Neurofibromatosis induced hip arthritis. An unusual presentation

Alrumaih, Husam A.; Ilyas, Imran; Kashif, Syed

doi:10.12659/ajcr.889726

Cited by 4 publications

(3 citation statements)

References 9 publications

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“…Only a few described cases had a dislocation hip with or without intra‐articular neurofibromas. 5 , 7 , 8 , 12 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22…”

Section: Discussionmentioning

confidence: 99%

Intra‐articular hip neurofibromas in von Recklinghausen's disease

Ferjani

Moalla

Maatallah

et al. 2021

Clinical Case Reports

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“…Only a few described cases had a dislocation hip with or without intra‐articular neurofibromas. 5 , 7 , 8 , 12 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22…”

Section: Discussionmentioning

confidence: 99%

Intra‐articular hip neurofibromas in von Recklinghausen's disease

Ferjani

Moalla

Maatallah

et al. 2021

Clinical Case Reports

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“…It can be differentiated from NF-1 from its affinity for central nervous tissue, hence presenting with characteristic bilateral vestibular acoustic neuromas, ependymomas, and meningiomas. Spinal cord involvement can be seen in the form of intradural tumors and intramedullary masses [ 11 ], but there are no known orthopedic manifestations of NF-2 [ 8 , 14 ].…”

Section: Tibial Involvementmentioning

confidence: 99%

Tibial Dysplasia in Neurofibromatosis-1: A Rare Case Report and Review of Literature

Ambade,

Malik

2024

jocr

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Background: Neurofibromatosis-1 (NF-1) is a neurocutaneous disorder, primarily affecting the skin and nervous system. Concomitant multi-system involvement is also seen. Orthopedic manifestations of NF-1 are one area that is understudied and underreported, highlighting the importance of this case report. Case Report: A 16-year-old male presented with painless swelling on the posteromedial aspect of the lower right tibia, which was confirmed to be a dysplastic mass on biopsy. Physical examination also revealed cafe au lait macules and axillary freckling, leading to a diagnosis of NF-1. Discussion: Bony lesions in NF-1 patients mainly include the spine and tibia. Congenital tibial dysplasia is commonly associated with NF-1 and may progress to pseudoarthrosis if early management is not started. Treatment modalities include excision, bracing, and fixation. Conclusion: Further research is required to have a more comprehensive view of NF-1 and orthopedics, to diagnose and manage such bony complications. Keywords: Neurofibromatosis-1, orthopedic manifestations, tibial dysplasia.

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“… 3 Arthritis has also been diagnosed in patients with NF, although all but one report to date have focused on pathology at the hip joint. 4 There are no reports detailing outcomes of knee arthroplasty and open reduction internal fixation procedures, in patients with NF. As such, other than amputation, no comprehensive treatment plans have been established to guide the management of orthopedic manifestations of NF at the knee joint.…”

Section: Introductionmentioning

confidence: 99%

Unicompartmental Knee Arthroplasty for Severe Osteoarthritis and Pseudarthrosis in a Patient with Neurofibromatosis

Balaji

Toga

Kano

et al. 2021

ORR

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We describe the case of a 76-year-old Asian female patient who presented with severe pain and a valgus deformity of the right knee. Her past medical history included neurofibromatosis, which resulted in a severe anterior slope of the right knee, limb shortening, and congenital pseudarthrosis. She was diagnosed with severe anterolateral osteoarthritis and eburnation of the right knee that was treated surgically with a lateral unicompartmental knee arthroplasty (UKA). Bone and cartilage fragments were removed from the joint space and a UKA implant (Zimmer ® ) with dimensions of 29 mm × 50 mm was inserted. Perioperative imaging revealed that the procedure resulted in the correction of the valgus deformity. Pain was reduced and the patient was able to walk for 10 meters with support during the immediate postoperative period. One week post-surgery, the patient sustained an oblique tibial fracture that extended from the medial edge of the implant to the medial slope of the proximal tibia. This complication may have been attributed to large implant size or sagittal overcutting. The fracture was treated surgically with a rotated anterolateral locking plate (A.L.P.S ® ) inserted into the distal tibia. The patient was capable of ambulation at full weight load at two months after the second procedure. It is critical to recognize that there are no standard protocols that can be used to guide the treatment of neurofibromatosis-induced osteoarthritis. The specific preoperative condition of the individual patient plays a large role in determining the appropriate treatment option. In this case, the availability of custom-fitted UKA implants might have improved outlook, we understand that these devices are costly and may not be available at all hospitals. However, we strongly believe that the "gold standard" in these cases is patient-specific treatment that addresses the issues of the highest concern using the resources that are available at that time.

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Neurofibromatosis induced hip arthritis. An unusual presentation

Cited by 4 publications

References 9 publications

Intra‐articular hip neurofibromas in von Recklinghausen's disease

Intra‐articular hip neurofibromas in von Recklinghausen's disease

Tibial Dysplasia in Neurofibromatosis-1: A Rare Case Report and Review of Literature

Unicompartmental Knee Arthroplasty for Severe Osteoarthritis and Pseudarthrosis in a Patient with Neurofibromatosis

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