Neurofunctional correlates of vulnerability to psychosis: A systematic review and meta-analysis

Fusar‐Poli, Paolo; Pérez, Jorge; Broome, Matthew R.; Borgwardt, Stefan; Placentino, Anna; Caverzasi, Eduardo; Cortesi, Mariachiara; Veggiotti, Pierangelo; Politi, Pierluigi; Barale, Francesco; McGuire, Philip

doi:10.1016/j.neubiorev.2006.11.006

Cited by 270 publications

(202 citation statements)

References 106 publications

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…This result is in keeping with a large literature suggesting that family members of individuals with schizophrenia have an increased risk of developing the disorder (Gottesman, 1991), electrophysiological deficits (Clementz et al, 1998;Cadenhead et al, 2000), abnormal brain activation (Callicott et al, 2003;Fusar-Poli et al, 2007), and a variety of structural brain abnormalities (Boos et al, 2007). Such measures represent potential "endophenotypes" that may help clarify the relationship between genetic variation and the clinical symptoms of schizophrenia (Gottesman and Gould, 2003;Braff et al, 2007).…”

Section: Discussionsupporting

confidence: 84%

Thalamic Shape Abnormalities in Individuals with Schizophrenia and Their Nonpsychotic Siblings

Harms

Wang²,

Mamah³

et al. 2007

J. Neurosci.

View full text Add to dashboard Cite

Deficits in the volume of the thalamus have been observed in both individuals with schizophrenia and their nonpsychotic relatives. However, no studies to date have examined the underlying pattern of thalamic shape change in relatives of individuals with schizophrenia. This study examined the volume and shape of the thalamus in schizophrenia subjects, their siblings, and healthy control individuals. T1-weighted magnetic resonance scans were collected in a group of young subjects with schizophrenia (mean age, 23 years) and their nonpsychotic siblings (n ϭ 25 pairs), and control subjects and their siblings (n ϭ 40 pairs). Thalamic surfaces were generated using high-dimensional brain mapping. A canonical weighting function was derived from the contrast between schizophrenia and control subjects and then used to generate a canonical shape score for all subjects. Maps of the estimated surface displacement between groups were also created to visualize the thalamic shape differences between groups. The thalamic canonical scores of the siblings of the schizophrenia probands were intermediate between the probands and healthy control subjects. These siblings also displayed an intermediate degree of the inward surface deformation of the anterior and posterior thalamus that was present between schizophrenia probands and controls. There was no main effect of group status on thalamic volume and no significant correlations of the structural measures with measures of psychopathology or cognitive function. Our results indicate that thalamic shape abnormalities are present in relatively young individuals with schizophrenia and their siblings. Inward deformation of the anterior and posterior regions of the thalamus represents a potential neuroanatomical endophenotype of schizophrenia.

show abstract

Section: Discussionsupporting

confidence: 84%

Thalamic Shape Abnormalities in Individuals with Schizophrenia and Their Nonpsychotic Siblings

Harms

Wang²,

Mamah³

et al. 2007

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…19 Such abnormalities are consistent with structural and functional imaging studies in patients at risk for psychosis. [44][45][46] In support of these findings, previous diffusion tensor imaging (DTI) studies in patients with schizophrenia have confirmed reduced anisotropy in the frontal cortex, 47-50 the anterior cingulum 51,52 and the tempor al lobe. 20,53 The ARMS group also showed a reduced P300 amplitude compared with controls, in line with our previous results in a larger sample 14 and with other studies in patients at risk for psychosis.…”

Section: Discussionsupporting

confidence: 52%

“…There is also consistent neuro imaging evidence indicating that the prefrontal cortex is already altered in the ARMS group. 44 Finally, we have attempted to identify the core abnormalities underlying transition to psychosis. 65 Thus, we have compared the ARMS-T and the ARMS-NT subgroups.…”

Section: Discussionmentioning

confidence: 99%

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

Fusar‐Poli

Crossley

Woolley

et al. 2011

jpn

Self Cite

View full text Add to dashboard Cite

“…Investigation of subjects at the onset of the disease avoids potential confounders such as antipsychotic treatment [62][63][64][65]. A clinical high-risk status for psychosis (at risk mental state, ARMS) is associated with a set of neurofunctional abnormalities that are qualitatively similar to those observed in patients with the disorder [66]. As these findings are not attributable to chronic psychotic symptoms [67] and antipsychotic treatment, they may represent markers of increased vulnerability to psychotic disorders.…”

Section: Effects Of Antipsychotic Medication On Structural Neuroimagimentioning

confidence: 99%

The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? – A Systematic Review

Smieskova

Fusar‐Poli²,

Allen³

et al. 2009

CPD

185

131

View full text Add to dashboard Cite

Abstract:Despite a large number of neuroimaging studies in schizophrenia reporting subtle brain abnormalities, we do not know to what extent such abnormalities reflect the effects of antipsychotic treatment on brain structure. We therefore systematically reviewed cross-sectional and follow-up structural brain imaging studies of patients with schizophrenia treated with antipsychotics. 30 magnetic resonance imaging (MRI) studies were identified, 24 of them being longitudinal and six cross-sectional structural imaging studies. In patients with schizophrenia treated with antipsychotics, reduced gray matter volume was described, particularly in the frontal and temporal lobes. Structural neuroimaging studies indicate that treatment with typical as well as atypical antipsychotics may affect regional gray matter (GM) volume. In particular, typical antipsychotics led to increased gray matter volume of the basal ganglia, while atypical antipsychotics reversed this effect after switching. Atypical antipsychotics, however, seem to have no effect on basal ganglia structure.

show abstract

Neurofunctional correlates of vulnerability to psychosis: A systematic review and meta-analysis

Cited by 270 publications

References 106 publications

Thalamic Shape Abnormalities in Individuals with Schizophrenia and Their Nonpsychotic Siblings

Thalamic Shape Abnormalities in Individuals with Schizophrenia and Their Nonpsychotic Siblings

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

The Effects of Antipsychotics on the Brain: What Have We Learnt from Structural Imaging of Schizophrenia? – A Systematic Review

Contact Info

Product

Resources

About