Neuroimaging in Psychiatric Disorders: A Bibliometric Analysis of the 100 Most Highly Cited Articles

Gong, Bo; Sattar, Naveed; Hafeez, Dawood M.; Afzal, Khalid I.; Majeed, Salman; Abele, Jonathan; Nicolaou, Savvas; Khosa, Faisal

doi:10.1111/jon.12570

Cited by 36 publications

(20 citation statements)

References 59 publications

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“…The brain regions revealed in this study are known to be involved in TRD [7,20]. The insula is particularly involved in emotional identification and in the affective state in response to a stimulus.…”

Section: Discussionmentioning

confidence: 65%

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Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

et al. 2020

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Background Brain SPECT perfusion and PET metabolism have been, most often interchangeably, proposed to study the underlying pathological process in major depressive disorder (MDD). The objective of this study was to specify similarities and inconsistencies between these two biomarkers according to global characteristics of the disease. We conducted a retrospective study in 16 patients suffering from treatment-resistant MDD who underwent, during the same current episode, a cerebral perfusion SPECT with 99mTc-HMPAO and a metabolic PET with 18F-FDG. Whole-brain voxel-based SPM(T) maps were generated in correlation with the number of depressive episodes and in correlation with the depression duration, separately for the two exams (p-voxel < 0.001 uncorrected, k > 20). Results No significant correlations were found between brain metabolism and either the number of depressive episodes or the duration of the disease, even at an uncorrected p-voxel < 0.005. On the other hand, the increased number of depressive episodes was correlated with decreased perfusion of the right middle frontal cortex, the right anterior cingulum cortex, the right insula, the right medial temporal cortex and the left precuneus. The increased depression duration was correlated with decreased perfusion of the right anterior cingulum cortex. Conclusions This preliminary study demonstrates more significant results with brain perfusion compared with glucose metabolism in treatment-resistant MDD, highlighting the value of brain SPECT despite less favourable instrumentation detection compared to PET.

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Section: Discussionmentioning

confidence: 65%

“…PET is one of the main neuroimaging techniques evaluated in recent psychiatry research [20]. Indeed, PET is usually preferred to SPECT because of better spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

et al. 2020

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“…14 The same disparity is observed in the field of brain imaging. A recent bibliometric review found that among the 100 most highly cited neuroimaging studies in psychiatric disorders, only six had a LMIC researcher as first author 16 (China in all cases). In Brazil, only one large neuroimaging study designed to assess various outcomes in terms of psychopathology with published data on youth depression is available.…”

Section: Introductionmentioning

confidence: 99%

Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results

Battel

Swartz

Anés

et al. 2020

Braz. J. Psychiatry

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Objective: To test the feasibility and to present preliminary results of a neuroimaging protocol to evaluate adolescent depression in a middle-income setting. Methods: We assessed psychotropic medication-free adolescents (age range 14-16 years) with a diagnosis of major depressive disorder (MDD). Participants underwent a comprehensive clinical evaluation and both structural and functional magnetic resonance imaging (fMRI). In this pilot study, a preliminary single-group analysis of resting-state fMRI (rs-fMRI) data was performed, with a focus on the default mode network (DMN), cognitive control network (CCN), and salience network (SN). Results: The sample included 29 adolescents with MDD (mean age 16.01, SD 0.78) who completed the protocol. Only two participants were excluded due to MRI quality issues (head movement), and were not included in the analyses. The scans showed significant connectivity between the medial prefrontal cortex and posterior cingulate cortex (DMN), the ACC and anterior insula (SN), and the lateral prefrontal cortex and dorsal parietal cortex (CCN). Conclusion: We demonstrated the feasibility of implementing a complex neuroimaging protocol in a middle-income country. Further, our preliminary rs-fMRI data revealed patterns of resting-state connectivity consistent with prior research performed in adolescents from high-income countries.How to cite this article: Battel L, Swartz J, Anes M, Manfro PH, Rohde LA, Viduani A, et al. Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results. Braz J Psychiatry. 2020;42:6-13. http://dx.

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“…The brain regions revealed in this study are known to be involved in TRD 7,20 . The insula is particularly involved in emotional identi cation and in the affective state in response to a stimulus.…”

Section: Discussionmentioning

confidence: 70%

Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

Tastevin

Boyer

Korchia

et al. 2020

Preprint

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Background: Brain SPECT perfusion and PET metabolism have been, most often interchangeably, proposed to study the underlying pathological process in major depressive disorder (MDD). The objective of this study was to specify similarities and inconsistencies between these two biomarkers according to global characteristics of the disease. We conducted a retrospective study in 16 patients suffering from treatment-resistant MDD who underwent, during the same current episode, a cerebral perfusion SPECT with 99mTc-HMPAO and a metabolic PET with 18F-FDG. Whole-brain voxel-based SPM(T) maps were generated in correlation with the number of depressive episodes and in correlation with the depression duration, separately for the two exams (p-voxel<0.001 uncorrected, k>20). Results: No significant correlations were found between brain metabolism and either the number of depressive episodes or the duration of the disease, even at an uncorrected p-voxel<0.005. On the other hand, the increased number of depressive episodes was correlated with decreased perfusion of the right middle frontal cortex, the right anterior cingulum cortex, the right insula, the right medial temporal cortex and the left precuneus. The increased depression duration was correlated with decreased perfusion of the right anterior cingulum cortex. Conclusions: This preliminary study demonstrates more significant results with brain perfusion compared with glucose metabolism in treatment-resistant MDD, highlighting the value of brain SPECT despite less favourable instrumentation detection compared to PET.

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Neuroimaging in Psychiatric Disorders: A Bibliometric Analysis of the 100 Most Highly Cited Articles

Cited by 36 publications

References 59 publications

Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

Neuroimaging adolescents with depression in a middle-income country: feasibility of an fMRI protocol and preliminary results

Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

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