Neurogenic Tumors of the Nasal Fossa

McCormack, Lawrence J.

doi:10.1001/jama.1955.02950210014004

Cited by 87 publications

(22 citation statements)

References 2 publications

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“…Berger and Luc first described ENB in France in 1924 [17, 18]. Since 1924, close to 1,000 cases of ENB have been documented in world literature using various names: esthesioneuroepithelioma, esthesioneurocytoma, esthesioneuroblastoma, olfactory esthesioneuroma, intranasal neuroblastoma, and neural olfactory tumor [17].…”

Section: Discussionmentioning

confidence: 99%

Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup

Shirzadi

Drazin

Strickland

et al. 2013

Case Reports in Surgery

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Esthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium. Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, or leptomeninges. We report a case of ENB with multiple drop metastases to the cervical and thoracic spine, and review the patient's disease, medical history, and multiple interventions during a span of 15 years following the initial cranial resection. Despite aggressive multiple surgical resections, radiation, and chemotherapy, the tumor had significant progression and recurrence. The literature is reviewed, followed by a discussion of the natural progression of the disease and various reported interventions. Although a combination of surgery with chemotherapy and radiation therapy has been recommended, no definitive management has been established for ENB. Further research is needed to determine decisive treatment for metastatic ENB to the spine.

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Section: Discussionmentioning

confidence: 99%

Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup

Shirzadi

Drazin

Strickland

et al. 2013

Case Reports in Surgery

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“…Esthesioneuroblastoma is a rare nasal malignancy that accounts for 3% of all intranasal tumors [1]. A review of the world literature revealed up to 1000 published cases and suggested that the true incidence may be underestimated [2].…”

Section: Introductionmentioning

confidence: 99%

Low-Grade Esthesioneuroblastoma Presenting as SIADH: A Review of Atypical Manifestations

Senchak

Freeman

Ruhl

et al. 2012

Case Reports in Otolaryngology

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Esthesioneuroblastoma (ENB) is a neuroendocrine tumor that typically manifests as advanced stage malignancy in the superior nasal cavity. The hallmark symptoms include nasal obstruction and epistaxis, which result from local tissue invasion. Atypical clinical features can also arise and must be considered when diagnosing and treating ENB. These can include origin in an ectopic location, unusual presenting symptoms, and associated paraneoplastic syndromes. The case described here reports a nasal cavity ENB with atypical clinical features that occurred in a young female. Her tumor was low grade, appeared to arise primarily from the middle nasal cavity, and presented as syndrome of inappropriate antidiuretic hormone (SIADH). She also became pregnant shortly after diagnosis, which had implications on her surgical management. We review the atypical features that uncommonly occur with ENB and the clinical considerations that arise from these unusual characteristics.

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“…4 The sex distribution is roughly equal, 1,5 and it is generally a disease of white individuals. 6 No etiologic basis has been determined.…”

mentioning

confidence: 99%

Olfactory neuroblastoma: The 22-year experience at one comprehensive cancer center

et al. 2005

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Neurogenic Tumors of the Nasal Fossa

Cited by 87 publications

References 2 publications

Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup

Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup

Low-Grade Esthesioneuroblastoma Presenting as SIADH: A Review of Atypical Manifestations

Olfactory neuroblastoma: The 22-year experience at one comprehensive cancer center

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