Neuroimaging in pediatric temporal lobe epilepsy: Does neuroimaging accurately predict pathology and surgical outcome?

Kassiri, J; Elliott, Cameron; Liu, Natarie; Mailo, Janette; Rajapakse, Thilinie; Schmitt, Laura; Wheatley, Matthew; Sinclair, D. Barry

doi:10.1016/j.eplepsyres.2021.106680

Cited by 1 publication

(1 citation statement)

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“…There were several exciting studies published in this very recent time period addressing determinants predicting the outcome of surgical therapy with the intention-to-cure epilepsy. These parameters covered the underlying etiology as confirmed by histopathology diagnosis [2 ▪▪ ,4,5], the extent or approach of surgical resections [6,7 ▪ ], as well as neurophysiology or neuroimaging findings obtained during the presurgical evaluation [8 ▪ ,9,10]. Notwithstanding, the latter have a profound impact for clinical patient management as they directly inform the decision-making process for or against surgical therapy.…”

Section: Outcome Prediction For Epilepsy Surgery In Cohort Studies Pu...mentioning

confidence: 99%

Neuropathology and epilepsy surgery

Hoffmann

Blümcke

2022

Current Opinion in Neurology

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Purpose of reviewNeurosurgical treatment of patients suffering from drug-resistant focal epilepsy is recognized as a successful, yet underutilized medical treatment option. By searching PubMed for articles published between January 2020 and September 2021 with the broad search terms 'neuropathology' AND 'epilepsy surgery', this review highlights the active field of etiology-based epilepsy research in human tissue. Recent findingsAll papers addressing the most common epileptogenic human brain disease entities, i.e. focal cortical dysplasia (FCD), brain tumors or hippocampal sclerosis, and written in English language were eligible for our review. We can conclude from this review that etiology-based studies are of foremost interest for (1) the development of prediction models for postsurgical seizure outcome; (2) decipher genetic and molecular alterations to better define disease entities and underlying molecular pathomechanisms, and (3) the translation of human tissue-derived biomarker into clinically useful diagnostics or novel therapeutic targets in the near future.

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Section: Outcome Prediction For Epilepsy Surgery In Cohort Studies Pu...mentioning

confidence: 99%