Neuroinflammation and Comorbidity of Pain and Depression

Walker, Adam K.; Kavelaars, Annemieke; Heijnen, Cobi J.; Dantzer, Robert

doi:10.1124/pr.113.008144

Cited by 372 publications

(332 citation statements)

References 183 publications

Supporting

Mentioning

304

Contrasting

Unclassified

Order By: Relevance

“…Although it is unclear how cytokines may initiate or influence the pathogenesis of depressive disorders, one hypothesis postulates that proinflammatory cytokines stimulate indoleamine 2,3-dioxygenase (IDO) in glial cells to convert tryptophan to kynurenine which is transformed into the neurotoxic quinolinic acid inside the brain (Müller and Schwarz, 2007;Walker et al, 2014). Quinolinic acid binds to N-methyl-D-aspartate receptors while also depleting tryptophan leading to a decrease in overall serotonin levels and an increase in glutamatergic activity commonly associated with depression (Sublette et al, 2011).…”

Section: The Inflammatory Process and Hypothesis In Mddmentioning

confidence: 99%

A review of the relationship between proinflammatory cytokines and major depressive disorder

Young

Bruno

Pomara

2014

Journal of Affective Disorders

357

228

View full text Add to dashboard Cite

Cite this article as: Juan Young, Davide Bruno, Nunzio Pomara, A review of the relationship between proinflammatory Cytokines and major depressive disorder, Journal of Affective Disorders, http://dx.doi.org/10. 1016/j.jad.2014.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Section: The Inflammatory Process and Hypothesis In Mddmentioning

confidence: 99%

A review of the relationship between proinflammatory cytokines and major depressive disorder

Young

Bruno

Pomara

2014

Journal of Affective Disorders

357

228

View full text Add to dashboard Cite

show abstract

“…Some investigators have looked for biological mechanisms that might explain the link between low mood and musculoskeletal pain, including the possible role of neurotransmitters [33] and cytokine receptors [34]. However, there is still no established neuro-chemical explanation for the association.…”

Section: Association With Musculoskeletal Illnessmentioning

confidence: 99%

“…However, recent findings from longitudinal studies suggest that among individuals who are initially free from musculoskeletal pain, those with low mood are more likely subsequently to develop pain and associated disability (Table 1). In addition, there is some evidence from experimental studies that induction of negative mood reduces pain tolerance and leads to higher levels of self-reported pain severity [32].Some investigators have looked for biological mechanisms that might explain the link between low mood and musculoskeletal pain, including the possible role of neurotransmitters [33] and cytokine receptors [34]. However, there is still no established neuro-chemical explanation for the association.…”

mentioning

confidence: 99%

Psychological and psychosocial determinants of musculoskeletal pain and associated disability

Vargas-Prada

Coggon

2015

Best Practice & Research Clinical Rheumatology

View full text Add to dashboard Cite

Although much attention has been given to the physical determinants of common musculoskeletal complaints such as back and arm pain, research points to a stronger influence of psychological factors. Multiple studies have implicated poor mental health and somatisation (a tendency to worry about common somatic symptoms) in the incidence and chronicity of musculoskeletal pain and associated disability. Also important are adverse beliefs about the prognosis of such disorders, and about the role of physical activity in their development and persistence. Differences in societal beliefs may have contributed to major variation in the prevalence of disabling musculoskeletal pain that has been observed between countries and in the same countries over time. Psychosocial aspects of work have also been linked with musculoskeletal pain, although relative risks have generally been smaller. There is a need to take account of psychological factors in the clinical management of patients with back, neck and arm pain. KeywordsMusculoskeletal pain; mental health; somatisation; health beliefs; psychosocial factors Historically, attempts to prevent incapacity for work from musculoskeletal disorders have focused mainly on the physical demands of employment. It has been assumed that symptoms and disability arise from injury to tissues, and can be prevented by better ergonomic design of occupational tasks to reduce mechanical loading. This biophysical paradigm may be appropriate for some types of musculoskeletal disease -for example, osteoarthritis of the hip caused by heavy lifting (see Chapter X) and degenerative meniscal Europe PMC Funders Group Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts tears in the knee caused by prolonged kneeling and squatting Chapter X). However, it has become increasingly apparent that the model has only limited applicability to common painful disorders of the back, neck and upper limb, which are the main musculoskeletal causes of disability for work.Most disabling pain of the back and upper limb is non-specific in nature with no clear evidence of underlying injury to tissues, and even where pathology can be demonstrated (e.g. herniation of an intervertebral disc in people with back pain), it appears often not to be the explanation for the symptom [1]. Furthermore, there have been major temporal changes in the prevalence of musculoskeletal illness and disability that cannot be explained by altered physical exposures. For example, social security statistics indicate that in Britain, long-term incapacity for work because of back pain increased more than eightfold between 1950 and the early 1990s [2], at a time when the physical demands of work were declining because of greater mechanisation and a shift in employment from manufacturing to service industries. And in Australia, there was a major epidemic of arm pain during the 1980s among office workers, which was not paralleled in other countries that were using similar technology [3].These observations indicate that factors ...

show abstract

“…Обычно этот тип воспаления не сопровождается харак-терными для острого воспаления симптомами и не ощу-щается индивидуумом. Активация глиальных клеток и нейровоспаление все чаще рассматриваются как одна из основных причин хронической боли в спине и многих сопровождающих ее синдромов, включая депрессию, усталость, бессонницу [11,12]. Активация глиальных кле-ток приводит к пролонгированному патологическому процессу в центральной нервной системе (ЦНС), который включает нейровоспаление, дисфункцию глиальных кле-ток, стимуляцию гипоталамо-гипофизарного комплекса.…”

Section: центральные механизмы формирования хронической боли в спинеunclassified

Chronic Back Pain: From Pathogenetic Concepts to Therapeutic Strategies

Vorobieva¹

2017

Med. sov.

View full text Add to dashboard Cite

Neuroinflammation and Comorbidity of Pain and Depression

Cited by 372 publications

References 183 publications

A review of the relationship between proinflammatory cytokines and major depressive disorder

A review of the relationship between proinflammatory cytokines and major depressive disorder

Psychological and psychosocial determinants of musculoskeletal pain and associated disability

Chronic Back Pain: From Pathogenetic Concepts to Therapeutic Strategies

Contact Info

Product

Resources

About