Neurogenesis in Adult Subventricular Zone

Abstract

Much excitement has been generated by the identification of adult brain regions harboring neural stem cells and their continual generation of new neurons throughout life. This is an important departure from traditional views of the germinal potential of the postnatal brain. However, a more profound paradigm shift may be emerging. Studies of adult neurogenesis in This work was supported by National Institutes of Health Grants NS28478 and HD32116, by the Sandler Family supporting Foundation, and Fundació la Caixa. We thank Anthony Tramontin and Nader Sanai for their comments on this manuscript.

Neuronal stem cells in the central nervous system and in human diseases

“…Some of the cases are thought to have potentially originated from the SVZ in the brain, where neural stem cells and neural progenitor cells are abundant (Sutton et al, 1992;Tohyama et al, 1992;Alvarez-Buylla and Garcia-Verdugo, 2002). In animal models, the regions of the brain with proliferating cells, such as stem cell or progenitor cell populations, are more sensitive to oncogenic inducers than the areas with inactive proliferating cells (Hopewell, 1975;Vick et al, 1977).…”

Cellular Therapy and Induced Neuronal Replacement for Huntington's Disease

“…In mammals, neural stem cells of the subventricular zone (SVZ) continually generate transit-amplifying glial and neuronal daughters, at least some of which give rise to new neurons [67][68][69][70]; the latter are typically recruited anteriorly to the olfactory bulb as GABAergic interneurons of several phenotypes [68,[71][72][73][74][75]. Olfactory neuronal recruitment is rapid; in mice, it takes approximately 15 days for neuronally restricted progenitor cells of the SVZ to migrate through the rostral migratory stream to the olfactory bulb, traversing a distance of 3 to 5 mm, wherein they differentiate into olfactory interneurons [67,76,77] (for more detail see Whitman and Greer [78] and Abrous et al [79]). In addition, some neural stem cells migrate posteriorly in development to form a separate germinal neuroepithelium, the subgranular zone of the hippocampal dentate gyrus [80][81][82][83].…”

Expression of the transcription factor Olig2 in proliferating cells in the adult zebrafish telencephalon

“…In the adult mammalian brain, two regions display neurogenic potential: The subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus located in the hippocampus harbour neural stem cells with astrocytic features generating predominantly neurons (Doetsch et al, 1999;Gage, 2000;Seri et al, 2001;Alvarez-Buylla and Garcia-Verdugo, 2002;Kempermann, 2002;Garcia et al, 2004). In contrast, more than 16 discrete sites produce new neurons in the brain of an adult zebrafish Grandel et al, 2006).…”