Neuroimaging variables related to development of Secondary Attention Deficit Hyperactivity Disorder after closed head injury in children and adolescents

Gerring, Joan P.; Brady, Kathleen D.; Chen, Anita; Quinn, Cynthia B.; Herskovits, Edward H.; Bandeen‐Roche, Karen; Denckla, Martha B.; Bryan, R. Nick

doi:10.1080/026990500120682

Cited by 59 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Poorer preinjury family function and greater premorbid psychosocial adversity is associated with postinjury ADHD symptoms and SADHD [20, 48, 49]. Brain correlates of SADHD include right putamen or thalamic lesions [50, 51], and orbital frontal gyrus lesions [46]. These anatomical findings suggest that lesions in varied locations along specific cortico-striatal-pallidal-thalamic loops may generate a clinical syndrome of SADHD.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychiatry of Pediatric Traumatic Brain Injury

Max

2014

Psychiatric Clinics of North America

View full text Add to dashboard Cite

Synopsis Pediatric traumatic brain injury (TBI) is a major public health problem. Psychiatric disorders with onset before the injury appear to be more common than population base rates. Novel (postinjury onset) psychiatric disorders (NPD) are also common and complicate child function after injury. Novel disorders include personality change due to TBI, secondary attention-deficit/hyperactivity disorder (SADHD), as well as other disruptive behavior disorders, and internalizing disorders. This article reviews preinjury psychiatric disorders as well as biopsychosocial risk factors and treatments for NPD.

show abstract

Section: Introductionmentioning

confidence: 99%

Neuropsychiatry of Pediatric Traumatic Brain Injury

Max

2014

Psychiatric Clinics of North America

View full text Add to dashboard Cite

show abstract

“…Trauma to the thalamus and basal ganglia, for example, can produce new-onset ADHD symptoms in children and adolescents (23). Functional imaging studies have shown that activation of distributed portions of CSTC circuits, including the thalamus, is abnormal in individuals with ADHD (6).…”

mentioning

confidence: 99%

Morphological Abnormalities of the Thalamus in Youths With Attention Deficit Hyperactivity Disorder

Ivanov

Bansal

Hao

et al. 2010

AJP

147

107

View full text Add to dashboard Cite

Objective The role of the thalamus in the genesis of attention deficit hyperactivity disorder (ADHD) remains poorly understood. The authors used anatomical MRI to examine the morphology of the thalamus in youths with ADHD and healthy comparison youths. Method The authors examined 46 youths with ADHD and 59 comparison youths 8–18 years of age in a cross-sectional case-control study. Conventional volumes and measures of surface morphology of the thalamus served as the main outcome measures. Results A mixed-effects model comparing whole thalamic volumes revealed no significant differences between groups. Maps of the thalamic surface revealed significantly smaller regional volumes bilaterally in the pulvinar in youths with ADHD relative to comparison subjects. Post hoc analyses showed that ADHD patients who received stimulants (N=31) had larger conventional thalamic volumes than untreated youths with ADHD, and maps of the thalamic surface showed enlargement over the pulvinar in those receiving stimulants. Smaller regional volumes in the right lateral and left posterior thalamic surfaces were associated with more severe hyperactivity symptoms, whereas larger regional volumes in the right medial thalamic surfaces were associated with more severe symptoms of inattention. Conclusion These findings demonstrate reduced pulvinar volumes in youths with ADHD and indicate that this same area is relatively enlarged in patients treated with stimulants compared to those untreated. Associations of hyperactivity scores with smaller regional volumes on the lateral thalamic surface and inattention scores with larger regional volumes on the medial thalamic surface suggest the differential involvement of thalamic subcircuits in the pathogenesis of differing ADHD symptoms.

show abstract

“…Herskovits et al [1999] reported an association between lesions within the right putamen detected 3 months after TBI and diagnosis of secondary ADHD 1 year after TBI. In an overlapping cohort, Gerring et al [2000] found that for children with thalamus and/or basal ganglia injury, the odds of developing secondary ADHD were three times higher than among children without injuries identified in those regions. In contrast, other groups have not found associations between number and/or location of injury and development of features of secondary ADHD [Leblanc et al, 2005; Max et al, 2005].…”

Section: Magnetic Resonance Imagingmentioning

confidence: 96%

Neuroimaging in pediatric traumatic brain injury: Current and future predictors of functional outcome

Suskauer

Huisman

2009

Dev Disabil Res Revs

View full text Add to dashboard Cite

Although neuroimaging has long played a role in the acute management of pediatric traumatic brain injury (TBI), until recently, its use as a tool for understanding and predicting long-term brain-behavior relationships after TBI has been limited by the relatively poor sensitivity of routine clinical imaging for detecting diffuse axonal injury (DAI). Newer magnetic resonance-based imaging techniques demonstrate improved sensitivity to DAI. Early research suggests that these techniques hold promise for identifying imaging predictors and correlates of chronic function, both globally and within specific neuropsychological domains. In this review, we describe the principles of new, advanced imaging techniques including diffusion weighted and diffusion tensor imaging, susceptibility weighted imaging, and 1H-magnetic resonance spectroscopy. In addition, we summarize current research demonstrating their early success in establishing relationships between imaging measures and functional outcomes after TBI. With the ongoing research, these imaging techniques may allow earlier identification of possible chronic sequelae of tissue injury for each child with TBI, thereby facilitating efficacy and efficiency in delivering successful rehabilitation services.

show abstract

Neuroimaging variables related to development of Secondary Attention Deficit Hyperactivity Disorder after closed head injury in children and adolescents

Abstract: The data support an association between S-ADHD and injury in either or both the thalamus and basal ganglia, but they do not definitively demonstrate whether injury in either structure has an effect on S-ADHD in the absence of injury in the other.

Cited by 59 publications

References 18 publications

Neuropsychiatry of Pediatric Traumatic Brain Injury

Neuropsychiatry of Pediatric Traumatic Brain Injury

Morphological Abnormalities of the Thalamus in Youths With Attention Deficit Hyperactivity Disorder

Neuroimaging in pediatric traumatic brain injury: Current and future predictors of functional outcome

Contact Info

Product

Resources

About