BBB disruption, that is marked by the secretion of pro-inflammatory cytokines, chemokines, and small-molecule messengers, which are primarily released by activated microglia and astrocytes ( 10 ).…”

Section: The Physiological and Pathological Mechanisms Of Neuroinflam...mentioning

confidence: 99%

Beneficial effects of natural flavonoids on neuroinflammation

et al. 2022

View full text Add to dashboard Cite

Neuroinflammation is the fundamental immune response against multiple factors in the central nervous system and is characterized by the production of inflammatory mediators, activated microglia and astrocytes, and the recruitment of innate and adaptive immune cells to inflammatory sites, that contributes to the pathological process of related brain diseases, such as Alzheimer’s disease, Parkinson’s disease, depression, and stroke. Flavonoids, as a species of important natural compounds, have been widely revealed to alleviate neuroinflammation by inhibiting the production of pro-inflammatory mediators, elevating the secretion of anti-inflammatory factors, and modulating the polarization of microglia and astrocyte, mainly via suppressing the activation of NLRP3 inflammasome, as well as NF-κB, MAPK, and JAK/STAT pathways, promoting Nrf2, AMPK, BDNF/CREB, Wnt/β-Catenin, PI3k/Akt signals and SIRT1-mediated HMGB1 deacetylation. This review will provide the latest and comprehensive knowledge on the therapeutic benefits and mechanisms of natural flavonoids in neuroinflammation, and the natural flavonoids might be developed into food supplements or lead compounds for neuroinflammation-associated brain disorders.

show abstract

Neuroinflammation: The Pathogenic Mechanism of Neurological Disorders

Abstract: Neuroinflammation is implicated in the pathophysiology of several neurological diseases. The key role of neuroinflammation in a wide range of neurological disorders makes it highly attractive for diagnostic examinations and therapeutic interventions in recent years [...]

Cited by 23 publications

References 40 publications

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

MoS₂ 2D materials induce spinal cord neuroinflammation and neurotoxicity affecting locomotor performance in zebrafish

Beneficial effects of natural flavonoids on neuroinflammation

Contact Info

Product

Resources

About

Neuroinflammation: The Pathogenic Mechanism of Neurological Disorders

Abstract: Neuroinflammation is implicated in the pathophysiology of several neurological diseases. The key role of neuroinflammation in a wide range of neurological disorders makes it highly attractive for diagnostic examinations and therapeutic interventions in recent years [...]

Cited by 23 publications

References 40 publications

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

IL-1β disrupts blood-brain barrier development by inhibiting endothelial Wnt/β-catenin signaling

MoS2 2D materials induce spinal cord neuroinflammation and neurotoxicity affecting locomotor performance in zebrafish

Beneficial effects of natural flavonoids on neuroinflammation

Contact Info

Product

Resources

About

MoS₂ 2D materials induce spinal cord neuroinflammation and neurotoxicity affecting locomotor performance in zebrafish