Neurohormonal and cytokine fluctuations following transcatheter closure for an atrial septal defect

Chamakou, Aikaterini; Dede, Eleni; Moutafi, Antonia C.; Thanopoulos, Vassileios; Chryssanthopoulos, Stavros; Loukopoulou, Sophia; Pitsavos, Christos; Stefanadis, Christodoulos; Davos, Constantinos H.

doi:10.1016/j.cyto.2011.10.002

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…In our study no significant increase in NT-proBNP was found one day after ASD closure, this is in contrast to several studies that did find an increase [25] , [26] . An explanation for the absence of an increase in our study may be the presence of already relatively high levels of NT-proBNP before closure.…”

Section: Discussioncontrasting

confidence: 99%

Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults

Geenen

Assis

Baggen

et al. 2020

IJC Heart & Vasculature

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Highlights A substantial number of adults with unrepaired ASD have elevated biomarker levels. Percutaneous ASD closure in adults leads to acute changes in most biomarker levels. TnT, CRP, RDW, GDF-15 increase immediate after ASD closure and galectin-3 decreases. Long-term reverse cardiac remodeling was not reflected by a decrease in biomarkers. Novel biomarkers can help to elucidate mechanisms of reverse cardiac remodeling.

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Section: Discussioncontrasting

confidence: 99%

Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults

Geenen

Assis

Baggen

et al. 2020

IJC Heart & Vasculature

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“…A few months post procedure, a decrease in brain natriuretic peptide levels was observed and they became comparable to pre-procedural levels or even lower (Fig 4). 8,10,13,15,16,19,20 When brain natriuretic peptide values were measured 1 year after closure, levels in percutaneously treated patients were comparable to those of control patients. However, surgically treated patients still revealed elevated brain natriuretic peptide levels 1 year after the procedure.…”

Section: Atrial Septal Defectmentioning

confidence: 84%

“…18 In eight studies, longitudinal data were available, describing sequential brain natriuretic peptide measurement before and after percutaneous or surgical atrial septal defect closure. 6,8,10,13,15,16,19,20 Initially, brain natriuretic peptide levels increased notably within days after atrial septal defect closure (Fig 3). A few months post procedure, a decrease in brain natriuretic peptide levels was observed and they became comparable to pre-procedural levels or even lower (Fig 4).…”

Section: Atrial Septal Defectmentioning

confidence: 97%

“…We included 17 articles reporting data on brain natriuretic peptide values in patients with unrepaired atrial septal defect, describing a total of 429 patients with a mean/median age ranging from 4 to 75.8 years. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] No studies describing brain natriuretic peptide in repaired atrial septal defect patients were found. A significant difference was observed for all ages in brain natriuretic peptide levels between patients with atrial septal defect (mean/median values of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide ranging from 10.6 to 175.9 picograms per millilitre and 35.2 to 240 picograms per millilitre, respectively) and healthy age-matched controls (mean/median values of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide ranging from 5.3 to 32.6 picograms per millilitre and 4.04 to 59 picograms per millilitre, respectively; Fig 2).…”

Section: Atrial Septal Defectmentioning

confidence: 99%

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The usefulness of brain natriuretic peptide in simple congenital heart disease – a systematic review

Eindhoven¹,

Bosch

Boersma

et al. 2012

Cardiol Young

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Brain natriuretic peptide and N-terminal pro-brain natriuretic peptide are two well-established markers for cardiac failure in acquired heart disease. Nevertheless, the clinical utility of these markers in patients with congenital heart disease remains unclear. Therefore, the aim of this study was to evaluate the diagnostic and prognostic value of these markers in patients with congenital heart disease. A PubMed and EMBASE literature search was executed with focus on the most common simple congenital heart defects, atrial septal defect and ventricular septal defect. Data on brain natriuretic peptide measurement, cardiac function parameters, and follow-up were collected. In patients with atrial or ventricular septal defect, brain natriuretic peptide levels were mildly increased when compared with healthy age-matched controls. Shunt severity and pulmonary artery pressure correlated strongly with natriuretic peptide levels. A clear association between brain natriuretic peptide and functional class was demonstrated. After closure of the defect, a rise in brain natriuretic peptide levels in the first hours to days was observed. After longer follow-up, natriuretic peptide levels decreased and became comparable to pre-procedural values. In conclusion, this systematic review shows that brain natriuretic peptide levels are mildly increased in patients with unrepaired and repaired atrial or ventricular septal defect. Brain natriuretic peptide measurement might be a useful additional tool in the diagnostic work-up of patients with atrial or ventricular septal defect. Further investigation in a larger, prospective study with long-term follow-up is warranted to elucidate the true prognostic value of natriuretic peptides in patients with simple congenital heart disease.

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“…Chamakou et al found increased Interleukin 6 levels pre-operatively in patients with an ASD admitted for transcatheter closure of the defect compared with healthy controls. Interleukin 6 decreased to control levels 3 months postoperatively, suggesting that closure of the defect may normalize Interleukin 6 levels ( 26 ). Remarkably, we found higher levels of 24 inflammatory biomarkers in patients with a spontaneously closed ASD when comparing with controls.…”

Section: Discussionmentioning

confidence: 99%

Increased inflammatory markers in adult patients born with an atrial septal defect

Schram

Sellmer²,

Nyboe³

et al. 2022

Front. Cardiovasc. Med.

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Patients with atrial septal defect (ASD) have higher mortality and higher risk of atrial fibrillation, heart failure, pneumonia, and stroke than the general population even if the ASD closes spontaneously in childhood. The reason for the long-term complications remains unknown. Since many of the complications can be linked up with alterations in inflammatory response, we speculate that inflammation may contribute to the association between ASD and morbidity and mortality. We investigated inflammatory activity in adults with an ASD compared with controls. We included 126 adults with an unrepaired ASD. A group of healthy controls were recruited as comparison group (n = 23). Serum samples were analyzed for 92 inflammation-related protein biomarkers using a proximity extension assay. A pathway enrichment analysis was performed using Reactome database. Out of 92 biomarkers, 73 were eligible for data analysis. Increased levels of 14 (19%) biomarkers were found in patients with open ASD and 24 (33%) biomarkers in patients with spontaneously closed defects compared with controls (p < 0.05). Multiple inflammatory pathways showed stronger enrichment in both patient groups when compared with controls. In conclusion, inflammatory activity is altered in adult patients with an unrepaired ASD compared with healthy controls. The increased inflammatory burden of patients with an unrepaired ASD may contribute to the development of morbidities.

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Neurohormonal and cytokine fluctuations following transcatheter closure for an atrial septal defect

Cited by 6 publications

References 29 publications

Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults

Evolution of blood biomarker levels following percutaneous atrial septal defect closure in adults

The usefulness of brain natriuretic peptide in simple congenital heart disease – a systematic review

Increased inflammatory markers in adult patients born with an atrial septal defect

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