Neuroimmune mechanisms in autism etiology - untangling a complex problem using human cellular models
Janay M Vacharasin,
Joseph A Ward,
Mikayla M McCord
et al.
Abstract:Autism spectrum disorders (ASD) affect 1 in 36 people and is more often diagnosed in males than in females. Core features of ASD are impaired social interactions, repetitive behaviors and deficits in verbal communication. ASD is a highly heterogeneous and heritable disorder, yet its underlying genetic causes account only for up to 80% of the cases. Hence, a subset of ASD cases could be influenced by environmental risk factors. Maternal immune activation (MIA) is a response to inflammation during pregnancy, whi… Show more
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