Neuroimaging in anxiety disorders

Engel, Kirsten; Bandelow, Borwin; Gruber, Oliver; Wedekind, Dirk

doi:10.1007/s00702-008-0077-9

Cited by 96 publications

(83 citation statements)

References 141 publications

(127 reference statements)

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“…In view of the research evidence highlighted above, one might argue that as anxiety is a potentially treatable condition [69,[136][137][138][139], intervention may prove am important factor in the management of individuals living with cognitive impairment and dementia [2,62,75], with dissemination of information regarding late-life anxiety disorder vital as evidence-based treatments, pharmacological and psychotherapy, are available [43, [131][132][133][134][135][136][137][138][139][140][141]. There are however important caveats to consider.…”

Section: Discussionmentioning

confidence: 99%

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Anxiety in old age and dementia - implications for clinical and research practice

Tales¹,

Basoudan²

2016

Neuropsychiatry (London)

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While extensive research has been performed in relation to anxiety in general, there is a marked paucity of investigation on older adulthood, especially in relation to those individuals living with mild cognitive impairment (MCI) and dementia, with the majority of such studies clinically based and focusing upon 'formal' anxiety disorders. It is however becoming increasingly evident that the detrimental effects of anxiety are not limited to clinical anxiety disorders but can instead occur in response to anxiety per se, i.e., sub-syndromal anxiety including various levels of trait and state anxiety. Furthermore, it is increasingly apparent that even non-clinical anxiety can influence many more components of information processing than previously recognized.

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Section: Discussionmentioning

confidence: 99%

“…Closely associated with attention-related processing is balance. The finding that state and trait anxiety can affect sensory inputs involved in balance [103,[132][133][134] …”

Section: Anxiety and Attention-related Processingmentioning

confidence: 99%

Anxiety in old age and dementia - implications for clinical and research practice

Tales¹,

Basoudan²

2016

Neuropsychiatry (London)

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“…Además de la AMG otras regiones del sistema límbico como el hipocampo (HPC) y la corteza prefrontal (CPF) han demostrado jugar un rol significativo en situaciones de miedo y ansiedad (Akirav & Maroun, 2007;Engel, Bandelow, Gruber, & Wedekind, 2009;Moustafa et al, 2013). El HPC parece estar directamente involucrado en la generación de una respuesta ante la situación adversa, principalmente en el conflicto de pelea-huida ("fightflight").…”

Section: Regiones Cerebrales Involucradas En El Miedo Y La Ansiedadunclassified

“…En la resolución de este conflicto, la corteza cingulada anterior (ACC) va a reducir la actividad de la amígdala, permitiendo mayor actividad de la CPF (Engel et al, 2009). Como parte de la respuesta a una amenaza, la AMG también favorece el aumento de las concentraciones de glucocorticoides, que a su vez estimulan la actividad de la amígdala e inhiben el funcionamiento de la CPF.…”

Section: Regiones Cerebrales Involucradas En El Miedo Y La Ansiedadunclassified

Modelos animales de miedo y ansiedad: descripciones neuro-conductuales

Gallegos

Castillo

2014

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Modelos animales de miedo y ansiedad: descripciones neuro-conductualesResumen. Los modelos animales de miedo y ansiedad se han utilizado para la comprensión de trastornos de ansiedad en humanos, sin embargo no ha sido fácil diferenciar ambos conceptos a nivel fisiológico y conductual. Una forma de modelar estos trastornos es mediante pruebas conductuales de ansiedad (como el laberinto en cruz elevado o la prueba de campo abierto) y de miedo (como el condicionamiento al miedo y la evitación activa). Además, estos modelos permiten estudiar diferentes áreas cerebrales involucradas como la amígdala, el hipocampo y la corteza prefrontal. En general, el miedo y la ansiedad se pueden considerar respuestas adaptativas normales, sin embargo niveles elevados de ambos pueden generar consecuencias perjudiciales para el individuo. Palabras clave. Modelos animales, ansiedad, miedo, comportamiento.Abstract. Animal models of fear and anxiety have been widely used for the comprehension of anxiety disorders in humans, however, it has not been easy to distinguish between both concepts at physiological and behavioral levels. One way to model anxiety disorders is through behavioral tests of anxiety, (such as the elevated plus maze and the open field test), and fear (using the fear conditioning paradigm and active avoidance). Furthermore, animal models are relevant to study the involvement of different brain areas, like the amygdala, hippocampus and prefrontal cortex. In general, fear and anxiety can be considered as normal adaptive responses; however, elevated levels of both might generate detrimental consequences for the individual.

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“…In those with general anxiety disorder, these connections functionally seem to be less distinct, with greater gray matter in the central nucleus. Another difference is that the amygdala areas have decreased connectivity with the insula and cingulate areas that control general stimulus salience while having greater connectivity with the parietal cortex and PFC circuits that underlie executive functions [46,47]. More recently, functional brain imaging studies have been particularly useful in delineating the neurocircuitry of the anxiety disorders.…”

Section: Neural Circuits Involved In Anxietymentioning

confidence: 99%

A Review on the Neural Circuits in Anxiety Disorders

Arya

Sindhwani²

2016

Asian J Pharm Clin Res

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Anxiety disorders are among the most common mental, emotional, and behavioral problems. These affect one-eighth of the total population worldwide. Anxiety disorders are a group of mental disorders characterized by irritability, fear, insomnia, nervousness, tachycardia, inability to concentrate, poor coping skills, palpitation, sweating, agoraphobia, and social withdrawal. Brain regions and networks involved in anxiety symptomatology is an effort to better understand the mechanism involved and to develop more effective treatments for the anxiety disorders. Thus, neuroanatomical and neuroimaging research in anxiety disorders has centered on the role of the amygdala, reciprocal connections between the amygdala and the prefrontal cortex, and, most recently, alterations in interoceptive processing by the anterior insula. Anxiety disorders are characterized by alterations in a diverse range of neurochemical systems, suggesting ample novel targets for drug therapies. The neurotransmitter like corticotropin-releasing factor, neuropeptides (substance P, neuropeptide Y, oxytocin, orexin, and galanin) are implicated in anxiety pathways. Each of these active areas of research holds promise for expanding and improving evidence-based treatment options for individuals suffering with clinical anxiety. Therefore, this article gives the information on the neurocognitive mechanisms, causes, neurotransmitter involved in anxiety disorders and emphasize on the therapeutic targets for anxiety disorders.

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Neuroimaging in anxiety disorders

Cited by 96 publications

References 141 publications

Anxiety in old age and dementia - implications for clinical and research practice

Anxiety in old age and dementia - implications for clinical and research practice

Modelos animales de miedo y ansiedad: descripciones neuro-conductuales

A Review on the Neural Circuits in Anxiety Disorders

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