Neuroimmune Advance in Depressive Disorder

Zhao, Guangsheng; Liu, Xiaohua

doi:10.1007/978-981-32-9271-0_4

Cited by 16 publications

(13 citation statements)

References 57 publications

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“…According to reference co-citation network analysis, all the top 10 highly co-cited references were located in the largest theme cluster #0, "cytokines, " which formed an important basis for studies in this field. Mounting evidence suggests that the levels of some pro-inflammatory cytokines [e.g., interleukin (IL)-1β, IL-6, IL-18, and tumor necrosis factor (TNF)-α] are increased in depressive disorder, whereas some antiinflammatory cytokines [e.g., IL-10 and transforming growth factor (TGF)-β1] are decreased (73,74). Some meta-analyses have provided evidence that the alterations in the levels of peripheral cytokine (e.g., IL-8, TNF-α, IL-6, and IL-10) are associated with the antidepressant treatment response in patients with major depressive disorder (MDD) (75,76).…”

Section: Discussionmentioning

confidence: 99%

Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019

Zhu

Deng

et al. 2021

Front. Psychiatry

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Background: There is a crucial link between the gut microbiota and the host central nervous system, and the communication between them occurs via a bidirectional pathway termed the “microbiota-gut-brain axis.” The gut microbiome in the modern environment has markedly changed in response to environmental factors. These changes may affect a broad range of host psychiatric disorders, such as depression, by interacting with the host through metabolic, immune, neural, and endocrine pathways. Nevertheless, the general aspects of the links between the gut microbiota and depression have not been systematically investigated through bibliometric analysis.Aim: This study aimed to analyze the current status and developing trends in gut microbiota research in the depression field through bibliometric and visual analysis.Methods: A total of 1,962 publications published between 1999 and 2019 were retrieved from the Web of Science Core Collection. CiteSpace (5.6 R5) was used to perform collaboration network analysis, co-citation analysis, co-occurrence analysis, and citation burst detection.Results: The number of publications has been rapidly growing since 2010. The collaboration network analysis revealed that the USA, University College Cork, and John F. Cryan were the most influential country, institute, and scholar, respectively. The most productive and co-cited journals were Brain Behavior and Immunity and Proceedings of the National Academy of Sciences of the United States of America, respectively. The co-citation analysis of references revealed that the most recent research focus was in the largest theme cluster, “cytokines,” thus reflecting the important research foundation in this field. The co-occurrence analysis of keywords revealed that “fecal microbiota” and “microbiome” have become the top two research hotspots since 2013. The citation burst detection for keywords identified several keywords, including “Parkinson's disease,” “microbiota-gut-brain axis,” “microbiome,” “dysbiosis,” “bipolar disorder,” “impact,” “C reactive protein,” and “immune system,” as new research frontiers, which have currently ongoing bursts.Conclusions: These results provide an instructive perspective on the current research and future directions in the study of the links between the gut microbiota and depression, which may help researchers choose suitable cooperators or journals, and promote their research illustrating the underlying molecular mechanisms of depression, including its etiology, prevention, and treatment.

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Section: Discussionmentioning

confidence: 99%

Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019

Zhu

Deng

et al. 2021

Front. Psychiatry

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“…A large body of evidence suggests that inflammation has central role in pathogenesis of MDD [7][8][9][10][11][12][13]. However, the exact mechanisms underlying inflammation-induced depression are not completely elucidated [3].…”

Section: Introductionmentioning

confidence: 99%

On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?

Roohi

Jaafari

Hashemian

2021

J Neuroinflammation

104

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Many patients with major depressive disorder (MDD) are reported to have higher levels of multiple inflammatory cytokines including interleukin 6 (IL-6). Recent studies both pre-clinical and clinical have advocated for the functional role of IL-6 in development of MDD and suggested a great potential for targeting this cytokine to open new avenues in pharmacotherapy of depression. The purpose of the present narrative review was to provide an integrated account of how IL-6 may contribute to development of depression. All peer-reviewed journal articles published before July 2020 for each area discussed were searched by WOS, PubMed, MEDLINE, Scopus, Google Scholar, for original research, review articles, and book chapters. Publications between 1980 and July 2020 were included. Alterations in IL-6 levels, both within the periphery and the brain, most probably contribute to depression symptomatology in numerous ways. As IL-6 acts on multiple differing target tissues throughout the body, dysregulation of this particular cytokine can precipitate a multitude of events relevant to depression and blocking its effects can prevent further escalation of inflammatory responses, and potentially pave the way for opening new avenues in diagnosis, treatment, and prevention of this debilitating disorder.

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“…Early evidence found that patients with autoimmune or infectious diseases are more likely to develop depression than the general population [ 54 ]. In addition, individuals without depression may display depressive symptoms after treatment with cytokines or cytokine inducers, while antidepressants relieve these symptoms [ 55 , 56 ]. There is a complex interaction between the peripheral and central immune systems.…”

Section: Neurobiological Pathogenesis Of Depressive Disordermentioning

confidence: 99%

Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications

et al. 2021

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Major depressive disorder (MDD), also referred to as depression, is one of the most common psychiatric disorders with a high economic burden. The etiology of depression is still not clear, but it is generally believed that MDD is a multifactorial disease caused by the interaction of social, psychological, and biological aspects. Therefore, there is no exact pathological theory that can independently explain its pathogenesis, involving genetics, neurobiology, and neuroimaging. At present, there are many treatment measures for patients with depression, including drug therapy, psychotherapy, and neuromodulation technology. In recent years, great progress has been made in the development of new antidepressants, some of which have been applied in the clinic. This article mainly reviews the research progress, pathogenesis, and treatment of MDD.

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Neuroimmune Advance in Depressive Disorder

Cited by 16 publications

References 57 publications

Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019

Bibliometric and Visual Analysis of Research on the Links Between the Gut Microbiota and Depression From 1999 to 2019

On inflammatory hypothesis of depression: what is the role of IL-6 in the middle of the chaos?

Major Depressive Disorder: Advances in Neuroscience Research and Translational Applications

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