Neurofibroma in the Colon

Wiesen, Ari; Davidoff, Samuel; Sideridis, Kostas; Greenberg, Ronald; Bank, S; Falkowski, Olga

doi:10.1097/01.mcg.0000190777.42656.19

Cited by 11 publications

(6 citation statements)

References 8 publications

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“…He presented for routine screening colonoscopy that detected two polyps, with subsequent histology revealing a neurofibroma, confirmed by S100 staining. This is the fourth reported case of isolated colonic neurofibroma in a patient without NF1, and only the second one found in an asymptomatic patient undergoing routine colorectal cancer screening[11,12,13]. Unfortunately, this patient was lost to follow-up and no repeat colonoscopies were performed.…”

Section: Discussionmentioning

confidence: 93%

An Isolated Neurofibromal Polyp of the Colon

Hindy

Parvin

Hanna³

et al. 2012

Case Rep Gastroenterol

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Solitary neurofibromal colonic polyps are a rare entity, particularly outside the setting of neurofibromatosis type 1. The clinical significance of such lesions has not yet been established. Though typically benign tumors, neurofibromas have been reported to undergo malignant transformation, with an increased risk of malignancy when associated with neurofibromatosis. In this case report, we present the rare case of a man found to have an isolated colonic neurofibroma without any personal/family history or clinical features of neurofibromatosis. A 59-year-old man with a history of dyslipidemia and degenerative joint disease presented for a routine screening colonoscopy. The colonoscopy revealed no abnormalities except a 3 mm transverse colon polyp and another 4 mm polyp in the descending colon. Biopsy results showed the descending colonic polyp to be a tubular adenoma; however, multiple levels of the 3 mm transverse colon polyp revealed interlacing bundles of spindle cells extending into the lamina propria with comma-shaped nuclei consistent with findings seen in neurofibroma. Isolated colonic neurofibromas are rare and understudied. While they are usually benign, they may undergo malignant transformation, especially when associated with neurofibromatosis. Thus, patients presenting with isolated neurofibromas should be followed for development of neurofibromatosis and malignancies.

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Section: Discussionmentioning

confidence: 93%

An Isolated Neurofibromal Polyp of the Colon

Hindy

Parvin

Hanna³

et al. 2012

Case Rep Gastroenterol

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“…11 Neurofibroma has been described to occur nearly anywhere in the body throughout the peripheral nervous system including within the cutaneous, subcutaneous, and deep tissues of the head, neck, extremities, trunk and abdominal wall, in the spine, mediastinum, liver, mesentery, and retroperitoneum, and any segment of the gastrointestinal tract. 3,[12][13][14][15][16][17][18][19][20] Histologically, neurofibroma is a somewhat demarcated but unencapsulated nodule containing clusters of elongated cells with S-shaped or wavy darkly staining nuclei, admixed with strands of collagen said to appear as shredded carrots, in a background of pale pink mucinous or myxoid stroma dotted with numerous mast cells. 11,21,22 Neurofibroma shows S100positive Schwann cells, lattice-like CD34-positive fibroblasts, factor XIIIa-positive fibroblast-like cells, and neurofilaments.…”

Section: Discussionmentioning

confidence: 99%

Intranodal Neurofibroma: A Case Report and Literature Review

Adams¹,

Huston²,

Lozeau

2022

The American Journal of Dermatopathology

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Purpose:To report a case of neurofibroma involving the lymph nodes and to perform a literature review on this topic.Observations:A 72-year-old woman with a history of neurofibromatosis and biopsy-proven malignant melanoma of the left forearm underwent wide local excision of the malignant lesion along with sentinel axillary lymph node biopsy. Histological examination of axillary nodes revealed diffuse neurofibromatosis within 2 lymph node capsules. A thorough review of the English literature pertaining to intranodal neurofibroma was performed by querying Google Scholar and PubMed. Only 5 cases of intranodal neurofibroma have been described until now.Conclusions and Importance:Neurofibroma involving the lymph nodes is rare and this is the first reported case that is shown to diffusely involve the intracapsular space. Furthermore, intranodal neurofibroma can represent a diagnostic pitfall in the evaluation of sentinel lymph nodes for metastatic melanoma.

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“…It is classically associated with neurofibromatosis type 1 (NF1; von Recklinghausen disease). NF1 is a common neurocutaneous disorder occurring in 1 of 3,000 births, and is caused by a mutation in chromosome 17q11.2 affecting neurofibromin of the RAS GTPase activating protein family, a tumor suppressor gene [1]. Schwann cells were discovered to be the cells of origin for neurofibromas, but understanding the more complicated interplay of multiple cell types in tumorigenesis – specifically of recruited heterogeneous cell types such as mast cells and fibroblasts – has important implications for surgical therapy of these tumors [2].…”

Section: Introductionmentioning

confidence: 99%

“…Gastrointestinal neurofibroma usually develops as diffuse gastrointestinal involvement in NF1 patients. Gastrointestinal involvement has been documented in 25% of patients with NF1, and most of the neurofibromas are located in the stomach and small intestine [1, 5]. …”

Section: Introductionmentioning

confidence: 99%

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Neurofibroma of the Colon: A Diagnostic Mimicker of Gastrointestinal Stromal Tumor

Ahn

Chung

Kim

2016

Case Rep Gastroenterol

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Gastrointestinal neurofibroma usually develops as diffuse gastrointestinal involvement in neurofibromatosis type 1 patients. Only 4 cases of sporadic colonic neurofibroma in a patient without neurofibromatosis type 1 have been reported in the English literature. A 26-year-old female patient underwent colonoscopy, and a 4-cm-sized polypoid mass was identified in the sigmoid colon. Wedge resection of the mass showed a yellowish, hard submucosal tumor. Microscopically, the tumor was composed of wavy spindle cells, fibroblasts, and strands of collagen; the stroma showed scattered myxoid areas. The differential diagnoses included gastrointestinal stromal tumor, schwannoma, and neurofibroma. Immunohistochemistry for c-Kit, DOG (discovered on gastrointestinal stromal tumors)-1, smooth muscle actin, S-100 protein, and CD34 was performed. The tumor cells were diffusely positive for CD34 and S-100 protein, while they were completely negative for c-Kit, DOG-1, and smooth muscle actin. The final diagnosis was neurofibroma. Sporadic colonic neurofibroma is very rare. Given the diffuse positivity for CD34 and its rarity, colonic neurofibroma can be easily misdiagnosed as gastrointestinal stromal tumor. Recognition of this entity would be beneficial for pathologists to avoid misdiagnosis and unnecessary treatment.

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Neurofibroma in the Colon

Cited by 11 publications

References 8 publications

An Isolated Neurofibromal Polyp of the Colon

An Isolated Neurofibromal Polyp of the Colon

Intranodal Neurofibroma: A Case Report and Literature Review

Neurofibroma of the Colon: A Diagnostic Mimicker of Gastrointestinal Stromal Tumor

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