Neuroimaging findings and clinical trajectories of Lewy body disease in patients with MCI

Massa, Federico; Arnaldi, Dario; Cesari, Francesca; Girtler, Nicola; Brugnolo, Andrea; Grazzini, Matteo; Bauckneht, Matteo; Meli, Riccardo; Morbelli, Silvia; Pardini, Matteo; Sambuceti, Gianmario; Carli, Fabrizio De; Tiraboschi, Pietro; Nobili, Flavio

doi:10.1016/j.neurobiolaging.2018.12.001

Cited by 25 publications

(26 citation statements)

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“…Imaging of brain metabolism, either through FDG-PET, perfusion SPECT or arterial spin labelled MRI (ASL) [2][3][4] is often done as part of the investigation in dementia patients. Studies with FDG-PET in MCI-LB have found a hypometabolic pattern similar to that seen in dementia with Lewy bodies (DLB) [5], with parieto-occipital hypometabolism [6], and relative preservation of posterior cingulate (cingulate island sign) [7]. Compared with FDG-PET, ASL has the advantage of being cheaper, non-radioactive, and can be done alongside other MR imaging; Dolui [8] compared ASL and FDG in MCI-AD and age matched controls and found similarities between the two techniques, with the hypometabolism patterns in MCI-AD similar to those seen in AD dementia.…”

Section: Introductionmentioning

confidence: 93%

Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling

et al. 2020

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Objective To use arterial spin labelling to investigate differences in perfusion in mild cognitive impairment with Lewy bodies (MCI-LB) compared to Alzheimer type MCI (MCI-AD) and healthy controls. Methods We obtained perfusion images on 32 MCI-LB, 30 MCI-AD and 28 healthy subjects of similar age. Perfusion relative to cerebellum was calculated, and we aimed to examine differences in relative perfusion between MCI-LB and the other groups. This included whole brain voxelwise comparisons, as well as using predefined region-of-interest ratios of medial occipital to medial temporal, and posterior cingulate to precuneus. Differences in occipital perfusion in eyes open vs eyes closed conditions were also examined. Results Compared to controls, the MCI-LB showed reduced perfusion in the precuneus, parietal, occipital and fusiform gyrus regions. In our predefined regions, the ratio of perfusion in occipital/medial temporal was significantly lower, and the posterior cingulate/precuneus ratio was significantly higher in MCI-LB compared to controls. Overall, the occipital perfusion was greater in the eyes open vs closed condition, but this did not differ between groups. Conclusion We found patterns of altered perfusion in MCI-LB which are similar to those seen in dementia with Lewy bodies, with reduction in posterior parietal and occipital regions, but relatively preserved posterior cingulate.

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Section: Introductionmentioning

confidence: 93%

Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling

et al. 2020

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“…Indeed, updated PD diagnostic criteria state that dementia at the time of parkinsonism onset is not an excluding factor for diagnosis (Postuma et al, 2015). Therefore, a PD-MCI diagnosis may also capture prodromal DLB and much existing work in PD-MCI may include prodromal DLB patients (Fujishiro, Nakamura, Sato, & Iseki, 2015;Massa et al, 2019). Massa et al (2019), in recognition of the relevance of this diagnostic issue, recently reported on a small case series of patients that presented first with cognitive impairment and later developed motor symptoms consistent with PD (mean time to PD diagnosis = 2.9 years, range 0.5-6.1), with nearly 50% having converted to dementia at follow-up.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, a PD-MCI diagnosis may also capture prodromal DLB and much existing work in PD-MCI may include prodromal DLB patients (Fujishiro, Nakamura, Sato, & Iseki, 2015;Massa et al, 2019). Massa et al (2019), in recognition of the relevance of this diagnostic issue, recently reported on a small case series of patients that presented first with cognitive impairment and later developed motor symptoms consistent with PD (mean time to PD diagnosis = 2.9 years, range 0.5-6.1), with nearly 50% having converted to dementia at follow-up. Massa et al (2019) note that these patients meet both prodromal DLB (McKeith et al, 2017) and PD with cognitive presentation (Postuma et al, 2015) criteria.…”

Section: Introductionmentioning

confidence: 99%

“…Massa et al (2019), in recognition of the relevance of this diagnostic issue, recently reported on a small case series of patients that presented first with cognitive impairment and later developed motor symptoms consistent with PD (mean time to PD diagnosis = 2.9 years, range 0.5-6.1), with nearly 50% having converted to dementia at follow-up. Massa et al (2019) note that these patients meet both prodromal DLB (McKeith et al, 2017) and PD with cognitive presentation (Postuma et al, 2015) criteria. Moreover, utilising neuroimaging data, they conclude that, "the distinction between prodromal DLB and PD with a cognitive presentation seems blurry at the pathophysiological level, and these patients might be labelled as affected with prodromal LBD, as suggested by some authors (Donaghy & McKeith, 2014;McKeith, 2016)" (Massa et al, 2019, p. 14).…”

Section: Introductionmentioning

confidence: 99%

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The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body Dementias

Ciafone

Little

Thomas

et al. 2019

J Int Neuropsychol Soc

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Objectives:Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) have substantial clinical and biological overlap, with cognitive deficits typically observed in the executive and visuospatial domains. However, the neuropsychological profiles of mild cognitive impairment (MCI) associated with these disorders are not well understood.Methods:This systematic review examined existing literature on cognition in MCI due to LB disease (MCI-LB) and PD (PD-MCI) using an electronic search of seven databases (Medline, Embase, Psychinfo, PubMed, ProQuest, Scopus, and ScienceDirect). MCI-LB results were reviewed narratively given the small number of resulting papers (n = 7). Outcome variables from PD-MCI studies (n = 13) were extracted for meta-analysis of standardised mean differences (SMD).Results:In MCI-LB, executive dysfunction and slowed processing speed were the most prominent impairments, while visuospatial and working memory (WM) functions were also poor. MCI-LB scored significantly lower on verbal memory tests relative to controls, but significantly higher than patients with MCI due to Alzheimer’s disease. Quantitative analysis of studies in PD-MCI showed a similar profile of impairment, with the largest deficits in visuospatial function (Benton Judgement of Line Orientation, SMD g = −2.09), executive function (Trail Making Test B, SMD g = −1.65), verbal ability (Naming Tests, SMD g = −0.140), and WM (Trail Making Test A, SMD g = −1.20). In both MCI-LB and PD-MCI, verbal and visuospatial memory retrieval was impaired, while encoding and storage appeared relatively intact.Conclusions:The findings of this systematic review indicate similar neuropsychological profiles in the MCI stages of DLB and PDD. Executive impairment may at least partially explain poor performance in other domains.

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“…Since only one study met the full inclusion criteria (Massa et al, 2019), we post hoc chose to include studies that did not have HCs and had unclear diagnostic criteria. Doing this we ended up with a total of four articles for this review (Massa et al, 2019;Unger et al, 2019;van de Beek et al, 2020;Yoo et al, 2020). See Table 1.…”

Section: Resultsmentioning

confidence: 99%

The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review

Hemminghyth¹,

Chwiszczuk²,

Rongve³

et al. 2020

Front. Aging Neurosci.

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Objective: Dementia with Lewy Bodies (DLB) is the second most common type of neurodegenerative dementia. Yet, the domain-specific cognitive impairment of the mild cognitive impairment (MCI) phase of this disease (DLB-MCI) is still not been established. This article gives an updated review on the neuropsychological profile of DLB-MCI, building on the findings from a previous review.Methods: We performed systematic review and searched five different electronic databases (Scopus, Cochrane, EMBASE, MEDLINE, and PsycINFO) in May 2020 based on a PICO scheme. Our search was then restricted to articles published in 2019 and 2020. Ending up with a total of 90 articles to be reviewed by abstract and/or full text.Results: In total four papers were included, whereof only one met our full inclusion criteria. Despite a substantial heterogeneity, our findings indicate that DLB-MCI patients have a pattern of executive, visuospatial, and attentional deficits.Conclusion: The findings indicate that the neuropsychological profile of DLB-MCI is characterized by executive, visuospatial, and attentional deficits. Furthermore, the shortage of studies clearly underlines the paucity of published research into DLB-MCI and emphasizes the need for well-controlled studies.

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Neuroimaging findings and clinical trajectories of Lewy body disease in patients with MCI

Cited by 25 publications

References 54 publications

Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling

Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling

The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body Dementias

The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review

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