Neurofilament and glial fibrillary acid protein-related immunoreactivity in rodent enteric nervous system

Björklund, Håkan; Dahl, D.; Seiger, Åke

doi:10.1016/0306-4522(84)90153-2

Cited by 79 publications

(39 citation statements)

References 35 publications

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“…At this site, GFAP ϩ processes are associated with intestinal blood vessels both within the submucosa (18) and mesentery (29). Therefore, enteric glial cells likely control the integrity and permeability of the submucosal blood vessels.…”

Section: Discussionmentioning

confidence: 99%

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Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?

Cornet

Savidge

Cabarrocas

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

288

276

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Early pathological manifestations of Crohn's disease (CD) include vascular disruption, T cell infiltration of nerve plexi, neuronal degeneration, and induction of T helper 1 cytokine responses. This study demonstrates that disruption of the enteric glial cell network in CD patients represents another early pathological feature that may be modeled after CD8 ؉ T cell-mediated autoimmune targeting of enteric glia in double transgenic mice. Mice expressing a viral neoself antigen in astrocytes and enteric glia were crossed with specific T cell receptor transgenic mice, resulting in apoptotic depletion of enteric glia to levels comparable in CD patients. Intestinal and mesenteric T cell infiltration, vasculitis, T helper 1 cytokine production, and fulminant bowel inflammation were characteristic hallmarks of disease progression. Immune-mediated damage to enteric glia therefore may participate in the initiation and͞or the progression of human inflammatory bowel disease.

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Section: Discussionmentioning

confidence: 99%

“…These cells envelop enteric neuronal cell bodies and axon bundles (15), as well as intestinal blood vessels (18,29), and extend into the intestinal mucosa (14,20). In addition to shared phenotypic features with astrocytes, they probably perform other common functions (15)(16)(17).…”

Section: Discussionmentioning

confidence: 99%

Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?

Cornet

Savidge

Cabarrocas

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

288

276

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“…Previous studies [8,11,[13][14][15]17] re ported the existence of various immunoreactive nerve fibers in the mucosal plexus. The methods used in this experiment permitted a clear observation of the neuronal network in the mucosal plexus.…”

Section: Discussionmentioning

confidence: 99%

“…The function of G0 has not been fully elucidated, but it was suggested that G0 regulates neuronal calcium channels [4], Im tion in rat ileum. We examined the distribu tion and organization of G0-positive struc tures in the ileum using a whole mount prepa ration [11,12,15,17,18]. G0a antibodies with the use of a whole mount tissue prepara tion provided an excellent method for exam ining the distribution of G0.…”

Section: Introductionmentioning

confidence: 99%

Localization of GTP-Binding Protein G<sub>o</sub> in the Enteric Nervous System in Rat Ileum

Nagahama¹,

Kato²,

Tsutsui³

et al. 1992

Biological Signals

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The localization of a GTP-binding protein G_o was examined immunohistochemically in rat ileum using antibodies against the α-subunit of G_o (G_oα). G_oα-positive fibers clearly demonstrated the topography and structure of the enteric nervous system of the ileum. G_oα was present only in the nervous system and was generally distributed both in synapse-rich and in nonsynaptic areas. The distribution of G_oα in a nonsynaptic area suggests the possibility that G_o may be involved not only in neurotransmission mechanisms but also in other functions.

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“…Neurofilaments contain three major proteins with molecular weights of approximately 68,000, 150,000, and 200,000 daltons [Weber et al, 1983]. Neurofilaments have been demonstrated in the avian, rodent and human ENS [Payette et al, 1984;Bjorklund et al, 1984;Bishop et al, 1985]. Comparative studies indicate that they represent an evolutionarily conserved, three-member protein family .…”

Section: Cytoskeleton Proteinsmentioning

confidence: 99%

Monoclonal Antibodies for Diagnosis and Research in Enteric Nervous System Pathology

Tibboel

Meijers²,

Klück³

et al. 1987

Dev Neurosci

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Monoclonal antibodies (MAb) directed against neuron-specific epitopes are valuable tools in the diagnosis of congenital and acquired enteric nervous system anomalies. MAb raised against cytoskeleton proteins (neurofilaments) revealed a characteristic staining pattern in patients with various motility disorders of the gut. Application of MAb in the study of the development of the enteric nervous system in the chicken embryo provided new insights into the fate of migrating neural crest cells. The relationship between mesenchymal target cells in the gut and proliferating neural crest cells was studied by means of MAb raised against cell surface markers (HNK-1) in combination with characterization of the microenvironment using monoclonal antibodies raised against cell adhesion molecules (N-CAM).

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Neurofilament and glial fibrillary acid protein-related immunoreactivity in rodent enteric nervous system

Cited by 79 publications

References 35 publications

Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?

Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?

Localization of GTP-Binding Protein G<sub>o</sub> in the Enteric Nervous System in Rat Ileum

Monoclonal Antibodies for Diagnosis and Research in Enteric Nervous System Pathology

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