Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism

Bon, Michelle A.M.; Steur, Ernst N.H. Jansen; Vos, Rob A. I. de; Vermes, I.

doi:10.1016/s0304-3940(99)00278-5

Cited by 37 publications

(17 citation statements)

References 12 publications

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“…The overall allele frequency is expected to be the same in patients and controls, but within patients, one would expect a gradient where the allele frequency is the highest among patients with earlier onsets and decreases with increasing onset ages. Numerous studies have examined APOE allele frequencies in PD patients and controls and have not detected a signi®cantly increased e4 frequency [Arai et al, 1994;Marder et al, 1994;Rubinsztein et al, 1994;Ibarreta et al, 1995;Koller et al, 1995;Lucotte et al, 1995;Poduslo et al, 1995;Helisalmi et al, 1996;Whitehead et al, 1996;Bon et al, 1999;Kruger et al, 1999]. Our results are in agreement with these studies as e4 allele frequency was not increased in our study and was similar to the general population.…”

Section: Discussionsupporting

confidence: 92%

“…Although the results have not been consistent, the majority of the studies did not detect a signi®cant difference in APOE allele frequencies between PD patients and control subjects [Arai et al, 1994;Marder et al, 1994;Rubinsztein et al, 1994;Ibarreta et al, 1995;Koller et al, 1995;Lucotte et al, 1995;Poduslo et al, 1995;Helisalmi et al, 1996;Whitehead et al, 1996;Bon et al, 1999;Kruger et al, 1999].…”

Section: Introductionmentioning

confidence: 96%

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Age at onset of Parkinson disease and apolipoprotein E genotypes

et al. 2001

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Several lines of evidence suggest that the variable age at onset of Parkinson disease (PD) is likely influenced by genes. The apolipoprotein E (APOE) gene is associated with onset of Alzheimer disease, and possibly other neurodegenerative disorders. APOE has been investigated in relation to onset of PD, but results have been inconsistent. The aim of the present study was to determine if APOE genotypes are associated with onset age of PD, using a patient population large enough to assure sufficient power. We studied 521 unrelated Caucasian patients with idiopathic PD from movement disorder clinics in Oregon and Washington. Genotyping and statistical analyses were carried out using standard methods. Age at onset of PD was significantly earlier in patients with the varepsilon3varepsilon4/varepsilon4varepsilon4 genotype than in patients with the varepsilon3varepsilon3 genotype (56.1 +/- 10.9 vs. 59.6 +/- 11.0, P = 0.003). The significantly earlier onset of PD was not influenced by the possible effects of recruitment site, family history and gender. The effect of the varepsilon2varepsilon3 genotype on onset of PD differed between the two recruitment sites. There was a trend for earlier onset of PD in varepsilon2varepsilon3 patients than in varepsilon3varepsilon3 patients only in the Oregon sample. In conclusion, APOE is associated with age at onset of PD.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 96%

Age at onset of Parkinson disease and apolipoprotein E genotypes

et al. 2001

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“…The risk factors were independently associated with an increased risk of sporadic PD. Interactions of APOE-ε4 with other loci have also been suggested by the observation that the APOE-ε4 genotype, and gene polymorphisms of CYP2D6 and SNCA, are significantly associated with PD (Bon et al 1999).…”

Section: Apolipoprotein E (Apoe)mentioning

confidence: 94%

Genetics of Parkinsonism: a review

VAUGHAN¹,

DAVIS²,

WOOD³

2001

Annals of Human Genetics

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Idiopathic Parkinson's disease (IPD), a progressive neurodegenerative disorder, is a common cause of disability. No current therapies modify disease progression. The pathological hallmarks are the presence of Lewy bodies and massive loss of dopaminergic neurons in the pars compacta of the substantia nigra. Two genes (SNCA and parkin) as well as two gene loci have now been implicated in the pathogenesis of familial PD. These represent significant progress in our understanding of the disease, considering the rarity of large families, low heritability in the general population and genetic heterogeneity. Mutations in a further gene, UCHL1, have been described in familial PD although the evidence for its role in PD is less clear. Knowledge of the genes described in PD to date should help to define molecular mechanisms of neurodegeneration in PD, as well as in other diseases where defects in protein handling may be a common feature. Nigral degeneration with Lewy body formation and the resulting clinical picture of PD may represent a final common pathway of a multifactorial disease process in which both environmental and genetic factors have a role. This review discusses the major advances in the field to date and illustrates how the existence of genetic factors has now become firmly established.

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“…A small population of PD cases is caused by genetic abnormalities, involving alpha-synuclein (Polymeropoulos et al, 1997;Papadimitrior et al, 1999and Kruger et al,1998, Dauer et al, 2002, ubiquitin (Leroy et al, 1998) and apolipoprotein E (APOE), (Kruger et al, 1999). Changes in chromosome 2p13 (Gasser et al, 1998), cyp2D6 (Kruger et al, 1999;Christensen et al, 1998;Kosel et al, 1996;Bon et al, 1999, Sabbagh et al, 1999 as well as mitochondria tRNA (A4336G) (Epensperger et al, 1997) have also been reported. The mutation of the parkin gene is closely associated with juvenile PD (Kitada et al, 1998), which has about eight variants (Lansbury and Brice, 2002).…”

Section: Major Symptoms and The Proposed Causes For Parkinson's Diseasementioning

confidence: 99%

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

Charlton¹

2013

Basal Ganglia - An Integrative View

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Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism

Cited by 37 publications

References 12 publications

Age at onset of Parkinson disease and apolipoprotein E genotypes

Age at onset of Parkinson disease and apolipoprotein E genotypes

Genetics of Parkinsonism: a review

Fetal and Environmental Basis for the Cause of Parkinson’s Disease

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