Neuroimaging genomic studies in major depressive disorder: A systematic review

Zhang, Huifeng; Mellor, David; Peng, Daihui

doi:10.1111/cns.12829

Cited by 13 publications

(9 citation statements)

References 124 publications

(307 reference statements)

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“…A number of genetic-related factors, genomic regions, polymorphisms, and other related aspects have been examined with respect to depression [ 61 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 ,...…”

Section: Resultsmentioning

confidence: 99%

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

2021

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Depression is one of the leading causes of disability, and, if left unmanaged, it can increase the risk for suicide. The evidence base on the determinants of depression is fragmented, which makes the interpretation of the results across studies difficult. The objective of this study is to conduct a thorough synthesis of the literature assessing the biological, psychological, and social determinants of depression in order to piece together the puzzle of the key factors that are related to this condition. Titles and abstracts published between 2017 and 2020 were identified in PubMed, as well as Medline, Scopus, and PsycInfo. Key words relating to biological, social, and psychological determinants as well as depression were applied to the databases, and the screening and data charting of the documents took place. We included 470 documents in this literature review. The findings showed that there are a plethora of risk and protective factors (relating to biological, psychological, and social determinants) that are related to depression; these determinants are interlinked and influence depression outcomes through a web of causation. In this paper, we describe and present the vast, fragmented, and complex literature related to this topic. This review may be used to guide practice, public health efforts, policy, and research related to mental health and, specifically, depression.

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Section: Resultsmentioning

confidence: 99%

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

2021

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“…Depression is a major public health problem linked with decreased functionality and may result in mortality [ 43 ]. The pathophysiology of depression is linked with increased activity in hypothalamic-pituitary-adrenal axis, hypo-connectivity in frontoparietal network, structural changes in brain, alterations in neural and glial cells, abnormal brain activity and neurotransmitter functions (involving GABA, glutamate, serotonin, epinephrine and norepinephrine) [ 44 , 45 ].…”

Section: Psychiatric Disorders and Extracellular Vesiclesmentioning

confidence: 99%

Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria

Ilgın

Topuzoğlu

2018

Psychiatry Investig

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The analysis of extracellular vesicles has been accelerated because of the technological advancements in omics methods in recent decades. Extracellular vesicles provide multifaceted information regarding the functional status of the cells. This information would be critical in case of central nervous system cells, which are confined in a relatively sealed biological compartment. This obstacle is more dramatic in psychiatric disorders since their diagnosis primarily depend on the symptoms and signs of the patients. In this paper, we reviewed this rapidly advancing field by discussing definition of extracellular vesicles, their biogenesis and potential use as clinical biomarkers. Then we focused on their potential use in psychiatric disorders in the context of diagnosis and treatment of these disorders. Finally, we tried to combine the RDoC (Research Domain Criteria) with the use of extracellular vesicles in psychiatry research and practice. This review may offer new insights in both basic and translational research focusing on psychiatric disorders.

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“…However, the results were inconsistent with some previous studies. For example, a meta-analysis study including only European Caucasian populations did not find that MTHFR C677T polymorphism was associated with recurrent depression ( 13 ), and there was a study suggesting that the C677T genotype may be a protector for MDD ( 14 ), yet most evidence from meta-analyses strongly suggested that the T allele or TT genotype tends to be a risk effect to MDD ( 5 , 15 ). The inconsistent results may be due to clinical heterogeneity, ethnicity, geography, age, size of the sample, medication confounding factors, lack of statistical efficiencies, and/or the interaction of MTHFR C677T with other genes.…”

Section: Introductionmentioning

confidence: 99%

“…The inconsistent results may be due to clinical heterogeneity, ethnicity, geography, age, size of the sample, medication confounding factors, lack of statistical efficiencies, and/or the interaction of MTHFR C677T with other genes. Gene × gene studies deduced that by affecting the methyl donor SAM, MTHFR C677T exhibited a coordinated effect with some genes which may be involved in the monoamine neurotransmitter, dopaminergic pathway, and regulation of neuroplasticity, via diminished methyl ( 15 ). For instance, 5-HTT can remove 5-HT from the synaptic cleft, which in turn determines the amount and duration of postsynaptic membrane receptor-mediated signaling.…”

Section: Introductionmentioning

confidence: 99%

Roles of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphisms in First-Episode, Drug-Naive Adult Patients With Depression

et al. 2020

Front. Psychiatry

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5,10-Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is considered as a predisposition and promising genetic candidate to major depressive disorder (MDD), as it is associated with impaired one-carbon cycles, which may be involved in the pathogenesis of depression. Cortical thickness (CT) and subcortical structure volumes have been extensively studied in MDD and have been proposed as one of the phenotypes for MDD. We intend to discuss the association between CT, subcortical structure volume, and MTHFR C677T polymorphism in first-episode, treatment-naive patients with MDD. In this study, 127 adult patients with MDD and 101 age- and gender-matched healthy controls (HCs) were included. All subjects underwent T1-weighted MRI, MTHFR C677T genotyping, and FreeSurfer software-based morphological analysis. MDD patients have been detected to have significantly decreased volumes in the left nucleus accumbens (P < 0.001). The MTHFR 677 T allele carriers manifested with thinner CT in the left caudal anterior cingulate cortex (cACC, P = 0.009) compared with CC genotype. There were significant genotype-by-diagnosis interactions for the CT in the left cACC (P = 0.009), isthmus cingulate (P = 0.002), medial orbitofrontal lobe (P = 0.012), posterior cingulate (P = 0.030), and the right lateral orbitofrontal lobe (P = 0.012). We also found a trend in the interaction effect on the volume of the left putamen (P = 0.050). Our results revealed that MTHFR C677T polymorphism may be involved in the dysfunction of limbic–cortical–striatal–pallidal–thalamic (LCSPT) circuits mediating emotion processing, which may contribute to pathogenesis of MDD.

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Neuroimaging genomic studies in major depressive disorder: A systematic review

Cited by 13 publications

References 124 publications

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature

Extracellular Vesicles in Psychiatry Research in the Context of RDoC Criteria

Roles of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphisms in First-Episode, Drug-Naive Adult Patients With Depression

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