Neurohypophyseal hormones and brain neurochemistry

Versteeg, Dirk H.G.

doi:10.1016/0163-7258(82)90071-7

Cited by 45 publications

(12 citation statements)

References 135 publications

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“…AVP also acts on biochemical and electrophysiological processes in these areas. It was found that the peptide affects indices for catecholamine turnover in the hippocampal dentate gyrus, dorso-lateral septum and nucleus tractus solitarii (NTS) [7,12], and alters the firing pattern of neurons in the lateral septum [5]. Immunocytochemical studies have demonstrated that these limbic-midbrain regions are innervated by AVPcontaining neurons [3].…”

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confidence: 99%

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Arginine-vasopressin binding sites in rat brain: A quantitative autoradiographic study

Biegon

Terlou

Voorhuis

et al. 1984

Neuroscience Letters

120

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Specific binding sites for arginine-vasopressin (AVP) were detected in rat brain after incubation of tissue sections with [3H]AVP. AVP and two selective AVP antagonists are capable of displacing [3H]AVP with an ICso in the 10-s-10 -7 molar range, while oxytocin and ACTH4-l0 were much less effective. The neuroanatomical distribution of [3H]AVP-labeled sites was studied with autoradiography utilizing tritium-sensitive LKB film and computerized densitometry for quantitative analyses of the film images. The highest density of [3H]AVP binding sites was observed in hippocampal regions, the lateral septum, olfactory and amygdaloid nuclei, and the nucleus tractus solitarii (NTS) of the brainstem.Arginine-vasopressin (AVP) influences memory processes [4,6]. This action of AVP takes place in certain discrete limbic-midbrain regions [7]. AVP also acts on biochemical and electrophysiological processes in these areas. It was found that the peptide affects indices for catecholamine turnover in the hippocampal dentate gyrus, dorso-lateral septum and nucleus tractus solitarii (NTS) [7,12], and alters the firing pattern of neurons in the lateral septum [5]. Immunocytochemical studies have demonstrated that these limbic-midbrain regions are innervated by AVPcontaining neurons [3]. Recent advances in autoradiographic methods introduced by Kuhar and coworkers [8] have made it possible to study receptor distribution in vitro in brain sections. A modification using tritium-sensitive sheet film has been introduced [9]. Based on this method preliminary reports have appeared showing that autoradiography of [3H]AVP binding sites is feasable [2,10,13]. In the present *On leave of absence from the

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confidence: 99%

“…The hippocampal, septal and amygdaloid regions have been demonstrated to respond to microinfusion of AVP and related peptides as measured by indices of behavioral performance [4] and catecholamine neurotransmission [7,12]. The NTS has a role in blood pressure regulation.…”

mentioning

confidence: 99%

Arginine-vasopressin binding sites in rat brain: A quantitative autoradiographic study

Biegon

Terlou

Voorhuis

et al. 1984

Neuroscience Letters

120

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“…Therefore, the effect of oxytocin on the disappearance of noradrenaline and dopamine induced by a -methyl-p-tyrosine was studied in a selected number of nuclei in the brain. The selection of these nuclei was based on knowledge about the anatomy of the oxytocin-containing systems in the brain (see Buys, 1983) and on the previous reports of the effects of vasopressin and oxytocin on brain function (Tanaka et al, 1977a, b;Kovacs et al, 1979a, b,c;Van Heuven-Nelsen et al, unpublished;Versteeg, 1983).…”

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confidence: 99%

Oxytocin affects utilization of noradrenaline in distinct limbic-forebrain regions of the rat brain

1984

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Summary-The effects of oxytocin, administered intracerebroventricularly in doses of 1, 10, 100 and IOOOpmol, were studied on the disappearance of catecholamines induced by a-methyl-p-tyrosine in microdissected nuclei of the rat brain. Oxytocin dose-dependently decreased the utilization of noradrenaline in the lateral and medial septal nuclei and anterior hypothalamic area, whereas an enhanced utilization was observed in the nucleus supraopticus. Tendency towards a change in utilization of noradrenaline was found in the dorsal septal nucleus and the lateral amygdala. Utilization of dopamine was not significantly affected in any of the nuclei of the brain studied. Tendency towards a decrease in utilization of dopamine was observed in the nucleus caudatus, globus pallidus and medial septal nucleus. It thus appears that oxytocin elicited changes in only a restricted number of brain nuclei. Interestingly, these nuclei contain cell bodies (nucleus supraopticus) and terminals (other nuclei) of the oxytocin system in the brain. Though the effects of oxytocin were not as widespread as those previously seen after administration of vasopressin, it is worthy of note that, in general, the effects of oxytocin were opposite to those seen after vasopressin. The opposite effecs of vasopressin and oxytocin on catecholamine metabolism could be related to the opposite effects of the two peptides on behaviour, neuroendocrine and autonomic regulation.

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“…The reported data are however difficult to interprete since the effects seem to depend on the dose of the peptide, the time that elapsed after peptide administration, the brain structure investigated, the method of determination of catecholaminergic activity, etc. (4). Thus, whether neurochemical data can support the interaction between neurohypophyseal peptides and presynaptically located dopaminergic systems, as suggested by the present findings, can not be answered at the moment.…”

Section: Resultsmentioning

confidence: 61%

“…Thus, these neuropeptides influence memory processes, attenuate experimentally induced amnesia, affect the development of tolerance to morphine, change acquisition of heroin self-administration and modify the electrical activity of the brain. It has been postulated that these effects are mediated by an interaction of these neuropeptides with brain catecholamine systems (2,4). Indeed, systemic, intracerebroventricular and intracerebral administration of these peptides affect dopaminergic and noradrenergic activities in various brain areas (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Neuropeptides related to neurohypophyseal hormones interfere with apomorphine-induced behavioral changes

1984

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The interaction between peptides related to neurohypophyseal hormones and brain dopaminergic systems was studied by investigating in rats the effect of these peptides on behavioral changes induced by graded doses of the specific dopamine agonist apomorphine. Low doses of this drug induce hypoactivity of the animals, while higher doses result in hyperactivity and stereotyped sniffing. Desglycinamideg[Arg8]vasopressin (DG-AVP), prolyl-leucyl-glycinamide (PLG) and oxytocin did not interfere with the behavioral responses induced by the higher doses of apomorphine. Peptide treatment made the rats more sensitive to apomorphine with respect to the drug induced hypoactivity. PLG and especially DG-AVP were more effective than oxytocin. It is concluded that these peptides may have a selective action on distinct dopaminergic receptor systems in the brain, that are presumably located presynaptically in the nucleus accumbens area.

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Neurohypophyseal hormones and brain neurochemistry

Cited by 45 publications

References 135 publications

Arginine-vasopressin binding sites in rat brain: A quantitative autoradiographic study

Arginine-vasopressin binding sites in rat brain: A quantitative autoradiographic study

Oxytocin affects utilization of noradrenaline in distinct limbic-forebrain regions of the rat brain

Neuropeptides related to neurohypophyseal hormones interfere with apomorphine-induced behavioral changes

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