Neuroimaging Findings Related to Behavioral Disturbances in Alzheimer's Disease: A Systematic Review

Alves, Gilberto Sousa; Carvalho, André F.; Carvalho, Luiza de Amorim de; Sudo, Felipe Kenji; Siqueira-Neto, José Ibiapina; Oertel-Knöchel, Viola; Jurcoane, Alina; Knöchel, Christian; Boecker, Henning; Laks, Jérson; Pantel, Johannes

doi:10.2174/1567205013666160603010203

Cited by 36 publications

(26 citation statements)

References 83 publications

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“…Apathy is the most widely researched NPS, and it has been often linked to frontal lobe (Alves et al, 2017) and anterior cingulate cortex hypoperfusion and structural abnormalities (Rosenberg et al, 2015). With diminished motivation being a core feature of the concept (Robert et al, 2009), our findings of associations between apathy and both ADL domains are not surprising.…”

Section: Discussionmentioning

confidence: 53%

Neuropsychiatric symptoms and activities of daily living in Alzheimer’s disease: ALSOVA 5-year follow-up study

Saari

Hallikainen

Hintsa

et al. 2019

Int. Psychogeriatr.

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ABSTRACTBackground:Neuropsychiatric symptoms (NPSs) in Alzheimer’s disease (AD) are related to activities of daily living (ADLs), but longitudinal studies are sparse.Objectives:We investigated which NPSs were related to decline in instrumental ADLs (IADLs) and basic ADLs (BADLs) in a 5-year follow-up of individuals with AD.Methods:ALSOVA 5-year follow-up study data of 236 individuals with very mild or mild AD at baseline and their caregiver were analyzed. IADLs and BADLs were assessed with Alzheimer’s Disease Cooperative Study ADL inventory, and NPSs with Neuropsychiatric Inventory at annual follow-up visits. Generalized estimating equations (GEEs) were used for longitudinal data analysis, and NPS–ADL networks were estimated to demonstrate symptom interactions.Results:Apathy [rate ratio (RR) 1.23, 95% CI 1.06–1.44, p = 0.007], aberrant motor behavior (RR 1.24, 95% CI 1.07–1.44, p = 0.005), and appetite disturbances (RR 1.22, 95% CI 1.06–1.41, p = 0.005) were related to impairment in BADLs, and the same symptoms (RR 1.13, 95% CI 1.07–1.21, p < 0.001; RR 1.13, 95% CI 1.07–1.20, p < 0.001; RR 1.14; 95% CI 1.08–1.21, p < 0.001, for apathy, aberrant motor behavior, and appetite disturbances, respectively), in addition to delusions (RR 1.09, 95% CI 1.03–1.15, p = 0.004), were related to IADL impairment. Symptom networks varied at different time points.Conclusion:As AD progresses, common (apathy) and uncommon NPSs (aberrant motor behavior, appetite disturbances, delusions) seem to be related to ADLs through various symptom interactions. Previous literature suggests that frontal pathology could underlie these relationships.

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Section: Discussionmentioning

confidence: 53%

Neuropsychiatric symptoms and activities of daily living in Alzheimer’s disease: ALSOVA 5-year follow-up study

Saari

Hallikainen

Hintsa

et al. 2019

Int. Psychogeriatr.

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“…First, memory function has been demonstrated to be related to the anterior cingulate [15]. The anterior cingulate may be involved in the presentation of some BPSD [16]. Our results suggested that memory was correlated with the BPSD.…”

Section: Discussionmentioning

confidence: 62%

Risk Factors of Behavioral and Psychological Symptoms in Patients with Alzheimer Disease: The Clinical Research of Dementia of South Korea Study

et al. 2019

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BackgroundFew studies have evaluated risk factors for behavioral and psychological symptoms of dementia at the initial assessment for Alzheimer disease in large patient samples. In this study, the factors influencing Alzheimer disease were examined using the Clinical Research of Dementia of South Korea data.MethodsThis cross-sectional study was conducted using data of 1,128 patients with Alzheimer disease. The behavioral and psychological symptoms of dementia were examined using the Korean version of the Neuropsychiatric Inventory. Demographic characteristics, health-related behavior, neuropsychological tests, comorbidities, blood test results, and caregiver characteristics were assessed. Median logistic regression analysis with adjustment for covariates was conducted.ResultsThe behavioral and psychological symptoms of dementia were negatively associated with memory (P=0.022) and frontal/executive (P<0.001) function in the Seoul Neuropsychological Screening Battery-dementia, Barthel Index for Activities of Daily Living (P<0.001), Korean version of the Mini-Mental State Examination score (P=0.003), and caregiver age (P=0.005) after adjustment for confounding factors, and positively associated with the Seoul-Instrumental Activities of Daily Living score (P<0.001), Clinical Dementia Rating Sum of Box (P<0.001), Global Deterioration Scale score (P<0.001), abnormality of free T4 level (P<0.001), anemia (P<0.001), and family history of stroke (P=0.001). Patients with female caregivers exhibited more severe behavioral and psychological symptoms of dementia than those with male caregivers.ConclusionBehavioral and psychological symptoms of dementia in Alzheimer disease patients were associated with various risk factors including the inability to live independently and Alzheimer disease severity. These findings suggest that prevention and treatment strategies for the behavioral and psychological symptoms of dementia should be comprehensive.

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“…Huge neuroscientific projects are therefore being conducted in the U.S. [ 2 ], Europe [ 3 ], and other countries, where structural and functional neuroimaging techniques are widely used to reveal physiological functions of the central nervous system. The brain-behavior relationship has thus been gradually delineated for a wide range of mental illnesses, including neurological disorders (e.g., Alzheimer's disease [ 4 ] and Parkinson's disease [ 5 ]), psychiatric disorders (e.g., depressive disorder [ 6 ] and schizophrenia [ 7 ]) and developmental disorders (e.g., autism spectrum disorder [ 8 ]). Most of these studies have compared the brain structures or functions of patients with specific diagnoses with “healthy” participants.…”

Section: Introductionmentioning

confidence: 99%

MRI-based Brain Healthcare Quotients: A bridge between neural and behavioral analyses for keeping the brain healthy

et al. 2017

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Neurological and psychiatric disorders are a burden on social and economic resources. Therefore, maintaining brain health and preventing these disorders are important. While the physiological functions of the brain are well studied, few studies have focused on keeping the brain healthy from a neuroscientific viewpoint. We propose a magnetic resonance imaging (MRI)-based quotient for monitoring brain health, the Brain Healthcare Quotient (BHQ), which is based on the volume of gray matter (GM) and the fractional anisotropy (FA) of white matter (WM). We recruited 144 healthy adults to acquire structural neuroimaging data, including T1-weighted images and diffusion tensor images, and data associated with both physical (BMI, blood pressure, and daily time use) and social (subjective socioeconomic status, subjective well-being, post-materialism and Epicureanism) factors. We confirmed that the BHQ was sensitive to an age-related decline in GM volume and WM integrity. Further analysis revealed that the BHQ was critically affected by both physical and social factors. We believe that our BHQ is a simple yet highly sensitive, valid measure for brain health research that will bridge the needs of the scientific community and society and help us lead better lives in which we stay healthy, active, and sharp.

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Neuroimaging Findings Related to Behavioral Disturbances in Alzheimer's Disease: A Systematic Review

Cited by 36 publications

References 83 publications

Neuropsychiatric symptoms and activities of daily living in Alzheimer’s disease: ALSOVA 5-year follow-up study

Neuropsychiatric symptoms and activities of daily living in Alzheimer’s disease: ALSOVA 5-year follow-up study

Risk Factors of Behavioral and Psychological Symptoms in Patients with Alzheimer Disease: The Clinical Research of Dementia of South Korea Study

MRI-based Brain Healthcare Quotients: A bridge between neural and behavioral analyses for keeping the brain healthy

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