Neuroimaging of Visceral Pain

Johns, Emily; Tracey, Irene

doi:10.1177/204946370900300202

Cited by 6 publications

(3 citation statements)

References 20 publications

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“…Therefore, slightly different results were reported on the characteristics of the activation of certain regions of the cortex in response to visceral and somatic pain. Findings of this work compliment and amplify the available data on differential perception of visceral and somatic pain in the brain (Strigo et al, 2003; Apkarian et al, 2005; Dunckley et al, 2005; Derbyshire, 2007; Johns and Tracey, 2009; Gebhart and Bielefeldt, 2016).…”

Section: Discussionsupporting

confidence: 82%

Contactless Assessment of Cerebral Autoregulation by Photoplethysmographic Imaging at Green Illumination

et al. 2019

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Accurate and practical assessment of the brain circulation is needed to adequately estimate the viability of cerebral blood flow regulatory mechanisms in various physiological conditions. The objective of our study was to examine feasibility of the contactless green-light imaging photoplethysmography (PPG) for assessing cerebral autoregulation by revealing the dynamic relationships between cortical microcirculation assessed by PPG and changes in systemic blood pressure caused by visceral and somatic peripheral stimuli. In anesthetized male Wistar rats, the PPG video images of the open parietal cortex (either with unimpaired or dissected dura mater), electrocardiogram, and systemic arterial blood pressure (ABP) in the femoral artery were continuously recorded before, during and after visceral (colorectal distension) or somatic (tail squeezing) stimulation. In the vast majority of experiments with intact and removed dura mater, both spontaneous and peripheral stimulation-evoked changes in ABP negatively correlated with the accompanying alterations in the amplitude of pulsatile PPG component (APC), i.e., an increase of ABP resulted in a decrease of APC and vice versa. The most pronounced ABP and APC alterations were induced by noxious stimuli. Visceral painful stimulation in all cases caused short-term hypotension with simultaneous increase in cortical APC, whereas somatic noxious stimuli in 8 of 21 trials produced hypertensive effect with decreased APC. Animals with pressure 50-70 mmHg possessed higher negative cerebrovascular response rate of ABP-APC gradients than rats with either lower or higher pressure. Severe hypotension reversed the negative ratio to positive one, which was especially evident under visceral pain stimulation. Amplitude of the pulsatile PPG component probably reflects the regulation of vascular tone of cerebral cortex in response to systemic blood pressure fluctuations. When combined with different kinds of peripheral stimuli, the technique is capable for evaluation of normal and elucidation of impaired cerebrovascular system reactivity to particular physiological events, for example pain. The reported contactless PPG monitoring of cortical circulatory dynamics during neurosurgical interventions in combination with recordings of changes in other physiological parameters, such as systemic blood pressure and ECG, has the appealing potential to monitor viability of the cortex vessels and determine the state of patient’s cerebrovascular autoregulation.

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Section: Discussionsupporting

confidence: 82%

Contactless Assessment of Cerebral Autoregulation by Photoplethysmographic Imaging at Green Illumination

et al. 2019

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“…These results con rmed the utility of machine learning approaches in the analysis of multidimensional EEG/LFP data from the brain. From a biological perspective, these results indicate that LFP patterns related to visceral pain are not merely evoked by single brain regions, but rather emerge from widespread neural networks across multiple brain areas 27 .…”

Section: Discussionmentioning

confidence: 90%

Transformer-based classification of visceral pain-related local field potential patterns in the brain

Kayama,

Tamura,

Xiaoying

et al. 2024

Preprint

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Neuronal ensemble activity entrained by local field potential (LFP) patterns underlies a variety of brain functions, including emotion, cognition, and pain perception. Recent advances in machine learning approaches may enable more effective methods for analyzing LFP patterns across multiple brain areas than conventional time-frequency analysis. In this study, we tested the performance of two machine learning algorithms, AlexNet and the Transformer models, to classify LFP patterns in eight pain-related brain regions before and during acetic acid-induced visceral pain behaviors. Over short time windows lasting several seconds, applying AlexNet to LFP power datasets, but not to raw time-series LFP traces from multiple brain areas, successfully achieved superior classification performance compared with simple LFP power analysis. Furthermore, applying the Transformer directly to the raw LFP traces achieved significantly superior classification performance than AlexNet when using LFP power datasets. These results demonstrate the utility of the Transformer in the analysis of neurophysiological signals, and pave the way for its future applications in the decoding of more complex neuronal activity patterns.

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“…Although we could image a weak HA signal in the sensory fibers projecting to the spinal cord or the gut, the hM4Di receptor was not found in the soma of nonneuronal cells of the CNS (Figure 2E) and in the colon (Figure 2F). Finally, we did not observe DREADD expression in the anterior cingulate cortex and the somatosensory cortex, which are key brain areas involved in the perception of pain 31 (Figure 2G).…”

Section: Generation Of Trpv1-dreadd Micementioning

confidence: 84%

Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor

Defaye

Abdullah

Iftinca

et al. 2022

Cellular and Molecular Gastroenterology and Hepatology

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Chronic abdominal pain is one of the most debilitating symptoms of inflammatory bowel disease. Microgliosis in central pain circuits drives persistent visceral hypersensitivity, but how spinal microglia are activated remains unclear. Adenosine triphosphate released from transient receptor potential vanilloid member 1 þ visceral afferents drives microglial reactivity via P2RY12 in colitis-induced visceral pain.

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Neuroimaging of Visceral Pain

Cited by 6 publications

References 20 publications

Contactless Assessment of Cerebral Autoregulation by Photoplethysmographic Imaging at Green Illumination

Contactless Assessment of Cerebral Autoregulation by Photoplethysmographic Imaging at Green Illumination

Transformer-based classification of visceral pain-related local field potential patterns in the brain

Gut-innervating TRPV1+ Neurons Drive Chronic Visceral Pain via Microglial P2Y12 Receptor

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