Neuroinflammation in HCV-infection – Peril or protection?

Pflugrad, Henning; Ding, Xiao‐Qi; Tillmann, Hans L.; Weißenborn, Karin

doi:10.1016/j.jhep.2012.03.034

Cited by 3 publications

(2 citation statements)

References 4 publications

(9 reference statements)

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“…Taken together, there is a considerable discrepancy regarding the type and spatial extent of cerebral involvement of chronic HCV, which could be due to different sample characteristics such as history of hepatic encephalopathy, drug abuse or other viral co‐infections, diverse measurements and analysis routines and shortcomings of the techniques applied thus far …”

Section: Introductionmentioning

confidence: 99%

Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study

Masouleh

Herzig²,

Klose³

et al. 2016

Journal of Viral Hepatitis

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Chronic hepatitis C virus (HCV) infection is associated with fatigue and depression. Cognitive impairments are also reported in a smaller number of HCV-positive patients. Recent studies linked HCV to low-grade inflammation in brain. Here, we test the hypothesis that chronic HCV is associated with 3T-neuroimaging-derived grey matter volume (GMV) and functional connectivity alterations in a sample of chronic HCV (1b), without severe liver disease. Regional GMV and resting-state fMRI-derived eigenvector centrality (EC) were compared between 19 HCV-positive patients and 23 healthy controls (all females, 50-69 and 52-64 years, respectively), controlling for white matter hyperintensities and age. Standard tests were used to assess fatigue, depression and cognitive performance. Also, liver fibrosis stage and viral load were quantified among patients. In comparison with controls, HCV-positive patients had higher scores in fatigue and depression, and worse alertness scores. The groups performed similarly in other cognitive domains. We report higher EC in a cluster in the right anterior superior parietal lobule in patients, while no differences are found in GMV. Post hoc functional connectivity analysis showed increased connectivity of this cluster with primary and secondary somatosensory cortex, and temporal and occipital lobes in patients. Higher mean EC in the superior parietal cluster, adjusted for mean framewise displacement, was associated with better memory and attention performance, but not with fatigue, depression, viral load or level of liver fibrosis, among patients. These results suggest a compensatory mechanism in chronic hepatitis C and explain equivocal results in the literature about cognitive deficits in infected persons. Further studies should define the relation of these connectivity changes to the brain's inflammatory activity.

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Section: Introductionmentioning

confidence: 99%

Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study

Masouleh

Herzig²,

Klose³

et al. 2016

Journal of Viral Hepatitis

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show abstract

“…The authors also reported significant improvements in verbal learning, memory, and visuospatial memory in patients with viral clearance, although these data are not convincing. These results suggest that viral eradication may be associated with restoration of brain metabolism; however, the strength of these conclusions is limited by the small number of patients evaluated and the conclusions have been questioned [65], emphasizing the need for sufficiently powered prospective studies.…”

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confidence: 97%

Expert Opinion on Managing Chronic HCV in Patients with Neuropsychiatric Manifestations

et al. 2018

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Neurological manifestations of hepatitis C virus infection appear to be under-recognised in clinical practice despite the majority of HCV-infected patients experiencing symptoms such as fatigue, depression, and cognitive dysfunction. There is also growing evidence for a link between HCV infection and an increased risk of Parkinson's disease. The mechanism underpinning the association between HCV and these neuropsychiatric syndromes still requires further investigation. Here we review the pre-clinical and clinical evidence for a link between HCV and effects on the CNS leading to neuropsychiatric syndromes. Lastly, we describe how improvements in neuropsychiatric manifestations of HCV following treatment have been observed, which is subsequently reflected in an overall improvement in health-related quality of life.

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Evaluation of brain volume alterations in HCV-infected patients after interferon-free therapy: A pilot study

Marciniewicz

Podgórski

Pawłowski

et al. 2019

Journal of the Neurological Sciences

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Neuroinflammation in HCV-infection – Peril or protection?

Cited by 3 publications

References 4 publications

Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study

Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study

Expert Opinion on Managing Chronic HCV in Patients with Neuropsychiatric Manifestations

Evaluation of brain volume alterations in HCV-infected patients after interferon-free therapy: A pilot study

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