Neurohormonal control of pancreatic secretion

Singh, Manjit; Webster, Peter

doi:10.1016/0016-5085(78)90812-0

Cited by 78 publications

(39 citation statements)

References 137 publications

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“…Neurotransmitters and hormones interact in a very complex manner, so that it is difficult to differentiate the relative influence of each factor. The sympathetic nervous system has in earlier studies been suggested to have an inhibitory effect on pancreatic exocrine secretion [12,20]. This is consistent with our findings, which showed that interruption of the inhibition by selective sympathetic denervation of the pancreas leads to an increase in exocrine secretion.…”

Section: Discussionsupporting

confidence: 96%

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The effect of selective sympathetic denervation on pancreatic exocrine secretion

et al. 1997

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The purpose of this study was to investigate the influence of selective sympathetic denervation of the rat pancreas on exocrine secretion and to study whether the observed effects were due to pancreatic trophism. Sprague-Dawley rats were divided into two groups. One group underwent selective sympathetic denervation by skeletonizing the superior and inferior pancreaticoduodenal and splenic arteries. The other group underwent simple laparotomy and served as controls. One week after the operation a catheter was introduced into the bile-pancreatic duct and pancreatic juice was collected at 30-min intervals for 4 h. The output of bicarbonate, total protein, amylase, trypsin, chymotrypsin, lipase, colipase and carboxyesterlipase were determined. Following denervation secretion of pancreatic enzymes was significantly enhanced compared with sham-operated animals. We did not find any signs of pancreatic trophism 1 week after denervation.

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Section: Discussionsupporting

confidence: 96%

“…It is well established that pancreatic exocrine secretion is under neurohumoral control [1,12,20]. Neurotransmitters and hormones interact in a very complex manner, so that it is difficult to differentiate the relative influence of each factor.…”

Section: Discussionmentioning

confidence: 99%

The effect of selective sympathetic denervation on pancreatic exocrine secretion

et al. 1997

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“…Abolition of the early (vagally dependent) amylase response in the latency studies caused by L-364,718 (Niebergall-Roth et al, 2000b) points to a pivotal role of endogenous CCK within the enteropancreatic reflex. An intriguing and valid model integrating these findings with the humoral mode of action of CCK in dogs (Vazquez-Echarri et al, 1986b;Niebergall-Roth et al, 1997, 2000a; see above) was suggested by Grossman (see Singer, 1993) back in 1980. Grossman hypothesized that when low loads of nutrients reach the small intestine, only small amounts of CCK would be released from duodenal endocrine cells that would not be discharged into the bloodstream, but would diffuse across the intracellular space to neural CCK receptors and initiate a vago-vagal enteropancreatic reflex.…”

Section: Speciesmentioning

confidence: 92%

Secretion from acinar cells of the exocrine pancreas: Role of enteropancreatic reflexes and cholecystokinin

Singer

Niebergall-Roth

2009

Cell Biology International

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Although the molecular machinery and mechanism of cell secretion in acinar cells of the exocrine pancreas is well documented and clear, only recently has the pharmacophysiology of pancreatic exocrine secretion come to light. Therefore, we focus in this article on the current understanding of the pharmacophysiology of pancreatic exocrine secretion. The pancreatic secretory response to ingestion of a meal is mediated via a complex interplay of neural, humoral and paracrine mediators. A major role in the control of the intestinal phase of pancreatic secretion is attributed to vago-vagal enteropancreatic reflexes. In the scheme of this control mechanism, afferents originating in the duodenal mucosa, and efferents mediating central input on the pancreatic ganglia, activate intrapancreatic postganglionic neurons. Experiments utilizing specific receptor antagonists demonstrate the involvement of both muscarinic M1 and M3 receptors expressed in pancreatic acinar cells. Cholecystokinin (CCK), originally implicated in the humoral secretion of pancreatic enzymes, through a direct action on acinar CCK receptors, is also essential to the enteropancreatic reflex mechanism. CCK stimulation of the exocrine pancreatic secretion through excitation of sensory afferents of the enteropancreatic reflexes, is a paracrine mode of CCK action, and is probably the only one in humans and the predominant one in rats. In dogs, however, CCK acts on the pancreas via both the humoral and a paracrine route. More recent experiments suggest further possible sites of CCK action. Additionally, at the brain stem, vago-vagal enteropancreatic reflexes may be modulated by input from higher brain centres, particularly the hypothalamic-cholinergic system in the tonic stimulation of preganglionic neurons of the dorsal motor nucleus of the vagus projecting into the pancreas.

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“…The denervated gland is as sensitive as the intact pancreas to exogenous caerulein. Furthermore, the autotransplanted pancreas, which is extrinsically denervated, can be used as a sensitive monitor to plasma hormone levels since it can only respond to humoral stimulants (21,22,26).…”

Section: Discussionmentioning

confidence: 99%

“…Stimulation of the vagus nerve provokes a secretory response of pancreatic juice of high-specific gravity, rich in enzymes with only a modest increase in volume (11,12). This response can be mimicked by cholinergic drugs (13,14) and blocked by atropine and vagotomy (15)(16)(17). It seems that the vagus nerves are the principal efferent pathways by which stimuli in the cephalic region (6,11,12,18) and stomach (15,16,19,20) reach the pancreas; in other words the vagus mediates in the "cephalic" and "gastric" phase of pancreatic secretion and also mediates the "intestinal" phase via enteropancreatic reflexes (21,22).…”

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confidence: 99%

Exocrine Pancreatic Function in Dogs with Denervated Pancreas

Köhler

Nustede²,

Barthel³

et al. 1987

Pancreas

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There is strong evidence that the vagus nerve plays an important role in exocrine pancreatic secretion. In the present study we examined the effect of total extrinsic denervation of the pancreas on exocrine pancreatic secretion to different stimuli in dogs. In the experiments we used the model of the orthotopic autotransplanted dog pancreas as described by Debas et al. Denervation of the gland did not significantly alter water and bicarbonate response to secretin. The dose-response curve of caerulein showed the denervated pancreas as sensitive as the intact gland. However, autotransplantation of the pancreas caused a significant decrease (p < 0.0.5) in protein secretion during intraintestinal L-tryptophan in increasing doses. Furthermore, bicarbonate and protein secretion after food intake was significantly decreased in the denervated pancreas (protein: peak levels 380 mg/15 min and 135 mg/l5 min; bicarbonate: 3.2 mEq/l5 min and 1.4 mEq/l5 min) (p < 0.02). From our data we conclude that the denervated pancreas is as sensitive as the intact pancreas to stimulation by exogenous secretin and caerulein, whereas denervation of the pancreas causes an important influence in the intestinal phase of pancreatic secretion.

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Neurohormonal control of pancreatic secretion

Cited by 78 publications

References 137 publications

The effect of selective sympathetic denervation on pancreatic exocrine secretion

The effect of selective sympathetic denervation on pancreatic exocrine secretion

Secretion from acinar cells of the exocrine pancreas: Role of enteropancreatic reflexes and cholecystokinin

Exocrine Pancreatic Function in Dogs with Denervated Pancreas

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