Neuroimaging Features and Predictors of Outcome in Eclamptic Encephalopathy: A Prospective Observational Study

Junewar, Vivek; Verma, Rajesh; Sankhwar, Pushplata; Garg, Ravi; Singh, Manjeet; Malhotra, Hardeep Singh; Sharma, Payal; Parihar, Anit

doi:10.3174/ajnr.a3923

Cited by 53 publications

(37 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many previous studies, observed hemorrhagic lesions in 9-33% cases of PRES on neuroimaging. 2,7,24,25 In the present study 3 (9.9%) patients with PRES had hemorrhagic complications. This finding is in consistent with study done Moyama et al 6 …”

Section: Figure 1: Persistent Symptomsmentioning

confidence: 85%

“…7 Few studies have reported enhanced maternal deaths in eclampsia associated with PRES. The outcome of pregnant women with PRES was usually reported as favorable, with resolution being rapid and complete after adequate therapy, although permanent damage can persist, and death due to hemorrhage was described.…”

Section: Figure 2a 2b 2c and 2d: Mri Images Of One Of The Patients mentioning

confidence: 99%

“…Magnesium decreases neuronal excitability, protects endothelium against damage by free radicals, or reduces cerebral perfusion pressure. 7,33,34 In central nervous system it may also protect the BBB (blood brain barrier) and there by limit cerebral edema formation.…”

Section: Figure 2a 2b 2c and 2d: Mri Images Of One Of The Patients mentioning

confidence: 99%

“…3 Junewar et al conducted a prospective observational study, to study the predictors of posterior encephalopathy syndrome, but the sample size of the study was small. 7,8 The purpose of this study was to study the maternal and foetal outcome and associated complications in patients with eclampsia with PRES. 4 …”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maternal and perinatal outcome in eclampsia complicated by posterior reversible encephalopathy syndrome; a three years’ experience in a tertiary care hospital

Karanth

Gonsalves

Sheela

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Background: PRES can be associated with number of medical conditions and was observed frequently in patients with preeclampsia and eclampsia. Neuroimaging is important for the diagnosis of PRES. Study was conducted to find out the maternal and perinatal outcome in patients with eclampsia complicated by posterior reversible encephalopathy syndrome (PRES).Methods: This is a retrospective study done at St. Johns Medical College Bangalore, between October 2013 and October 2016. We reviewed case records of all the patients with eclampsia who underwent neuro imaging studies and a diagnosis of PRES was made. The maternal and perinatal outcomes in these women were studiedResults: In the past three years we had 55 cases of eclampsia who underwent neuroimaging studies for persistent neurological symptoms after 24 hours of MgSO4 treatment. Of these women 30 were diagnosed to have PRES. In the present study PRES was common in multiparous women and more in patients with antepartum eclamptic women. Mean age at diagnosis of PRES was 26±5.1 years. Common presenting symptoms were headache (93.3%) and vomiting (53.3%). The mean SBP/DBP was 180/110 mmHg. All patients who had recurrent seizures were controlled with MgSO4 alone. 53.3% of our patients had eclampsia related complications and 36.7% required ICU care. There were 3 maternal deaths (10%). Perinatal mortality was 20%.Conclusions: Neuroimaging in eclamptic patients with persistent neurological symptoms could help in early diagnosis of PRES and multidisciplinary approach in management could contribute significantly in reducing the maternal mortality and morbidity.

show abstract

Section: Figure 1: Persistent Symptomsmentioning

confidence: 85%

Section: Figure 2a 2b 2c and 2d: Mri Images Of One Of The Patients mentioning

confidence: 99%

Section: Figure 2a 2b 2c and 2d: Mri Images Of One Of The Patients mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal and perinatal outcome in eclampsia complicated by posterior reversible encephalopathy syndrome; a three years’ experience in a tertiary care hospital

Karanth

Gonsalves

Sheela

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…Hence their elevation just suggests diffuse endothelial dysfunction, and absolute values may not correlate with the degree of cerebral endothelial dysfunction and hence with severity of cerebral edema or, for that matter, the extent of edema. 3 Therefore, more studies are required not only warranting the exact relationship of serum LDH with severity of cerebral edema in PRES, but also trying to identify specific biomarkers of cerebral vascular endothelium and establishing its relationship with the severity of PRES.…”

mentioning

confidence: 99%