Neurofilament Light Chains in Systemic Amyloidosis: A Systematic Review
Milou Berends,
Hans L. A. Nienhuis,
David Adams
et al.
Abstract:Peripheral and autonomic neuropathy are common disease manifestations in systemic amyloidosis. The neurofilament light chain (NfL), a neuron-specific biomarker, is released into the blood and cerebrospinal fluid after neuronal damage. There is a need for an early and sensitive blood biomarker for polyneuropathy, and this systematic review provides an overview on the value of NfL in the early detection of neuropathy, central nervous system involvement, the monitoring of neuropathy progression, and treatment eff… Show more
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