Neurofibroma with increased uptake of [F-18]-fluoro-2 deoxy-d-glucose interpreted as a metastatic lesion

Hsu, Chih Yang; Lee, Chi-Ming; Wang, Fong Chieh; Fang, Chia‐Lang

doi:10.1007/bf03006677

Cited by 20 publications

(5 citation statements)

References 13 publications

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“…Moreover, the gliosis in the avulsed roots also contributes to higher FDG uptake. This result was supported by previous studies, which demonstrated increased uptake of FDG through PET in the neurofibroma of peripheral nerves [ 34 , 35 ].…”

Section: Discussionsupporting

confidence: 89%

Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT

Ling

Tang

et al. 2015

PLoS ONE

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Brachial plexus root avulsion (BPRA) leads to dramatic motoneuron death and glial reactions in the corresponding spinal segments at the late stage of injury. To protect spinal motoneurons, assessment of the affected spinal segments should be done at an earlier stage of the injury. In this study, we employed 18F-FDG small-animal PET/CT to assess the severity of BPRA-induced cervical spinal cord injuries. Adult Sprague-Dawley rats were randomly treated and divided into three groups: Av+NS (brachial plexus root avulsion (Av) treated with normal saline), Av+GM1 (treated with monosialoganglioside), and control. At time points of 3 day (d), 1 week (w), 2 w, 4 w and 8 w post-injury, 18F-FDG micro-PET/CT scans and neuropathology assessments of the injured spinal roots, as well as the spinal cord, were performed. The outcomes of the different treatments were compared. The results showed that BPRA induced local bleeding and typical Wallerian degeneration of the avulsed roots accompanied by 18F-FDG accumulations at the ipsilateral cervical intervertebral foramen. BPRA-induced astrocyte reactions and overexpression of neuronal nitric oxide synthase in the motoneurons correlated with higher 18F-FDG uptake in the ipsilateral cervical spinal cord during the first 2 w post-injury. The GM1 treatment reduced BPRA-induced astrocyte reactions and inhibited the de novo nNOS expressions in spinal motoneurons. The GM1 treatment also protected spinal motoneurons from avulsion within the first 4 w post-injury. The data from this study suggest that 18F-FDG PET/CT could be used to assess the severity of BPRA-induced primary and secondary injuries in the spinal cord. Furthermore, GM1 is an effective drug for reducing primary and secondary spinal cord injuries following BPRA.

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Section: Discussionsupporting

confidence: 89%

Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT

Ling

Tang

et al. 2015

PLoS ONE

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“…With use of an SUV of 2.5 as a cutoff value, they were able to differentiate between malignant and benign neurogenic tumors (61). However, other investigators have reported an overlap between benign and malignant lesions with respect to FDG uptake (62,63).…”

Section: Discussionmentioning

confidence: 98%

Tumors in the Tracheobronchial Tree: CT and FDG PET Features

Park

Goo²,

Lee³

et al. 2009

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108

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A variety of tumors, including primary malignant tumors, secondary malignant tumors, and benign tumors, can occur in the tracheobronchial tree. Primary malignant tumors commonly originate from the surface epithelium or the salivary glands, whereas most benign tumors arise from the mesenchymal tissue. At computed tomography (CT), primary malignant tumors manifest as a polypoid lesion, a focal sessile lesion, eccentric narrowing of the airway lumen, or circumferential wall thickening. At fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET), most squamous cell carcinomas show high uptake, whereas adenoid cystic carcinoma and mucoepidermoid carcinoma show variable uptake depending on the grade of differentiation. High-grade malignancies tend to show high and homogeneous uptake. Carcinoid tumors commonly show intense enhancement at contrast material-enhanced CT, which can be helpful in making the diagnosis, and usually have lower uptake at FDG PET than would be expected for a malignant tumor. Secondary malignant tumors occur as a result of either hematogenous metastasis or direct invasion by a malignancy from an adjacent structure. Their CT manifestations are similar to those of primary malignant tumors, with uptake at FDG PET depending primarily on the metabolic activity and degree of differentiation of the primary tumor. Among the benign tumors, hamartoma and lipoma can show characteristic CT findings such as "popcorn" calcification or internal fat. However, CT findings in most benign tumors are nonspecific. At FDG PET, benign tumors usually show little or no uptake and can be differentiated from malignant tumors. Knowledge of the characteristic CT and FDG PET findings of tracheobronchial tumors can aid in diagnosis and treatment planning.

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“…The overall risk of cancer in NF1 patients is 2.7 times higher than the general population with the most common neoplasms originating from connective tissue or the central nervous system (CNS); however, there is no greater risk of cancer at other sites [2]. Perhaps, it is not surprising then that we could identify only one other case in the English literature in which PET was used to distinguish metastatic carcinoma from a benign neurofibroma [3]. In this case, a 46-year-old female with a past history of early stage rectal cancer presented with a posterior mediastinal mass.…”

Section: Discussionmentioning

confidence: 92%

18F-FDG-PET imaging of a benign neurofibroma masquerading as metastatic oesophageal carcinoma

et al. 2009

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We present the case of a 65-year-old male with squamous cell carcinoma of the thoracic oesophagus on a background of neurofibromatosis type 1. On computed tomography, he was noted to have a large left-sided superior mediastinal mass. Initially, this mass was thought to be metastatic lymphadenopathy; however, it did not display fluorodeoxyglucose uptake on positron emission tomography. Subsequent biopsy confirmed the mass to be a neurofibroma and the patient commenced definitive chemo-radiation. Positron emission tomography had a major impact on management since the presumed lymph node disease was not included in the radiation field. In addition, positron emission tomography altered prognostic stratification since lymph node involvement is a poor prognostic factor in oesophageal cancer. We could only identify one other case in the English literature in which positron emission tomography was used to distinguish metastatic carcinoma from a neurofibroma, although there are a number of reports that describe the utility of positron emission tomography in differentiating benign neurofibromas from malignant connective tissue tumours.

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Neurofibroma with increased uptake of [F-18]-fluoro-2 deoxy-d-glucose interpreted as a metastatic lesion

Cited by 20 publications

References 13 publications

Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT

Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT

Tumors in the Tracheobronchial Tree: CT and FDG PET Features

18F-FDG-PET imaging of a benign neurofibroma masquerading as metastatic oesophageal carcinoma

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