2000
DOI: 10.1038/35036235
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Neurogenesis in the adult brain: death of a dogma

Abstract: For over 100 years a central assumption in the field of neuroscience has been that new neurons are not added to the adult mammalian brain. This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse. The acceptance of adult neurogenesis may be part of a contemporary paradigm shift in our view of the plasticity and stability of the adult brain.

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Cited by 713 publications
(401 citation statements)
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References 93 publications
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“…This includes, for example, research on behavioral training that assists older adults in developing compensatory cognitive strategies (e.g. the use of mnemonics, external memory cues, and other environmental and contextual support) 58 that capitalize on using the cortical plasticity that the aging brain seems still to possess 59 .…”
Section: Opinionmentioning
confidence: 99%
“…This includes, for example, research on behavioral training that assists older adults in developing compensatory cognitive strategies (e.g. the use of mnemonics, external memory cues, and other environmental and contextual support) 58 that capitalize on using the cortical plasticity that the aging brain seems still to possess 59 .…”
Section: Opinionmentioning
confidence: 99%
“…It generally maintained its grip until the 1990s. By then, emerging studies had begun to promote a markedly different view of the brain's inherent plasticity (Gross, 2000). They demonstrated the presence of neuronal precursors in the adult brain and the occurrence of neurogenesis-the production of new nerve cells.…”
Section: Neurogenesis In the Adult Brainmentioning
confidence: 99%
“…Neurogenesis has been documented in adult brain of a number of different animals, including bird, rodent, monkey and human (see Gould et al 1999;Gage 2000;Gross 2000). In adult mammalian brain, significant rates of adult neurogenesis are restricted to two brain regions, the olfactory bulb and the hippocampus.…”
Section: Neurogenesis In Adult Brainmentioning
confidence: 99%