Neuroimaging study on brain asymmetries in situs inversus totalis

Ihara, Atsushi; Hirata, Masayuki; Fujimaki, Norio; Goto, Tetsu; Umekawa, Yuka; Fujita, Norihiko; Terazono, Yasushi; Matani, Ayumu; Wei, Qiang; Yoshimine, Toshiki; Yorifuji, Shiro; Matsumoto, Tsutomu

doi:10.1016/j.jns.2009.10.002

Cited by 34 publications

(38 citation statements)

References 37 publications

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“…This is in line with the suggestion by Brandler et al (2013), who claim that handedness is partially controlled by the molecular mechanisms that establish body asymmetry during early development. This finding has been supported by neuroimaging studies of patients with situs inversus, who displayed atypical patterns of frontal and occipital cerebral asymmetries (Kennedy et al, 1999; Ihara et al, 2010). However, situs inversus patients display the standard pattern of handedness, which rather supports a dissociation between visceral and brain asymmetries (Matsumoto et al, 1997; McManus et al, 2004; Afzelius and Stenram, 2006).…”

Section: Discussionmentioning

confidence: 62%

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

et al. 2017

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Handedness and language lateralization are partially determined by genetic influences. It has been estimated that at least 40 (and potentially more) possibly interacting genes may influence the ontogenesis of hemispheric asymmetries. Recently, it has been suggested that analyzing the genetics of hemispheric asymmetries on the level of gene ontology sets, rather than at the level of individual genes, might be more informative for understanding the underlying functional cascades. Here, we performed gene ontology, pathway and disease association analyses on genes that have previously been associated with handedness and language lateralization. Significant gene ontology sets for handedness were anatomical structure development, pattern specification (especially asymmetry formation) and biological regulation. Pathway analysis highlighted the importance of the TGF-beta signaling pathway for handedness ontogenesis. Significant gene ontology sets for language lateralization were responses to different stimuli, nervous system development, transport, signaling, and biological regulation. Despite the fact that some authors assume that handedness and language lateralization share a common ontogenetic basis, gene ontology sets barely overlap between phenotypes. Compared to genes involved in handedness, which mostly contribute to structural development, genes involved in language lateralization rather contribute to activity-dependent cognitive processes. Disease association analysis revealed associations of genes involved in handedness with diseases affecting the whole body, while genes involved in language lateralization were specifically engaged in mental and neurological diseases. These findings further support the idea that handedness and language lateralization are ontogenetically independent, complex phenotypes.

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Section: Discussionmentioning

confidence: 62%

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

et al. 2017

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“…In humans the relation between visceral and brain asymmetry is also complex. As noted above, people with a complete reversal of the left/right pattern of the visceral organs in Kartagener syndrome (a primary ciliary dyskinesia) have shown the same proportions of cerebral dominance for handedness and auditory language dominance as the general population 53,54 , except when the sample size was extremely small (3 patients) 72 . However, some structural asymmetries of the brain may be reversed in people with reversed visceral laterality, although again the sample sizes in these studies have been extremely small 73,74 .…”

Section: Resultsmentioning

confidence: 93%

Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains

Kovel

Lisgo

Fisher

et al. 2018

Sci Rep

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Left-right laterality is an important aspect of human –and in fact all vertebrate– brain organization for which the genetic basis is poorly understood. Using RNA sequencing data we contrasted gene expression in left- and right-sided samples from several structures of the anterior central nervous systems of post mortem human embryos and foetuses. While few individual genes stood out as significantly lateralized, most structures showed evidence of laterality of their overall transcriptomic profiles. These left-right differences showed overlap with age-dependent changes in expression, indicating lateralized maturation rates, but not consistently in left-right orientation over all structures. Brain asymmetry may therefore originate in multiple locations, or if there is a single origin, it is earlier than 5 weeks post conception, with structure-specific lateralized processes already underway by this age. This pattern is broadly consistent with the weak correlations reported between various aspects of adult brain laterality, such as language dominance and handedness.

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“…However, some observations suggest that a few links between body and brain asymmetries may exist and need to be investigated further. For instance, two independent studies, on six SI individuals in total, found a systematic reversion in the structural asymmetry of the frontal and occipital petalia (83,87); in contrast, the asymmetry in the PT was not reversed in these SI subjects. In a recent GWAS, Brandler et al (20) found an enrichment of SNPs in four genes involved in ciliogenesis (GLI3, MNS1, RFX3, and PDK2) that are strongly associated with relative hand skills.…”

Section: A Link Between Body and Brain Lateralitymentioning

confidence: 99%

Asymmetry of the Brain: Development and Implications

et al. 2015

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Although the left and right hemispheres of our brains develop with a high degree of symmetry at both the anatomical and functional levels, it has become clear that subtle structural differences exist between the two sides and that each is dominant in processing specific cognitive tasks. As the result of evolutionary conservation or convergence, lateralization of the brain is found in both vertebrates and invertebrates, suggesting that it provides significant fitness for animal life. This widespread feature of hemispheric specialization has allowed the emergence of model systems to study its development and, in some cases, to link anatomical asymmetries to brain function and behavior. Here, we present some of what is known about brain asymmetry in humans and model organisms as well as what is known about the impact of environmental and genetic factors on brain asymmetry development. We specifically highlight the progress made in understanding the development of epithalamic asymmetries in zebrafish and how this model provides an exciting opportunity to address brain asymmetry at different levels of complexity.

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Neuroimaging study on brain asymmetries in situs inversus totalis

Cited by 34 publications

References 37 publications

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

The Functional Genetics of Handedness and Language Lateralization: Insights from Gene Ontology, Pathway and Disease Association Analyses

Subtle left-right asymmetry of gene expression profiles in embryonic and foetal human brains

Asymmetry of the Brain: Development and Implications

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