Neuroimaging in social anxiety disorder—A meta-analytic review resulting in a new neurofunctional model

Brühl, Annette Beatrix; Delsignore, Aba; Komossa, Katja; Weidt, Steffi

doi:10.1016/j.neubiorev.2014.08.003

Cited by 381 publications

(321 citation statements)

References 183 publications

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“…Moreover, the current finding of exaggerated amygdala response in SAD, as compared to healthy controls, is consistent with the SAD neuroimaging literature (Brühl et al, 2014a). This thesis also adds to the notion that heightened fear-related neural response to selfreferential criticism is an indicator of SAD (Blair et al, 2008a;Blair et al, 2008b).…”

Section: Targeting the Fear Circuitrysupporting

confidence: 89%

“…In general, using a lower statistical threshold we found bilateral amygdala response/volume changes. Furthermore, in accordance with the SAD neuroimaging literature, there is currently no reason to conclude laterality of the amygdala in SAD individuals (Brühl et al, 2014a).…”

Section: Limitationsmentioning

confidence: 86%

“…In the last decade there are at least six reviews including neuroimaging studies on social anxiety (Brühl, Delsignore, Komossa, & Weidt, 2014a;Etkin & Wager, 2007;FreitasFerrari et al, 2010;Hattingh et al, 2012;Miskovic & Schmidt, 2012;Schulz, Mothes-Lasch, & Straube, 2013).…”

Section: The Socially Anxious Brainmentioning

confidence: 99%

“…In the recent meta-analytic review by Brühl et al, (2014a) there is a comprehensive model of SAD based on the neuroimaging literature. Briefly, the SAD model highlights that the bilateral amygdala, the ACC, and the right insula show elevated activity in individuals with SAD relative to healthy controls.…”

Section: The Socially Anxious Brainmentioning

confidence: 99%

“…In general, there is a limited number of studies on structural alterations in SAD compared to healthy individuals, and findings are somewhat inconclusive (Brühl et al, 2014a). Looking beyond the SAD literature there is research suggesting that the grey matter volume of the amygdala is associated with traits of separation anxiety (Redlich et al, 2015), the size of one's social network (Bickart, Wright, Dautoff, Dickerson, & Barrett, 2010), and negative emotional traits (Mincic, 2015).…”

Section: Targeting the Fear Circuitrymentioning

confidence: 99%

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Hjärnan formas av psykologisk behandling

Månsson

2016

Linköping Studies in Behavioural Science

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Restructuring the socially anxious brain -using magnetic resonance imaging to advance our understanding of effective cognitive behaviour therapy for social anxiety disorder Printed by Linköping University Print Services (LiU-Tryck) in Linköping, Sweden, 2016 All previously published papers were reproduced with permission from the publishers ACKNOWLEDGEMENTAvhandlingen har genomförts i ett nära samarbete med forskare vid Uppsala universitet och Umeå Centre for Functional Brain Imaging (UFBI). Forskarskolan i klinisk psykiatri vid Karolinska Institutet tillhandhöll en bra forskarutbildning och PRIMA barn-och vuxenpsykiatri gav mig klinisk erfarenhet.Gerhard Andersson har utmanat och sporrat mig genom hela resan. Förutom färdigheter som forskare så kommer jag minnas när Gerhard gömt mina nycklar, häcklat Björn Afzelius-plattorna och burit iväg min cykel och annonserat att den "bortskänkes". Men Gerhards hyss överträffar knappats det brev som jag skickade med internposten för ett par år sedan. Tomas Furmark är en viktig del på min utvecklingskurva som forskare och när ni hör mig säga att "det finns ett par stenar till att vända på" eller att "man skulle ju vilja veta…" så förstår ni nu var det kommer från. Tomas är en av mina förebilder som forskare, men vi har också haft väldigt rolig under konferenserna och karaokekvällarna. C-J Boraxbekk fångade tidigt upp mitt intresse för forskning och det är tack vare C-Js inbjudan som jag fick möjligheten att pyssla med hjärnavbildningsforskning. Per Carlbring kom till Umeå som en vind och tog psykologstudenter med storm. Det hade inte blivit en randomiserad klinisk prövning utan Per. Jag har haft turen att få lära mig av fyra duktiga forskare från olika forskningskulturer och arbetssätt. Denna erfarenhet kommer forma mig som vetenskapsman. Jag har nu flera rollmodeller vars hantverk jag fått se på nära håll. Inte minst har jag haft väldigt kul. Från botten av mitt hjärta -tack Gerhard, Tomas, C-J och Per! Jag har haft ett stort nätverk av kollegor och kompisar som varit betydelsefulla och som jag vill berätta mer om. Andre F Marquand, Steven C R Williams, Alireza Salami, Owe Bodlund, Malin Gren Landell och Carl-Johan Uckelstam bidrog med klinisk kompetens och stöd vid analysarbete. I Umeå hade jag ett stort gäng studenter som hjälpte till vid experimenten, ingen nämnd ingen glömd. Blivande hjärnforskaren Hugo Hesser är inte bara en kul gubbe och en engagerad lärare som jag beundrar han tackade även ja till att vara granskare på mitt slutseminarium. Delar av mina arbeten granskades vid halvtid av Håkan Fischer, en hyvens person som också introducerat mig till ett gäng hyggliga sömnforskare. Helen MacDonald, a dear friend and a fellow EABCT board member, helped me with proof reading. Det var med alla dessa personers hjälp som jag kunde sätta pricken över i:et! Många har bidragit med kunskap genom att jag tagit del av deras forskning, lyssnat på deras presentationer eller att vi diskuterat kniviga frågor. Här vill jag passa på att tacka ett urval av dessa inspiratörer. För e...

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Section: Targeting the Fear Circuitrysupporting

confidence: 89%

Section: Limitationsmentioning

confidence: 86%

Section: The Socially Anxious Brainmentioning

confidence: 99%

Section: The Socially Anxious Brainmentioning

confidence: 99%

Section: Targeting the Fear Circuitrymentioning

confidence: 99%

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Hjärnan formas av psykologisk behandling

Månsson

2016

Linköping Studies in Behavioural Science

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Amygdala-Cortical Connectivity: Associations with Anxiety, Development, and Threat

et al. 2016

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Background Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al., 2013). However, translational research suggests that amygdala-PFC circuitry mediates responses following learned extinction. Anxiety-related perturbations may emerge in functional connectivity within this circuit during extinction recall tasks. The current report uses data from the prior study to examine how anxiety and development relate to task-dependent amygdala-PFC connectivity. Methods Eighty-two subjects (14 anxious youths, 15 anxious adults, 25 healthy youths, 28 healthy adults) completed an extinction recall task, which directed attention to different aspects of stimuli. Generalized psychophysiological interaction analysis tested whether task-dependent functional connectivity with anatomically-defined amygdala seed regions differed across anxiety and age groups. Results Whole-brain analyses showed significant interactions of anxiety, age, and attention task (i.e., threat appraisal, explicit threat memory, physical discrimination) on left amygdala functional connectivity with the vmPFC and ventral anterior cingulate cortex (Talairach XYZ coordinates: −16, 31, −6 and 1, 36, −4). During threat appraisal and explicit threat memory (vs. physical discrimination), anxious youth showed more negative amygdala-PFC coupling, whereas anxious adults showed more positive coupling. Conclusions In the context of extinction recall, anxious youths and adults manifested opposite directions of amygdala-vmPFC coupling, specifically when appraising and explicitly remembering previously learned threat. Future research on anxiety should consider associations of both development and attention to threat with functional connectivity perturbations.

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Social anxiety is associated with BNST response to unpredictability

et al. 2019

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Background: Anxiety disorders are highly prevalent and cause substantial suffering and impairment. Whereas the amygdala has well-established contributions to anxiety, evidence from rodent and nonhuman primate models suggests that the bed nucleus of the stria terminalis (BNST) may play a critical, and possibly distinct, role in human anxiety disorders. The BNST mediates hypervigilance and anticipatory anxiety in response to an unpredictable or ambiguous threat, core symptoms of social anxiety, yet little is known about the BNST's role in social anxiety.Methods: Functional magnetic resonance imaging was used to measure neural responses during a cued anticipation task with an unpredictable, predictable threat, and predictable neutral cues followed by threat or neutral images. Social anxiety was examined using a dimensional approach (N = 44 adults).Results: For unpredictable cues, higher social anxiety was associated with lower BNST-amygdala connectivity. For unpredictable images, higher social anxiety was associated with greater connectivity between the BNST and both the ventromedial prefrontal cortex and the posterior cingulate cortex and lower connectivity between the BNST and postcentral gyrus. Social anxiety moderated the BNST-amygdala dissociation for unpredictable images; higher social anxiety was associated with BNST > amygdala response to unpredictable threat relative to unpredictable neutral images.Conclusions: Social anxiety was associated with alterations in BNST responses to unpredictability, particularly in the BNST's interactions with other brain regions, including the amygdala and prefrontal cortex. To our knowledge, these findings provide the first evidence for the BNST's role in social anxiety, which may be a potential new target for prevention and intervention.

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Neuroimaging in social anxiety disorder—A meta-analytic review resulting in a new neurofunctional model

Cited by 381 publications

References 183 publications

Hjärnan formas av psykologisk behandling

Hjärnan formas av psykologisk behandling

Amygdala-Cortical Connectivity: Associations with Anxiety, Development, and Threat

Social anxiety is associated with BNST response to unpredictability

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