Neurogenic and Neuroendocrine Effects of Goldfish Pheromones

Chung-Davidson, Yu Wen; Rees, Christopher B.; Bryan, Mara B.; Li, Weiming

doi:10.1523/jneurosci.3589-08.2008

Cited by 36 publications

(22 citation statements)

References 71 publications

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“…Real-time quantitative PCR was performed using the TaqMan MGB system (Applied Biosystems) as described previously (49). Synthetic oligos were used as standards.…”

Section: Methodsmentioning

confidence: 99%

Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey

Yeh

Chung-Davidson

Wang

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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Bile salt synthesis is a specialized liver function in vertebrates. Bile salts play diverse roles in digestion and signaling, and their homeostasis is maintained by controlling input (biosynthesis) and intestinal conservation. Patients with biliary atresia (i.e., obliteration of the biliary tree) suffer liver fibrosis and cirrhosis. In contrast, sea lamprey thrives despite developmental biliary atresia. We discovered that the sea lamprey adapts to biliary atresia through a unique mechanism of de novo synthesis and secretion of bile salts in intestine after developmental biliary atresia, in addition to known mechanisms, such as the reduction of bile salt synthesis in liver. During and after developmental biliary atresia, expression of cyp7a1 in intestine increased by more than 100-fold ( P < 0.001), whereas in liver it decreased by the same magnitude ( P < 0.001). Concurrently, bile salt pools changed in similar patterns and magnitudes in these two organs and the composition shifted from C24 bile alcohol sulfates to taurine-conjugated C24 bile acids. In addition, both in vivo and ex vivo experiments showed that aductular sea lamprey secreted taurocholic acid into its intestinal lumen. Our results indicate that the sea lamprey, a jawless vertebrate, may be in an evolutionarily transitional state where bile salt synthesis occurs in both liver and intestine. Understanding the molecular basis of these mechanisms may shed light on the evolution of bile salt synthesis and possible therapy for infant biliary atresia.

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“…Real-time quantitative PCR was performed using the TaqMan MGB system (Applied Biosystems) as described previously (49). Synthetic oligos were used as standards.…”

Section: Methodsmentioning

confidence: 99%

Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey

Yeh

Chung-Davidson

Wang

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

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“…Immunostaining for noradrenaline (NA) and uncoupling protein (UCP) followed methods described previously (Chung-Davidson et al, 2008). Negative controls (deprived of the NA or UCP antibody) were performed simultaneously in every immunostaining experiment.…”

Section: Histology and Immunohistochemistrymentioning

confidence: 99%

“…Real-time quantitative PCR (RT-qPCR) was performed using the TaqMan MGB system (Life Technologies, Carlsbad, CA, USA) as described previously (Chung-Davidson et al, 2008). Briefly, total RNA was extracted using TRIzol Reagent (Invitrogen, Carlsbad, CA, USA), treated with the TURBO DNA-free kit (Applied Biosystems, Foster City, CA, USA) and diluted to 100ngμl …”

Section: Real-time Quantitative Pcrmentioning

confidence: 99%

A thermogenic secondary sexual character in male sea lamprey

Chung-Davidson

Priess

Yeh

et al. 2013

Journal of Experimental Biology

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SUMMARYSecondary sexual characters in animals are exaggerated ornaments or weapons for intrasexual competition. Unexpectedly, we found that a male secondary sexual character in sea lamprey (Petromyzon marinus) is a thermogenic adipose tissue that instantly increases its heat production during sexual encounters. This secondary sexual character, developed in front of the anterior dorsal fin of mature males, is a swollen dorsal ridge known as the 'rope' tissue. It contains nerve bundles, multivacuolar adipocytes and interstitial cells packed with small lipid droplets and mitochondria with dense and highly organized cristae. The fatty acid composition of the rope tissue is rich in unsaturated fatty acids. The cytochrome c oxidase activity is high but the ATP concentration is very low in the mitochondria of the rope tissue compared with those of the gill and muscle tissues. The rope tissue temperature immediately rose up to 0.3°C when the male encountered a conspecific. Mature males generated more heat in the rope and muscle tissues when presented with a mature female than when presented with a male (paired t-test, P<0.05). On average, the rope generated 0.027±0.013Wcm-3 more heat than the muscle in 10min. Transcriptome analyses revealed that genes involved in fat cell differentiation are upregulated whereas those involved in oxidative-phosphorylation-coupled ATP synthesis are downregulated in the rope tissue compared with the gill and muscle tissues. Sexually mature male sea lamprey possess the only known thermogenic secondary sexual character that shows differential heat generation toward individual conspecifics. Supplementary material available online at

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“…Therefore, PGF 2 á also plays a dual role as a para hormone and hormone, synchronising male and female sexual behavior in Cyprinus carpio. Davidson et al, 2008 have found that exposure to water borne PGF 2 increased neurogenesis and GnRH concentration in male goldfish brain and modulate brain plasticity associated with behavioral changes during spawning season via the neuroendocrine (GnRH) and motor components of the pheromone-reproductive system. This finding confirms the above view in C. carpio in relation with increased number of gonadotrops, olfactory secretion.…”

Section: Discussionmentioning

confidence: 99%

“…In fish, exogenous prostaglandins also show stimulatory effect on the induction of ovulation. F prostaglandins also function as a hormone that stimulates female sexual behavior (Sorensen et al, 1988;Davidson et al, 2008). It is now cleared that this compound is also functioning as potent olfactory stimulants with pheromonal activity in human (Karl et al, 2005) and for many species of fish (Sorensen and Goetz, 1993).…”

Section: Introductionmentioning

confidence: 99%

Effect of prostaglandin on reproduction in relation to pituitary gonadal axis in the fish, Cyprinus carpio (L.)

Dongre¹,

Dabhade²,

Khurad

2012

JANS

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Post-graduate Department of Zoology, RTM Nagpur University, Nagpur -4400 33 (Maharashtra), INDIA *Corresponding author. E-mail: veena_dongre@yahoo.com Received:July 20, 2011; Revised received: March 12, 2012; Accepted: August 14, 2012 Abstract: Prostaglandins are a class of fatty acids which are "traditionally" associated with a variety of autocrine and paracrine functions in the vertebrate body. In many fishes, however, F prostaglandins also function as a hormone that stimulates sexual behavior. In the present study, F prostaglandin was used to assess the efficacy on reproductive behavior and spawning in relation to pituitary gonadal axis in the fish, Cyprinus carpio by administering different doses. Early maturity was observed in fish leading to courtship and spawning. The histological study of olfactory lobe, pituitary gland and gonads showed that the prostaglandin is also functioning as potent olfactory stimulants with sex pheromonal activity of the fish. F prostaglandin was metabolized and released into the water where it functions as a sex pheromone, stimulating male and female sexual behavior resulting into spawning. It was concluded that F prostaglandin acts as an inducer for successful breeding in the fish, C. carpio.

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Neurogenic and Neuroendocrine Effects of Goldfish Pheromones

Abstract: Goldfish (Carassius

Cited by 36 publications

References 71 publications

Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey

Intestinal synthesis and secretion of bile salts as an adaptation to developmental biliary atresia in the sea lamprey

A thermogenic secondary sexual character in male sea lamprey

Effect of prostaglandin on reproduction in relation to pituitary gonadal axis in the fish, Cyprinus carpio (L.)

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