Neurohormonal activation and diagnostic value of cardiac peptides in patients with suspected mild heart failure

Mikkelsen, Kurt V.; Bie, Peter; Møller, Jacob Eifer; Videbæk, Lars; Villadsen, Henrik D.; Haghfelt, Torben

doi:10.1016/j.ijcard.2005.08.003

Cited by 9 publications

(2 citation statements)

References 45 publications

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“…[220]To evaluate whether BNP measurement associated with echocardiography could effectively stratify patients with new symptomsCSS4A+Mikkelsen et al. [221]To assess diagnostic accuracy of cardiac peptides in detecting any left ventricular dysfunction (LVD) in patients referred from primary care with suspected HF before institution of medical therapyCSS4A+Fuat et al. [222]To test and compare the diagnostic accuracy and utility of B‐type natriuretic peptide (BNP) and N‐terminal B‐type natriuretic peptide (NT proBNP) in diagnosing heart failure due to left ventricular systolic dysfunction in patients with suspected heart failure referred by GPs to one‐stop diagnostic clinicsCSS4A+…”

Section: Management Outside Hospitalmentioning

confidence: 99%

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Guidelines for the management of adult lower respiratory tract infections - Full version

Woodhead

Blasi

Ewig

et al. 2011

Clinical Microbiology and Infection

793

616

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This document is an update of Guidelines published in 2005 and now includes scientific publications through to May 2010. It provides evidence-based recommendations for the most common management questions occurring in routine clinical practice in the management of adult patients with LRTI. Topics include management outside hospital, management inside hospital (including community-acquired pneumonia (CAP), acute exacerbations of COPD (AECOPD), acute exacerbations of bronchiectasis) and prevention. Background sections and graded evidence tables are also included. The target audience for the Guideline is thus all those whose routine practice includes the management of adult LRTI.

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Section: Management Outside Hospitalmentioning

confidence: 99%

“…A number of new studies on the diagnosis of cardiac failure in primary care were found, but none involving patients with a cough. The presence of hypertension and atrial fibrillation is associated with cardiac failure, and levels of BNP and NT-proBNP were found to have diagnostic value for detecting cardiac failure [220][221][222].…”

Section: Introductionmentioning

confidence: 99%

Guidelines for the management of adult lower respiratory tract infections - Full version

Woodhead

Blasi

Ewig

et al. 2011

Clinical Microbiology and Infection

793

616

View full text Add to dashboard Cite

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Outpatient Evaluation for Cardiovascular Diseases Using Natriuretic Peptide Testing

Baggish¹,

Januzzi²

2007

Markers in Cardiology

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Sensitivity and specificity of NT-proBNP to detect heart failure at post mortem examination

et al. 2011

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NT-proBNP, a marker of cardiac failure, has been shown to be stable in post mortem samples. The aim of this study was to assess the accuracy of NT-proBNP to detect heart failure in the forensic setting. One hundred sixty-eight consecutive autopsies were included in the study. NT-proBNP blood concentrations were measured using a chemiluminescent immunoassay kit. Cardiac failure was assessed by three independent forensic experts using macro- and microscopic findings complemented by information about the circumstances of body discovery and the known medical story. Area under the receiving operator curve was of 65.4% (CI 95%, from 57.1 to 73.7). Using a standard cut-off value of >220 pg/mL for NT-proBNP blood concentration, heart failure was detected with a sensitivity of 50.7% and a specificity of 72.6%. NT-proBNP vitreous humor values were well correlated to the ones measured in blood (r2 = 0.658). Our results showed that NT-proBNP can corroborate the pathological findings in cases of natural death related to heart failure, thus, keeping its diagnostic properties passing from the ante mortem to the post mortem setting. Therefore, biologically inactive polypeptides like NT-proBNP seem to be stable enough to be used in forensic medicine as markers of cardiac failure, taking into account the sensitivity and specificity of the test.Electronic supplementary materialThe online version of this article (doi:10.1007/s00414-011-0581-6) contains supplementary material, which is available to authorized users.

show abstract

Neurohormonal activation and diagnostic value of cardiac peptides in patients with suspected mild heart failure

Cited by 9 publications

References 45 publications

Guidelines for the management of adult lower respiratory tract infections - Full version

Guidelines for the management of adult lower respiratory tract infections - Full version

Outpatient Evaluation for Cardiovascular Diseases Using Natriuretic Peptide Testing

Sensitivity and specificity of NT-proBNP to detect heart failure at post mortem examination

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