Neurogenomic mechanisms of social plasticity

Cardoso, Sara D.; Teles, Magda; Oliveira, Rui Filipe

doi:10.1242/jeb.106997

Cited by 102 publications

(129 citation statements)

References 103 publications

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“…Within this framework, individual nodes are hypothesized to serve dynamic functional roles depending on their functional “connectivity” or “coupling” with other nodes (Goodson and Kabelik, 2009; McIntosh, 2004; Teles et al, 2015). It is further hypothesized that organizational plasticity of steroid hormone and neuropeptide systems across the SDMN is an important mechanism contributing to diversity in distributed network function and social behavior within and across species (Barrett et al, 2013; Cardoso et al, 2015; Goodson, 2005; Goodson and Kabelik, 2009; Johnson and Young, 2015; Newman, 1999). …”

Section: Introductionmentioning

confidence: 99%

Oxytocin receptors modulate a social salience neural network in male prairie voles

Johnson

Walum

Xiao

et al. 2017

Hormones and Behavior

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Social behavior is regulated by conserved neural networks across vertebrates. Variation in the organization of neuropeptide systems across these networks is thought to contribute to individual and species diversity in network function during social contexts. For example, oxytocin (OT) is an ancient neuropeptide that binds to OT receptors (OTRs) in the brain and modulates social and reproductive behavior across vertebrate species, including humans. Central OTRs exhibit extraordinarily diverse expression patterns that are associated with individual and species differences in social behavior. In voles, OTR density in the nucleus accumbens (NAc)—a region important for social and reward learning—is associated with individual and species variation in social attachment behavior. Here we test whether OTRs in the NAc modulate a social salience network (SSN)—a network of interconnected brain nuclei thought to encode valence and incentive salience of sociosensory cues—during a social context in the socially monogamous male prairie vole. Using a selective OTR antagonist, we test whether activation of OTRs in the NAc during sociosexual interaction and mating modulates expression of the immediate early gene product Fos across nuclei of the SSN. We show that blockade of endogenous OTR signaling in the NAc during sociosexual interaction and mating does not strongly modulate levels of Fos expression in individual nodes of the network, but strongly modulates patterns of correlated Fos expression between the NAc and other SSN nuclei.

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Section: Introductionmentioning

confidence: 99%

Oxytocin receptors modulate a social salience neural network in male prairie voles

Johnson

Walum

Xiao

et al. 2017

Hormones and Behavior

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show abstract

“…In some cases, these mechanisms operate at different levels of biological organization; for example, early-life social experiences may affect brain structure, while subsequent experiences modulate brain biochemistry [34]. In the context of honey bee aggression, genomics studies demonstrate that brain gene expression patterns track socially-induced behavioral variation, not only for stable shifts in aggression, but also for more rapid and transient changes in phenotype that occur on the order of minutes [24, 25, 28].…”

Section: Introductionmentioning

confidence: 99%

Sequential social experiences interact to modulate aggression but not brain gene expression in the honey bee (Apis mellifera)

Rittschof

2017

Front Zool

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BackgroundIn highly structured societies, individuals behave flexibly and cooperatively in order to achieve a particular group-level outcome. However, even in social species, environmental inputs can have long lasting effects on individual behavior, and variable experiences can even result in consistent individual differences and constrained behavioral flexibility. Despite the fact that such constraints on behavior could have implications for behavioral optimization at the social group level, few studies have explored how social experiences accumulate over time, and the mechanistic basis of these effects. In the current study, I evaluate how sequential social experiences affect individual and group level aggressive phenotypes, and individual brain gene expression, in the highly social honey bee (Apis mellifera). To do this, I combine a whole colony chronic predator disturbance treatment with a lab-based manipulation of social group composition.ResultsCompared to the undisturbed control, chronically disturbed individuals show lower aggression levels overall, but also enhanced behavioral flexibility in the second, lab-based social context. Disturbed bees display aggression levels that decline with increasing numbers of more aggressive, undisturbed group members. However, group level aggressive phenotypes are similar regardless of the behavioral tendencies of the individuals that make up the group, suggesting a combination of underlying behavioral tendency and negative social feedback influences the aggressive behaviors displayed, particularly in the case of disturbed individuals. An analysis of brain gene expression showed that aggression related biomarker genes reflect an individual’s disturbance history, but not subsequent social group experience or behavioral outcomes.ConclusionsIn highly social animals with collective behavioral phenotypes, social context may mask underlying variation in individual behavioral tendencies. Moreover, gene expression patterns may reflect behavioral tendency, while behavioral outcomes are further regulated by social cues perceived in real-time.

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“…Differences in resting gene expression between behavioural types are likely to reflect processes that are involved in maintaining rather than generating a particular neurogenomic state (Zayed & Robinson, 2012; Cardoso et al, 2015). For example, genes that are differentially expressed between alternative phenotypes that differ in aggressiveness (e.g., sneakers vs territory holders) likely reflect processes involved in maintaining the molecular machinery associated with morphological and life history differences between the phenotypes, such as reproductive maturation (Aubin-Horth et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Natural variation in brain gene expression profiles of aggressive and nonaggressive individual sticklebacks

Bell

Bukhari

Sanogo

2016

Behav

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Within many species, some individuals are consistently more aggressive than others. We examine whether there are differences in brain gene expression between aggressive versus nonaggressive behavioural types of individuals within a natural population of male three-spined sticklebacks (Gasterosteus aculeatus). We compared gene expression profiles of aggressive male sticklebacks to nonaggressive males in four regions of the brain (brainstem, cerebellum, diencephalon and telencephalon). Relatively few genes were differentially expressed between behavioural types in telencephalon, cerebellum and diencephalon, but hundreds of genes were differentially expressed in brainstem, a brain area involved in detecting threats. Six genes that were differentially expressed in response to a territorial intrusion in a previous study were also differentially expressed between behavioural types in this study, implying primarily non-shared but some shared molecular mechanisms. Our findings offer new insights into the molecular causes and correlates of behavioural plasticity and individual variation in behaviour.

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Neurogenomic mechanisms of social plasticity

Cited by 102 publications

References 103 publications

Oxytocin receptors modulate a social salience neural network in male prairie voles

Oxytocin receptors modulate a social salience neural network in male prairie voles

Sequential social experiences interact to modulate aggression but not brain gene expression in the honey bee (Apis mellifera)

Natural variation in brain gene expression profiles of aggressive and nonaggressive individual sticklebacks

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