Neurogenic Sarcoma

Quick, Douglas; Cutler, Max

doi:10.1097/00000658-192712000-00002

Cited by 46 publications

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“…3). These tumours were described as " transitional-cell carcinomas " by Quick and Cutler (1927) (Fig. 4).…”

Section: Histologymentioning

confidence: 99%

Lymphoepitheliomas of the cervical lymph nodes.

Loke¹

1965

Br J Cancer

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IN Malaya there is a high incidence of a peculiar type of malignant tumours of cervical lymph nodes termed " lymphoepithelioma '. These tumours may appear in the cervical lymph nodes without any clinical evidence of a primary growth elsewhere and have, therefore, in previous cancer statistics, sometimes been classified either as metastases of indeterminate origin or as primary tumours of lymphoid tissue. Because of their histological resemblance to certain tumours found in the nasopharynx, and because of their actual association with these in many cases, it is now considered that there is sufficient evidence to justify their inclusion in the class of nasopharyngeal cancers. MATERIAL AND METHODThis study is based on the material collected in the Pathology Division of the Institute for Medical Research, Kuala Laumpur, over the 8 year period from 1953 to 1960 inclusive. The material comprised 134 malignant nasopharyngeal cancers and 430 tumours of cervical lymph nodes of the lymphoepithelioma type. These two groups were compared histologically and their clinical histories carefully reviewed in order to find how many could reasonably be correlated. OBSERVATIONS AND RESULTS HistologyAmong the 134 nasopharyngeal tumours, 118 showed the typical appearance of the " lymphoepithelioma " as described by Regaud (1921) and Schmincke (1921). They consisted of strands of cells with large pale-staining vesicular nuclei and poorly delimited cytoplasm embedded in a stroma rich in lymphocytes. The outlines of the individual cells were indistinct and in many places the appearance was that of a syncytium. In the Regaud type, the tumour cells invaded the nasopharyngeal tissue in small groups or columns which were interspersed, here and there, by numerous lymphocytes (Fig. 1). In the Schmincke type, the tumour cells were more dissociated from one another and seemed to mingle with the lymphoid tissue giving the impression of a mixed cell sarcoma rather than a carcinoma (Fig. 2). However, examination of other areas usually revealed tumour cells arranged in definite epithelial columns. Occasionally, the tumour cells were seen to have coalesced into broad solid alveolar masses sharply demarcated from the lymphoid stroma by varying degrees of fibrosis (Fig. 3). These tumours were described as " transitional-cell carcinomas " by Quick and Cutler (1927)

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“…3). These tumours were described as " transitional-cell carcinomas " by Quick and Cutler (1927) (Fig. 4).…”

Section: Histologymentioning

confidence: 99%

Lymphoepitheliomas of the cervical lymph nodes.

Loke¹

1965

Br J Cancer

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“…The commonest tumour of the nasopharynx has been placed in a number of different categories according to the histopathological interpretation made (Cappell 1934 and1938 ;Ewing 1929 ;Gotfredsen 1944 ;Graff 1934 ;Quick and Cutler 1927;Schmincke 1921;Teoh 1957). However, one invariable feature of the tumour is the poor response to treatment.…”

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confidence: 99%

Arterial Infusion Chemotherapy for Carcinoma of the Nasopharynx

Laing

1965

Int J Clinical Practice

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“…The term "Transitional Cell Carcinoma" was first employed by Quick and Cutler (1927) to describe a group of highly radiosensitive buccopharyngeal tumours of uncertain histogenesis which lacked the classical features of epithelioma, but presented transitional epithelial characters. Ewing's writings (1929,1940) have done much to clarify the morphological features of this growth.…”

mentioning

confidence: 99%

“…Regarding transitional cell carcinoma, Quick and Cutler (.1927) state that in the tonsil and base of tongue, the proportion as compared with squamous growths is 1 to 10. Our ratio is approximately 1 to 6.…”

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confidence: 99%

Squamous Cell Carcinoma of the Buccopharyngeal Region

Ea¹

1947

Br J Cancer

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IN recent years many attempts have been made to correlate the histological appearances of new growths with their clinical behaviour and radio-sensitivity. These studies have disclosed the existence of a group of ill-differentiated highly malignant but equally highly radiosensitive buccopharyngeal carcinomata of uncertain histogenesis. While much attention has been paid to their morphology, the literature yields but scant information of value regarding the relative malignancy of these tumours. Varying nomenclature, inadequate follow-up, and an insufficiency of cases, render many of the views expressed little more than conjectures. The purpose of this paper is to elucidate further the natural history of this group. This we have attempted through an analysis of 408 cases of cancer in the neighbourhood of the mouth. The frankly keratinizing members of our series we have taken as a standard with which to compare the behaviour of our remaining histological types.The morphological features of the more differentiated epitheliomata have been so completely evaluated that any further discussion would be superfluous. Duval and Lacassagne (1922) have probably provided the most complete classification of these growths, but made no attempt to correlate structure with potential malignancy. The most widely known study with this end in view is that of Broders (1920), who grouped the squamous cancers into four grades on the basis of cell differentiation. The anaplastic growths of Grade IV merit a brief description. They are characterized by their large, polygonal, clearly demarcated cells, which are distributed in groups of two or three, in sheets, columns, or as a diffuse infiltration. The cytoplasm is eosinophil in reaction, while the sharply cut, round or oval nucleus houses a coarse chromatin network with a prominent nucleolus. Such growths belong to that poorly differentiated group which has aroused such interest during the past two decades, a group which has become a

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Neurogenic Sarcoma

Cited by 46 publications

References 0 publications

Lymphoepitheliomas of the cervical lymph nodes.

Lymphoepitheliomas of the cervical lymph nodes.

Arterial Infusion Chemotherapy for Carcinoma of the Nasopharynx

Squamous Cell Carcinoma of the Buccopharyngeal Region

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