Neuroimaging correlates of false memory in 'Alzheimer's disease: A preliminary systematic review

Abstract

Alzheimer's disease (AD) is characterised by episodic memory impairment, but people also experience memory distortions, including false memories, which can impact on safety and reduce functioning. Understanding the neural networks that underpin false memories could help to predict the need for intervention and guide development of cognitive strategies to reduce memory errors. However, there is a relative absence of research into how the neuropathology of AD contributes to false memory generation. This paper systematically reviews the methodology and outcomes of studies investigating the neuroimaging correlates of false memory in AD. Four studies using structural imaging and three studies using functional imaging were identified. Studies were heterogenous in methodology and received mostly 'weak' quality assessment ratings. Combined, and consistent with neuroimaging findings in non-AD populations,

Effectiveness of tDCS to Improve Recognition and Reduce False Memories in Older Adults

“…Decreased hippocampal volume is associated with reduced memory performance [4], and decreased anterior, dorsolateral, and ventrolateral PFC is associated with reduced memory capacity [5]. Decreased structure and function of MLT and PFC are also associated with increased susceptibility to false memories [6]. Older adults with smaller hippocampal volume generate more false alarms on associative recognition tasks than older adults with larger volumes [7].…”

Evaluación neuropsicológica en estados confabulatorios

“…Según Green y Loprinzi (2019), la confabulación se debe a un monitoreo de fuentes de una realidad imperfecta frente a una expectativa cultural determinada. El término falsa memoria también ha sido usado para describir un amplio rango de este fenómeno, e incluye mal recuerdo de las listas de palabras, falsos reconocimiento y distorsiones en la memoria autobiográfica y falsas creencias, pero relatadas de una forma más elaborada (McLachlan et al, 2019;Robins, 2018).…”

“…Asimismo, se ha encontrado que los pacientes con enfermedad de Alzheimer tienen mayor tendencia a confabulaciones provocadas que un grupo control, y que la confabulación se incrementa cuando la información sobreaprendida reemplaza pobremente a la información codificada por bajo monitoreo en la memoria, lo que deja ver de alguna manera que se requiere cierto grado de adecuada función del hipocampo para generar confabulaciones (McLachlan et al, 2019;Molina, 2016;Terranova et al, 2019;Zoladz et al, 2017).…”

“…Otros estudios imagenológicos han mostrado hallazgos relacionados con el lóbulo temporal medial y la conectividad reducida entre corteza orbitofrontal derecha, hipocampo derecho, uncus y corteza orbitofrontal izquierda, parahipocampo izquierdo, y giro fusiforme en pacientes confabuladores; además el hipometabolismo en regiones entorrinal y perirrinal izquierda y en corteza dorsolateral derecha, se correlacionan con errores de intrusión; el volumen del cíngulo anterior parece correlacionarse negativamente con la confabulación (McLachlan et al, 2019;Terranova et al, 2019;Voss et al, 2019;Zoladz et al, 2017).…”

Effectiveness of tDCS at Improving Recognition and Reducing False Memories in Older Adults

“…Decreased hippocampal volume is associated with reduced memory performance [4], and a decreased anterior, dorsolateral, and ventrolateral PFC is associated with reduced memory capacity [5]. Decreased structure and function of the MTL and PFC are also associated with increased susceptibility to false memories [6]. Older adults with smaller hippocampal volumes generate more false alarms on associative recognition tasks than older adults with larger volumes [7].…”