Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch

Background Many studies have revealed that neuroimmune is closely related to psoriasis. However, information in this field remains ambiguous. Objective Therefore, this study aimed to examine the relationship between neuroimmune and psoriasis, identify journal publications and collaborators, and analyze keywords and research trends using a bibliometric method. Methods We systematically searched the Web of Science Core Collection (WOSCC) for papers published on neuroimmune and psoriasis. Retrieved data regarding countries, institutions, authors, journals, keywords, and so on. VOSviewer, CiteSpace, R package “bibliometrix”, and MapChart were used to visualize the information through collaborative networks. Results 398 articles from 48 countries led by the United States were included. The number of publications related to neuroimmune in psoriasis showes significantly increase in recent years. University of Miami, University of California Davis and Capital Medical University are the main research institutions. The Journal of Investigative Dermatology is the most popular journal in this field. These publications come from 2028 authors, among whom Yosipovitch G, Raychaudhuri SP and Reich A had published the most papers. High-frequency keywords included “psoriasis”, “neuroinflammation “, “atopic-dermatitis”, “nerve growth-factor”, and “expression”. Recent studies have focused on “cutaneous nervous system”, “botulinum toxin”, “dementia”, and “parkinson’s disease” according to the cocitation analysis of kewords. “Botulinum toxin”, “dementia”, “Alzheimers disease” represent the frontiers of research in this field, undergoing an explosive phase. Conclusion These findings offer valuable insights for researchers to further investigate the involvement of neuroimmune mechanisms in psoriasis.

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Efficacy and safety assessment of netakimab in scalp psoriasis

Kurdina,

Kolenko

2023

Medicinskij sovet

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Introduction. Scalp psoriasis is a common disease that has a long, recurrent course with severe desquamation, dryness and itching of the skin. The location of the pathological process in an aesthetically significant area, constant therapy leads to low satisfaction and adherence to treatment and, as a result, to a pronounced decrease in the quality of life.Aim. To study the efficacy and safety of netakimab in psoriasis of the scalp.Materials and methods. 52 adult patients (n = 52) with psoriasis of the face and scalp were under observation. The severity of the psoriatic lesion of the scalp was determined using the PSSI index (Psoriasis Severity Scalp Index). The assessment was carried out before the start of treatment, in the first week, and then every 4 weeks up to and including 52 weeks. The Dermatological Quality of Life Index (DLQI) – were determined by questionnaires before the start of treatment, at the 12th and 52nd weeks. All patients on an outpatient basis received netakimab monotherapy at a dose of 120 mg in the form of two subcutaneous injections of 1 ml (60 mg) of the drug, each administered once a week at weeks 0, 1 and 2, then 1 time every 4 weeks. The total duration of treatment for each patient was 1 year (52 weeks). The safety of netakimab was evaluated based on the development of adverse events and local reactions to the administration of the drug.Results. The results of the study (n = 52) for 52 weeks showed high efficacy of netakimab. 48% of patients achieved PSSI 90 by the week 12 of treatment and 77% of patients achieved PSSI 90 by the week 52, itching of the scalp significantly decreased and the quality of life improved. During the 52 weeks of the study, there were no cases of early withdrawal due to adverse events and cases of serious adverse events.Conclusion. Based on the study results we recommend netakimab for medical use among patients with moderate and severe scalp psoriasis.

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Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch

Cited by 5 publications

References 24 publications

Current and emerging drugs for the treatment of pruritus: an update of the literature

Current and emerging drugs for the treatment of pruritus: an update of the literature

Knowledge mapping of the relationship between neuroimmune and psoriasis： A Bibliometric analysis（2004-2023）

Efficacy and safety assessment of netakimab in scalp psoriasis

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