Neuroinflammation and apoptosis after surgery for a rat model of double-level cervical cord compression

Yao, Min; Gan, Li; Zhou, Long‐yun; Liu, Shufen; Li, Zhuo-Yao; Pu, Pei‐min; Sng, Kim Sia; Zheng, Zhong; Song, Yong-Jia; Zhu, Ke; Wang, Yongjun; Cui, Xue‐jun

doi:10.1016/j.neuint.2022.105340

Cited by 7 publications

(2 citation statements)

References 77 publications

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“…The missing and squeezing of gray and white matter caused a serious loss of neuronal cells in the compression area, as well as in the inflammatory zone, and neuronal tissue vacuolization (Figure 2A). According to our previous study, a large number of inflammatory cells converge in the inflammatory zone in addition to the remaining neurons and oligodendrocytes 41 . Melatonin alleviated this neuronal damage and retained some neurons that controlled cavitation.…”

Section: Resultsmentioning

confidence: 83%

“…According to our previous study, a large number of inflammatory cells converge in the inflammatory zone in addition to the remaining neurons and oligodendrocytes. 41 Melatonin alleviated this neuronal damage and retained some neurons that controlled cavitation. In addition, the inflammatory zone disappeared and ROS accumulation was restrained in the compressed area (Figure 2A-C).…”

Section: Melatonin Protected the Neurons In Rats With Chronic Compres...mentioning

confidence: 99%

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Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression

Yao

Zhu

et al. 2023

Journal of Pineal Research

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Cervical spondylotic myelopathy (CSM) refers to a chronic injury of the cervical cord caused by cervical intervertebral disc degeneration. Endoplasmic reticulum (ER) homeostasis is essential to counteract neuronal apoptosis. ER stress, an integral part of ER homeostasis, was observed in a rat model of chronic cervical cord compression in our previous study. However, the correlation between ER homeostasis and CSM remains unknown. The antioxidant melatonin is known to exert therapeutic effects in acute spinal cord injury, but the specific effects and their potential mechanisms in the pathological processes of CSM require further exploration. The present study hypothesized that ER homeostasis is essential for neuronal apoptosis in the CSM and that melatonin maintains this homeostasis. The results showed that ER stress led to neuronal apoptosis in rats with chronic cervical cord compression. Conversely, melatonin attenuates protein kinase R‐like ER kinase‐eukaryotic initiation factor 2α‐C/EBP‐homologous protein, inositol‐requiring enzyme 1, and transcription factor 6 signaling pathways to release ER stress and prevents Bax translocation to the mitochondrion, thereby promoting motor recovery and protecting neurons in vivo. It also rescued primary rat cortical neurons from ER stress‐induced glutamate toxicity in vitro. Moreover, melatonin remodels the ER morphology and restores homeostasis via ER‐phagy in injured neurons. FAM134B, CCPG1, RTN3, and Sec. 62 are four known ER‐phagy receptors. In this study, Sec. 62 was identified as a key melatonin factor in promoting ER‐phagy and restoring ER homeostasis in damaged neurons in vivo and in vitro. In conclusion, melatonin suppresses neuronal apoptosis by reducing ER stress and promoting ER‐phagy to restore ER morphology and homeostasis. The current results suggested that melatonin is a promising treatment for CSM owing to its restorative effect on ER homeostasis; however, well‐designed randomized controlled trials must be carried out to further investigate its clinical effects.

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Section: Resultsmentioning

confidence: 83%

Section: Melatonin Protected the Neurons In Rats With Chronic Compres...mentioning

confidence: 99%

Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression

Yao

Zhu

et al. 2023

Journal of Pineal Research

Self Cite

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Shenqisherong pill ameliorates neuronal apoptosis by inhibiting the JNK/caspase-3 signaling pathway in a rat model of cervical cord compression

Zhu

Gan

et al. 2024

Journal of Ethnopharmacology

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Analysis of gene expression profiles and experimental validations of a rat chronic cervical cord compression model

Dai

et al. 2023

Neurochemistry International

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Neuroinflammation and apoptosis after surgery for a rat model of double-level cervical cord compression

Cited by 7 publications

References 77 publications

Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression

Melatonin restores endoplasmic reticulum homeostasis to protect injured neurons in a rat model of chronic cervical cord compression

Shenqisherong pill ameliorates neuronal apoptosis by inhibiting the JNK/caspase-3 signaling pathway in a rat model of cervical cord compression

Analysis of gene expression profiles and experimental validations of a rat chronic cervical cord compression model

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