Neuroimaging in Attention-Deficit/Hyperactivity Disorder: Recent Advances

Firouzabadi, Fatemeh Dehghani; Ramezanpour, Sara; Firouzabadi, Mohammad Dehghani; Yousem, Ilyssa J; Puts, Nicolaas A.J.; Yousem, David M.

doi:10.2214/ajr.21.26316

Cited by 25 publications

(19 citation statements)

References 85 publications

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“…The observed effects on attention, hyperactivity, and impulsivity may be explained by prefrontal cortex dysfunctioning and associated altered inhibitory control, which characterizes patients with ADHD [ 46 ]. However, research on brain functioning or inhibitory control of individuals with IWH is currently lacking.…”

Section: Discussionmentioning

confidence: 99%

Inattention, Impulsivity, and Hyperactivity among Individuals with Self-Reported Impaired Wound Healing

et al. 2022

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Background: Inattention and impulsivity are common causes of accidents and injury. The aim of the current study was to examine the level of attention deficit (AD), hyperactivity, and impulsivity (HI) in individuals with and without self-reported impaired wound healing (IWH). Methods: A survey was conducted among N = 773 Dutch young adults, 18–30 years old. N = 198 were allocated to the IWH group and N = 575 to the control group. All participants completed the Attention Deficit Hyperactivity Disorder (ADHD) Rating Scale. Results: The analysis revealed that the IWH group has significantly higher scores on AD and HI, compared to the control group. Among the IWH group, 12.8% screened positive for AD (compared to 5.8% of the control group) and 14.0% screened positive for HI (compared to 7.4% of the control group). Conclusion: Clinically relevant increased inattention, impulsivity, and hyperactivity were observed among individuals with self-reported impaired wound healing.

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Section: Discussionmentioning

confidence: 99%

Inattention, Impulsivity, and Hyperactivity among Individuals with Self-Reported Impaired Wound Healing

et al. 2022

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“…The static amplitude of low-frequency fluctuation (sALFF) is one of the commonly used data analysis methods for fMRI, it is a reliable and sensitive technique [23]. sALFF is thought to reflect the strength of local neuronal activity [24] and has demonstrated good-to-moderate test-retest reliability [25]. sALFF has already been used in many studies on diseases, including chronic pain and Alzheimer's disease [15,18,26].…”

Section: Introductionmentioning

confidence: 99%

Amplitude of low-frequency fluctuation after a single-trigger pain in patients with classical trigeminal neuralgia

Wang

Pan

et al. 2022

J Headache Pain

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Objective This study aimed to explore the central mechanism of classical trigeminal neuralgia (CTN) by analyzing the static amplitude of low-frequency fluctuation (sALFF) and dynamic amplitude of low-frequency fluctuation (dALFF) in patients with CTN before and after a single-trigger pain. Methods This study included 48 patients (37 women and 11 men, age 55.65 ± 11.41 years) with CTN. All participants underwent 3D-T1WI and three times resting-state functional magnetic resonance imaging. The images were taken before stimulating the trigger zone (baseline), within 5 s after stimulating the trigger zone (triggering-5 s), and in the 30th minute after stimulating the trigger zone (triggering-30 min). The differences between the three measurements were analyzed using a repeated-measures analysis of variance. Results The sALFF values of the bilateral middle occipital gyrus and right cuneus gradually increased, and the values of the left posterior cingulum gyrus and bilateral superior frontal gyrus gradually decreased in triggering-5 s and triggering-30 min. The values of the right middle temporal gyrus and right thalamus decreased in triggering-5 s and subsequently increased in triggering-30 min. The sALFF values of the left superior temporal gyrus increased in triggering-5 s and then decreased in triggering-30 min. The dALFF values of the right fusiform gyrus, bilateral lingual gyrus, left middle temporal gyrus, and right cuneus gyrus gradually increased in both triggering-5 s and triggering-30 min. Conclusions The sALFF and dALFF values changed differently in multiple brain regions in triggering-5 s and triggering-30 min of CTN patients after a single trigger of pain, and dALFF is complementary to sALFF. The results might help explore the therapeutic targets for relieving pain and improving the quality of life of patients with CTN.

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“…However, we should note that the sample size included for CBT-image analyses is small, and the results should be interpreted with caution and need to be validated. In addition to functional impairments, significant alteration in multiple structural indices of precuneus and PCC has been indicated in prior findings of both children and adults with ADHD, including decreased volume, cortical thickness and surface area (Firouzabadi et al, 2021). It is also worthy of further exploration to elucidate whether and how these structural and functional abnormalities in DMN regions jointly participated in the pathogenesis of ADHD.…”

Section: Discussionmentioning

confidence: 93%

Connectome-wide association analysis identified significant brain functional alteration in adults with attention-deficit/hyperactivity disorder

Liu

Chen

Huang

et al. 2021

Preprint

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Adults with attention-deficit/hyperactivity disorder (ADHD), as an extreme-phenotype of ADHD, is still facing problems of inconsistency and undeciphered mechanisms for its neuropathology. To address this matter, our present study performed connecotome-wide voxel-based analyses with the resting-state fMRI data of 84 adults with ADHD and 89 healthy controls. We found that functional connectivity patterns of the left precuneus and the left middle temporal significantly altered in ADHD populations serving as potential neural biomarkers to distinguish ADHD with healthy controls, with subsequent seed-based analysis revealing the dysfunction of functional connections both intra- and inter- default mode and attention networks, among which middle temporal gyrus plays the key role of bridge linking the default mode and attention networks. After cognitive behavioral therapy, two of these ADHD-altered functional connections ameliorated accompanied with improvement of ADHD core symptoms. Additionally, imaging genetic analyses also revealed close relationships between the observed brain functional alterations and ADHD-risk genes. Taken together, our findings suggested the interference of default mode on attention networks in adults with ADHD, which would be severing as a potential biomarker for both ADHD pathogenesis and treatment effects.

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Neuroimaging in Attention-Deficit/Hyperactivity Disorder: Recent Advances

Cited by 25 publications

References 85 publications

Inattention, Impulsivity, and Hyperactivity among Individuals with Self-Reported Impaired Wound Healing

Inattention, Impulsivity, and Hyperactivity among Individuals with Self-Reported Impaired Wound Healing

Amplitude of low-frequency fluctuation after a single-trigger pain in patients with classical trigeminal neuralgia

Connectome-wide association analysis identified significant brain functional alteration in adults with attention-deficit/hyperactivity disorder

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