Neuroimaging correlates of subjective memory deficits in a community population

Stewart, Robert; Dufouil, Carole; Godin, O.; Ritchie, Karen; Maillard, Pauline; Delcroix, Nicolas; Crivello, Fabrice; Mazoyer, Bernard; Tzourio, Christophe

doi:10.1212/01.wnl.0000310982.99438.54

Cited by 109 publications

(120 citation statements)

References 35 publications

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“…Two studies found an association between WMH and SCF after adjustment for possible confounders in nondemented elderly from the general population. 15,16 The contradicting results might be explained by the different sample or by a lack of statistical power in our study because our sample size was relatively small compared with these studies (n=109 versus n=1779 and n=1049, respectively).…”

Section: Discussioncontrasting

confidence: 56%

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Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

et al. 2014

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Subjective cognitive failures (SCF) are a common feature in elderly people with cardiovascular disease.1 SCF are personal experiences of cognitive problems in everyday life, such as difficulties in memory (eg, forgetfulness), information processing speed (eg, slowness in performing simple tasks), and executive function (eg, problems in planning or reasoning). Although these subjective problems are common, it is not completely clear what they represent. The relationship with objective cognitive performance on neuropsychological assessment is unclear. Although most studies showed no relationship with objective cognitive impairment when corrected for mood and health, 1-6 some studies reported positive associations. 7,8 However, studies have shown a strong association with poor physical health 6 and depression. 2,6Research on SCF in patients with hypertension is scarce, despite the increasing support for an association between hypertension and objective cognitive impairment, 9-11 which might be because of brain damage. Hypertension is a major risk factor for white matter hyperintensities (WMH) 12 and other magnetic resonance imaging (MRI) manifestations of cerebral small vessel disease (cSVD), 13 which include lacunes, cerebral microbleeds, and perivascular spaces.14 A possible association between SCF and cSVD-related brain damage, as proposed by previous research, 1,15,16 and objective cognitive impairment has not been examined before in patients with hypertension.Patients with hypertension expressing SCF may be a recognizable situation for clinicians. To gain more knowledge about the implications of SCF in patients with hypertension, this study investigated whether SCF are associated with objective cognitive impairment, independent of confounding factors, such as age, sex, symptoms of anxiety and depression, and vascular risk factors. In addition, we examined whether SCF are predictive for the presence of MRI markers of cSVD.Abstract-Previous studies on the relationship between subjective cognitive failures (SCF) and objective cognitive function have shown inconsistent results. In addition, research on the association between SCF and imaging markers of cerebral small vessel disease is limited. We investigated whether SCF in patients with essential hypertension, who are at high risk of cerebral small vessel disease, are associated with objective cognitive function and magnetic resonance imaging manifestations of cerebral small vessel disease. We included 109 patients with hypertension who underwent extensive neuropsychological assessment, including questionnaires measuring SCF and symptoms of anxiety and depression. Brain magnetic resonance imaging was performed to rate the presence of lacunes, cerebral microbleeds, and perivascular spaces, as well as white matter hyperintensities volume. Results showed significant associations between SCF and objectively measured overall cognition (B=−0.02; 95% confidence interval=−0.03 to −0.005), memory (B=0.02; 95% confidence interval=−0.03 to −0.004), and information processin...

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Section: Discussioncontrasting

confidence: 56%

“…14 A possible association between SCF and cSVD-related brain damage, as proposed by previous research, 1,15,16 and objective cognitive impairment has not been examined before in patients with hypertension.…”

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confidence: 97%

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

et al. 2014

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“…44 In community settings, 20% of individuals with SMC are likely to have dementia and 30% MCI. 38 Establishing the presence of SMCs may prove useful as they have been associated with characteristic neuroimaging changes in the temporal and hippocampal regions 45 , and may represent a degree of cognitive impairment that is not currently measurable by objective tests. 46 SMCs may therefore represent a simple and cost-effective way of identifying underlying impairment which would obviate the need for validated tools and trained administration staff.…”

Section: Performance Of Toolsmentioning

confidence: 99%

Screening a heterogeneous elderly South African population for cognitive impairment: the utility and performance of the Mini-Mental State Examination, Six Item Screener, Subjective Memory Rating Scale and Deterioration Cognitive Observee

et al. 2013

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Objective: The aim of this study was to report on the prevalence of cognitive impairment, and to assess the performance and utility of subjective, objective and informant screening tools in a heterogeneous community sample. Method: A sample of 302 elderly participants (>60 years) living in residential homes in a large city in South Africa were screened for the presence of cognitive impairment using objective (Mini-Mental ) screening tools. All tools were compared to the MMSE and the influence of demographic variables on the performance on these tools was considered. Results: Significantly lower MMSE scores were found in participants aged 80-89 years (p=.023) and those who had 8-11 years of education (p=.002). For every one additional year of education, participants were 0.71 times less likely to screen positive on the MMSE. Differential item functioning on various components of the MMSE was demonstrated due to the effects of education, race and gender. There was significant differential performance between the recommended and alternate attention/concentration items (p<.001) with the alternate item favouring better performance. Based on the MMSE cutoff score of < 23, the prevalence of cognitive impairment was 16.9%; the prevalence yielded by the remaining tools ranged from 10.5% using the DECO to 46% as determined by the presence of a SMC. Using the MMSE as the reference standard for the presence of cognitive impairment, the SIS, SMC, SMRS and DECO had sensitivities of 82.3%, 54.6%, 17.0% and 37.5%, and specificities of 71.3%, 57.6%, 87.4% and 96.7% respectively. Age and race influenced performance on the MMSE, SIS and SMRS. Conclusion: Different types of cognitive screening tools yielded varying sensitivities and specificities for identifying cognitive impairment when compared to the MMSE. The influence of race, age and education on test performance highlights the need for suitable, culture-fair screening tools. Locally, the alternate item for attention/concentration should be preferred. However, the serious consequences of population ageing do not appear to be planned for as evidenced by the lack of a national dementia care policy. There is a lack of recent data on morbidity as well as a paucity of research particularly in the areas of cognitive, mental and physical functioning of the elderly. 3 Dementia, a condition largely affecting the aged, requires specialised services, few of which exist either in the public or private health sector in South Africa. The projected increase in the prevalence of Afr J Psychiatry 2013;16:445-455 ORIGINAL

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“…Each subject data set (T1, T2, and proton density) was readily reconstructed and visually checked for major artifacts before being sent to the database repository (Caen) where it was archived for further analyses. As described in a previous publication, 24 we used the so-called optimized voxel-based morphometry protocol to compute gray matter, white matter (WM), and cerebrospinal fluid volumes of each subject. Total intracranial volume was computed as the sum of the gray matter, WM, and cerebrospinal fluid volumes (both ventricular and extracranial cerebrospinal fluid).…”

Section: Baseline Mri Datamentioning

confidence: 99%

Cerebral White Matter Lesions Are Associated With the Risk of Stroke But Not With Other Vascular Events

Buyck

Dufouil²,

Mazoyer³

et al. 2009

Stroke

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Background and Purpose-White matter lesions (WMLs) have been shown to be associated with the risk of stroke in previous studies but little is known about the prediction of other vascular events. We evaluated the risk of stroke and other vascular events according to WML volume in a large population-based sample. We also studied WML volume by type (deep or periventricular) in relation to these events. Methods-The 3-City Study is a population-based prospective cohort of people aged Ն65 years followed up for, on average, 4.9 years. Among them, 1643 participants free of prevalent vascular events had quantitative measurements of WML volume at baseline using a fully automatic method. The risks of incident major vascular events according to WML volume were evaluated using Cox proportional hazards models. Results-The risk of incident stroke significantly increased with increasing baseline WML volume and was multiplied by 5 for those in the highest quartile of WML volume. Nonstroke vascular events' incidence was not associated with WML volumes, whatever their type. Conclusions-WMLs are an independent predictor of stroke in the elderly. This association is specific because WMLs are not associated with the risk of other vascular events.

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Neuroimaging correlates of subjective memory deficits in a community population

Cited by 109 publications

References 35 publications

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

Subjective Cognitive Failures in Patients With Hypertension Are Related to Cognitive Performance and Cerebral Microbleeds

Screening a heterogeneous elderly South African population for cognitive impairment: the utility and performance of the Mini-Mental State Examination, Six Item Screener, Subjective Memory Rating Scale and Deterioration Cognitive Observee

Cerebral White Matter Lesions Are Associated With the Risk of Stroke But Not With Other Vascular Events

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