Neuroimaging findings in MOGAD -- MRI and OCT

Abstract

Summary Myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are rare in both children and adults, and have been recently suggested to be an autoimmune neuroinflammatory group of disorders that are different from aquaporin-4 autoantibody associated neuromyelitis optica spectrum disorder and from classic multiple sclerosis. In vivo imaging of the MOGAD patient central nervous system has shown some distinguishing features when evaluating magnetic resonance imaging of the brain, spinal cord, optic nerves, as well as retinal imaging using optical coherence tomography. In this review, we discuss key clinical and imaging characteristics of paediatric and adult MOGAD. We describe how these imaging techniques may be used to study this group of disorders and discuss how these imaging methods have led to recent insights for consideration in future studies.

Diagnostik der Neuromyelitis-optica-Spektrum-Erkrankung (NMOSD) und der MOG-Antikörper-assoziierten Erkrankung (MOGAD)

“…In MOGAD, similar to AQP4-IgG+ NMOSD, the lesions are often poorly demarcated and can coalesce. Especially in pediatric MOGAD patients, MRI findings characteristic of ADEM may be present 65 .…”

“…Auch für MOGAD gilt, dass Läsionen oft schlecht demarkiert sind und konfluieren können. Insbesondere bei Kindern mit MOGAD finden sich häufig die typischen MRT-Befunde einer ADEM 65 .…”