Neurogenesis of the hamster suprachiasmatic nucleus

Davis, Fred C.; Boada, Richard; LeDeaux, John R.

doi:10.1016/0006-8993(90)90077-o

Cited by 33 publications

(33 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Accordingly, SCN cytogenesis occurred over three days, between E12 and E15, and was complete 5 days prior to birth. This observation parallels that seen in both rats [3] and hamsters [7,4]. In rats, SCN cell production occurs over 3 days (E14 to E17) and is complete 5 days prior to birth.…”

Section: Discussionsupporting

confidence: 85%

“…Observations in those reports are, however, consistent with such a program. In hamsters, a ventrolateral-to-dorsomedial gradient of cell production was described, with the addition of late-produced cells on the lateral margin of the nucleus [7]. Thus, late-produced cells actually included both a dorsomedial cap and a lateral margin, similar to a shell as described here.…”

Section: Discussionmentioning

confidence: 53%

“…Similar to the formation of rat and hamster SCN, as well as of hypothalamic nuclei in general [2,7], the SCN shows heterochronic waves of cytogenesis. In the present study, two gradients of cytogenesis were observed: a ventrolateral-to-dorsomedial gradient, most evident in middle sections, and, to a lesser extent, a caudal-to-rostral gradient.…”

Section: Discussionmentioning

confidence: 59%

“…SCN neurogenesis has been described for several mammals, in particular rats [3] and hamsters [4,7]. These studies described the ages when SCN cells are "born" (undergo their final mitotic division) and the pattern in which different regions of the SCN are produced.…”

Section: Introductionmentioning

confidence: 99%

“…Altman and Bayer [2] also followed the migration of newly produced cells and traced their origin to the germinal epithelium of the ventral third ventricle. Hamster SCN neurogenesis is similar, although studies in hamsters used greater spatial and temporal resolution [7] and looked at the production of identified cell types [4]. Considering the growing importance of mice in many areas of physiology, including circadian rhythms, it is surprising that a detailed analysis of SCN neurogenesis has not been reported in this species.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Development of the mouse suprachiasmatic nucleus: Determination of time of cell origin and spatial arrangements within the nucleus

Kabrita

Davis

2008

Brain Research

Self Cite

View full text Add to dashboard Cite

The suprachiasmatic nucleus (SCN) in mammals functions as the principal circadian pacemaker synchronizing diverse physiological and behavioral processes to environmental stimuli. It consists of heterogeneous populations of cells with unique spatial organization that can vary among species, but are commonly discussed within a framework of two principal regions, the ventrolateral or dorsomedial halves of the nucleus or in other instances the core and shell. In both hamsters and rats, cells of different SCN regions have been shown to have different developmental histories. Using bromodeoxyuridine as a marker of cell division, the present study investigated the time of SCN cell origin in mice (C57BL/6) and their settling patterns within the nucleus. Results show that SCN cytogenesis occurs between embryonic days 12 and 15 and is complete 5 days prior to birth. Cells born on embryonic day 12 are mainly confined to a ventrolateral region of the mid-SCN, whereas cells produced later on embryonic days 13.5 and 14.5 form a cap around the cells produced first and extend into the posterior and anterior ends of the nucleus. These results suggest an ordered spatiotemporal program of SCN cytogenesis whereby a mid-SCN core is born first followed by a surrounding shell of later-born cells. Variation in cytogenesis could affect the relative sizes of different SCN regions and, thereby, affect its function. The relative contributions of a highly ordered program of cytogenesis and intercellular interactions after post-mitotic cells leave the germinal epithelium remain to be determined.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Development of the mouse suprachiasmatic nucleus: Determination of time of cell origin and spatial arrangements within the nucleus

Kabrita

Davis

2008

Brain Research

Self Cite

View full text Add to dashboard Cite

show abstract

The role ofClock in the developmental expression of neuropeptides in the suprachiasmatic nucleus

et al. 2000

View full text Add to dashboard Cite

The suprachiasmatic nucleus (SCN) is the dominant circadian pacemaker in mammals. To understand better the ontogeny of mouse SCN and the role of the pacemaker in peptide expression, the authors examined the distribution of cells that were immunoreactive for vasopressin (AVP) or vasoactive intestinal polypeptide (VIP) in wild type and Clock mutant mice at two developmental stages. Clock homozygous mice failed to show the dramatic increase in the number of VIP-immunoreactive (VIP-ir) neurons from postnatal day 6 (P6) to P30 that was found in the SCN of wild type mice. The number of AVP-ir neurons was relatively constant in the postnatal SCN but was significantly reduced in Clock/Clock mice. The effects of the Clock mutation varied with position in the SCN for both peptides. Densitometry of immunolabeled brains indicated that the Clock mutation reduced AVP expression specifically in the SCN and not in other brain areas. The SCN did not significantly change shape or size with age or Clock genotype. Taken together, these results indicate that the neonatal mouse SCN has its full complement of cells, some of which are not yet mature in their neuropeptide content. Furthermore, the observation that the Clock mutation appears to act on a subset of AVP and VIP cells suggests heterogeneity within these cell classes in the SCN.

show abstract

Development of Mammalian Circadian Rhythms

Davis

Reppert

2001

Handbook of Behavioral Neurobiology

View full text Add to dashboard Cite

Neurogenesis of the hamster suprachiasmatic nucleus

Cited by 33 publications

References 23 publications

Development of the mouse suprachiasmatic nucleus: Determination of time of cell origin and spatial arrangements within the nucleus

Development of the mouse suprachiasmatic nucleus: Determination of time of cell origin and spatial arrangements within the nucleus

The role ofClock in the developmental expression of neuropeptides in the suprachiasmatic nucleus

Development of Mammalian Circadian Rhythms

Contact Info

Product

Resources

About