Neuroimaging Advances in Preclinical Alzheimers disease

Abstract

Alzheimer's disease (AD) is considered as a continuously pathological continuum. The AD pathophysiological process begins decades before the emergence of clinical symptoms. Recently, due to the advanced neuroimaging techniques and biochemical tests, various biomarkers are gradually identified, providing the ability to detect the evidence of AD pathology in the preclinical stage and further intervene the process of disease. Multimodal magnetic resonance imaging (MRI), with relatively non-invasive and economic benefits, is of great values to promote the clinical application. Therefore, researches involving brain structural and functional alterations in preclinical AD are summarized in this review.