Neuroimaging Studies of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Zhao, Yifan; Lin, Jiaqi; Ye, Dong; Tian, Zilei; Yan, Yonghong; Ma, Ziyang; Xia, Shengli; Huang, Xiaopeng; Chen, Diang; Zhang, Peihai

doi:10.1155/2022/9448620

Cited by 10 publications

(7 citation statements)

References 27 publications

(28 reference statements)

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“…34 Another study found reciprocal relationships between pelvic pain and negative mood, such that negative mood changes directly corresponded with increased symptoms 2 weeks later and vice versa. 35 Interacting emotional and cognitive processes 36 are critical components of the pathophysiology of chronic pain as demonstrated by both clinical studies and a growing neuroimaging literature 37,38 that implicates cognitive control brain networks governing emotional and pain responses underlying UCPPS. For example, a recent prospective study demonstrated that increased connectivity in frontal parietal cognitive control networks predicted UCPPS pain reduction over 3 months, supporting the important role of cognitive factors modulating symptoms.…”

Section: The Science Of Pelvic Pain "Chronification"mentioning

confidence: 99%

Cognitive Behavioral Therapy for Chronic Pelvic Pain: What Is It and Does It Work?

Lackner,

Clemens,

Radziwon

et al. 2024

Journal of Urology

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Purpose: Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome in women and men and chronic prostatitis/chronic pelvic pain syndrome in men, is a common, often disabling urological disorder that is neither well understood nor satisfactorily treated with medical treatments. The past 25 years have seen the development and validation of a number of behavioral pain treatments, of which cognitive behavioral therapy (CBT) is arguably the most effective. CBT combines strategies of behavior therapy, which teaches patients more effective ways of behaving, and cognitive therapy, which focuses on correcting faulty thinking patterns. As a skills-based treatment, CBT emphasizes "unlearning" maladaptive behaviors and thoughts, and replacing them with more adaptive ones that support symptom selfmanagement. Materials and Methods: This review describes the rationale, technical procedures, and empirical basis of CBT. Results: While evidence supports CBT for treatment-refractory chronic pain disorders, there is limited understanding of why or how CBT might work, for whom it is most beneficial, or the specific UCPPS symptoms (eg, pain, urinary symptoms) it effectively targets. This is the focus of EPPIC (Easing Pelvic Pain Interventions Clinical Research Program), a landmark NIH trial examining the efficacy of low-intensity, home-based CBT for UCPPS relative to a nonspecific comparator featuring self-care recommendations of AUA guidelines. Conclusions: Systematic efforts to increase both the efficiency of CBT and the way it is delivered (eg, home-based treatments) are critical to scaling up CBT, optimizing its therapeutic potential, and reducing the public health burden of UCPPS.UROLOGIC chronic pelvic pain syndrome (UCPPS), encompassing interstitial cystitis/bladder pain syndrome (IC/BPS) in women and men and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men, is estimated to affect nearly 5 million Americans.

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Section: The Science Of Pelvic Pain "Chronification"mentioning

confidence: 99%

Cognitive Behavioral Therapy for Chronic Pelvic Pain: What Is It and Does It Work?

Lackner,

Clemens,

Radziwon

et al. 2024

Journal of Urology

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“…This technology has played a significant role in reshaping our understanding of chronic pain as a degenerative disease [ 22 ]. The findings of Zhao et al highlight the advancements in neuroimaging techniques that have shed light on brain alterations in individuals with chronic pain disorders such as chronic prostatitis/chronic pelvic pain syndrome and chronic low back pain [ 53 ]. Recent investigations into chronic prostatitis/chronic pelvic pain syndrome mechanisms have centered on elucidating crucial pathological features.…”

Section: Reviewmentioning

confidence: 99%

The Role of the Insula in Chronic Pain and Associated Structural Changes: An Integrative Review

McBenedict,

Petrus,

Pires

et al. 2024

Cureus

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Chronic pain affects a substantial portion of the global population, significantly impacting quality of life and well-being. This condition involves complex mechanisms, including dysfunction of the autonomic nervous system, which plays a crucial role in pain perception. The insula, a key brain region involved in pain processing, plays a critical role in pain perception and modulation. Lesions in the insula can result in pain asymbolia, where pain perception remains intact but emotional responses are inappropriate. The insula is anatomically and functionally divided into anterior and posterior regions, with the posterior insula processing nociceptive input based on intensity and location before relaying it to the anterior insula for emotional mediation. Understanding the insula's intricate role in pain processing is crucial, as it is involved in encoding prediction errors and mediating emotional dimensions of pain perception. The focus of this review was on synthesizing existing literature on the role of the insula in chronic pain and associated structural changes. The goal was to integrate findings from various sources to provide a comprehensive overview of the topic. The search strategy included a combination of Medical Subject Headings (MeSH) and relevant keywords related to insula and chronic pain. The following databases were surveyed: PubMed, Embase, Scopus, and Web of Science. We identified a total of 2515 articles, and after following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline based on eligibility criteria, 46 articles were used to synthesize this review. Our study highlights the pivotal role of the insula in chronic pain processing and associated structural changes, integrating findings from diverse studies and neuroimaging investigations. Beyond mere pain sensation, the insula contributes to emotional awareness, attention, and salience detection within the pain network. Various chronic pain conditions reveal alterations in insular activity and connectivity, accompanied by changes in gray matter volume and neurochemical profiles. Interventions targeting the insula show promise in alleviating chronic pain symptoms. However, further research is needed to understand underlying mechanisms, which can aid in developing more effective therapeutic interventions for pain.

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“…Betroffene zeigen eine lokale und überregionale Hypersensitivität. Wie auch bei anderen chronischen Schmerzsyndromen zeigt sich in der MRT-Bildgebung eine relative Reduktion der grauen Substanz im anterioren Zingulum 14 . Unklar bleibt es in den meisten Fällen, ob eine periphere Störung zu einer Dysfunktion des Schmerzsystems oder ob die Dysfunktion des Schmerzsystems zu einer peripheren Störung führt.…”

Section: Chronischer Beckenbodenschmerzunclassified

Behandlung des chronischen Beckenschmerzsyndroms (CPPS) und der chronischen Prostatitis (CP)

Peuker

2023

AkupunkturPraxis

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Urologische Erkrankungen betreffen ein großes Klientel auch außerhalb der fachärztlichen Versorgung. Das chronische Beckenschmerzsyndrom (CPPS) ist eine der häufigsten Erkrankungen in der Urologie und Gynäkologie und spielt auch in der allgemeinmedizinischen und schmerztherapeutischen Praxis eine große Rolle. Die chronische Prostatitis als Unterform des CPPS stellt die häufigste urologische Diagnose beim unter 50-jährigen Mann dar und zeigt sich häufig therapierefraktär. Hier kann die Akupunktur für sich und im Zusammenspiel mit anderen Therapieverfahren nachweislich und neurophysiologisch gut erklärbar zur Beschwerdelinderung beitragen.

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Neuroimaging Studies of Chronic Prostatitis/Chronic Pelvic Pain Syndrome

Cited by 10 publications

References 27 publications

Cognitive Behavioral Therapy for Chronic Pelvic Pain: What Is It and Does It Work?

Cognitive Behavioral Therapy for Chronic Pelvic Pain: What Is It and Does It Work?

The Role of the Insula in Chronic Pain and Associated Structural Changes: An Integrative Review

Behandlung des chronischen Beckenschmerzsyndroms (CPPS) und der chronischen Prostatitis (CP)

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