Neuroimmune interactions in painful TMD: Mechanisms and treatment implications

Yi, Yating; Zhou, Xueman; Xiong, Xin; Wang, Jun

doi:10.1002/jlb.3mr0621-731rr

Cited by 5 publications

(4 citation statements)

References 128 publications

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“…Degenerative joint disease (DJD) is a chronic, debilitating disease characterised by degeneration of the articular cartilage and changes in the subchondral bone and soft tissues, which are associated with pain and dysfunction, compromising the quality of life for patients. 1,2 A series of inflammatory processes contribute to the pathogenesis of joint degeneration. 3 Overload exceeding the adaptive remodelling of the temporomandibular joint (TMJ) may lead to secondary inflammation.…”

Section: Backg Rou N Dmentioning

confidence: 99%

Risk estimation of degenerative joint disease in temporomandibular disorder patients with different types of sagittal and coronal disc displacements: MRI and CBCT analysis

Fan

Xiong

Cheng

et al. 2022

J of Oral Rehabilitation

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Background Degenerative joint disease (DJD) can be associated with disc displacement (DD) in temporomandibular disorder (TMD) patients. However, the relationship between different types of DDs and DJD remains unclear. Objectives To investigate the odds ratios of different types of sagittal and coronal DDs confirmed by magnetic resonance imaging (MRI) and DJD confirmed by cone‐beam computed tomography (CBCT) in TMD patients. Methods Radiographic data from 69 males and 232 females were collected for analysis. CBCT was used to diagnose DJD, with criteria including erosion, osteophytes, generalised sclerosis and cysts in the joint. Eight types of DDs were evaluated by sagittal and coronal MRIs: NA, no abnormality; SW, sideways; ADDR, anterior with reduction; ADDR+SW; ADDNR, anterior without reduction; ADDNR + SW; single SW; PDD, posterior; PDD + SW. The odds ratios of DJD in joints with different types of DDs were determined after joint correlation, age and gender adjustment. Results Compared with NA, the odds ratio of DJD in ADDR was 2.397 (95% CI [confidence interval]: 1.070–5.368), ADDR + SW was 4.808 (95% CI: 1.709–3.528), ADDNR was 29.982 (95% CI: 15.512–57.950) and ADDNR + SW was 25.974 (95% CI: 12.743–52.945). Erosion was significantly increased in ADDR, ADDR + SW, ADDNR and ADDNR + SW; osteophytes were significantly increased in ADDR + SW, ADDNR and ADDNR + SW; and generalised sclerosis and cysts were significantly increased in ADDNR and ADDNR + SW. There were no significant associations between single SW, PDD, PDD + SW and the DJD. Conclusions ADDR, ADDR+SW, ADDNR and ADDNR+SW were associated with DJD. ADDNR had a significantly higher prevalence of DJD than ADDR. There were no significant relationships between single SW, PDD, PDD + SW and the DJD.

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Section: Backg Rou N Dmentioning

confidence: 99%

Risk estimation of degenerative joint disease in temporomandibular disorder patients with different types of sagittal and coronal disc displacements: MRI and CBCT analysis

Fan

Xiong

Cheng

et al. 2022

J of Oral Rehabilitation

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“…And 11% of the TMD patients have symptoms of osteoarthritis [ 4 ]. As a primary chief complaint of TMJOA patients, pain and TMJ dysfunction could compromise the quality of life of patients, causing a considerable social and economic burden [ 5 , 6 ]. However, the etiology of TMJOA is not yet completely understood.…”

Section: Introductionmentioning

confidence: 99%

Hyoid Bone Position in Patients with and without Temporomandibular Joint Osteoarthrosis: A Cone-Beam Computed Tomography and Cephalometric Analysis

Zhou

Xiong

Yan

et al. 2021

Pain Research and Management

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Objective. To assess the differences in hyoid bone position in patients with and without temporomandibular joint osteoarthrosis (TMJOA). Methods. The present cross-sectional study was conducted in 427 participants whose osseous status was evaluated using cone-beam computed tomography and classified into normal, indeterminate osteoarthrosis (OA), and OA. The hyoid bone position and craniofacial characteristics were evaluated using cephalograms. Patients were divided into the normal group (N = 89), indeterminate OA group (N = 182), and OA group (N = 156). Descriptive statistics, one-way analysis of variance, and age- and sex-based stratified analyses were performed. P < 0.05 was considered statistically significant. Results. The differences in Hy to MP, Hy-RGn, Hy to C3-RGn, C3-RGn, and Go-Hy-Me among the three groups were statistically significant. The differences in the Frankfort-mandibular plane angle, saddle angle, articular angle, gonial angle, ramus height, and posterior facial height were statistically significant. After adjusting age and sex, the Hy-RGn and C3-RGn in the normal group were significantly greater than the OA group. No statistical differences were observed in the hyoid measurements in the stratified analyses in males or subjects less than 18 years old. The differences in Hy to MP, Hy to C3-RGn, and Go-Hy-Me in female patients among the three groups were statistically significant. The differences in Hy to SN, Hy to FH, Hy to PP, Hy to MP, Hy-RGn, Hy-C3, Hy to C3-RGn, Go-Hy-Me, Hy-S, and C3-Hy-S in adults were statistically significant. Conclusion. The differences in the hyoid bone position, mainly relative to the mandible, were statistically significant in patients with or without TMJOA. The difference pattern varied among different age and sex groups. Clinical evaluation of the hyoid position must consider the age and sex of patients. Longitudinal studies are required to clarify the causal relationship between TMJOA and hyoid bone position.

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“…Similar symptoms with peripheral and TMJ OA cause joint pain and movement limitation. Different from peripheral joint OA, TMJ OA is the terminal stage of TMJ disorder and often presents with abnormal jaw movement and restricted mouth opening, partly accompanied by tinnitus, headache, and other symptoms ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint

Yang

Li²,

Fu³

et al. 2023

Front. Endocrinol.

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Osteoarthritis (OA) is a disabling disease with significant morbidity worldwide. OA attacks the large synovial joint, including the peripheral joints and temporomandibular joint (TMJ). As a representative of peripheral joint OA, knee OA shares similar symptoms with TMJ OA. However, these two joints also display differences based on their distinct development, anatomy, and physiology. Extracellular vesicles (EVs) are phospholipid bilayer nanoparticles, including exosomes, microvesicles, and apoptotic bodies. EVs contain proteins, lipids, DNA, micro-RNA, and mRNA that regulate tissue homeostasis and cell-to-cell communication, which play an essential role in the progression and treatment of OA. They are likely to partake in mechanical response, extracellular matrix degradation, and inflammatory regulation during OA. More evidence has shown that synovial fluid and synovium-derived EVs may serve as OA biomarkers. More importantly, mesenchymal stem cell-derived EV shows a therapeutic effect on OA. However, the different function of EVs in these two joints is largely unknown based on their distinct biological characteristic. Here, we reviewed the effects of EVs in OA progression and compared the difference between the knee joint and TMJ, and summarized their potential therapeutic role in the treatment of OA.

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Neuroimmune interactions in painful TMD: Mechanisms and treatment implications

Cited by 5 publications

References 128 publications

Risk estimation of degenerative joint disease in temporomandibular disorder patients with different types of sagittal and coronal disc displacements: MRI and CBCT analysis

Risk estimation of degenerative joint disease in temporomandibular disorder patients with different types of sagittal and coronal disc displacements: MRI and CBCT analysis

Hyoid Bone Position in Patients with and without Temporomandibular Joint Osteoarthrosis: A Cone-Beam Computed Tomography and Cephalometric Analysis

Extracellular vesicles in osteoarthritis of peripheral joint and temporomandibular joint

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